Results 31 to 40 of about 16,962 (222)

Nullity of contracts in the Spanish and the Philippines Civil Code [PDF]

open access: yes, 2016
14 páginas.Trabajo de Curso de Experto Universitario en Derecho Español Impartido en Inglés: Estudio de Conjunto (2014/15). Tutor: D. José Manuel de Torres Perea.
Blanco Curtido, Juan Manuel
core  

The newfound relationship between extrachromosomal DNAs and excised signal circles

open access: yesFEBS Letters, EarlyView.
Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley   +1 more source

Classification of Ordered Type Soliton Metric Lie Algebras by a Computational Approach

open access: yes, 2013
In this study, we classify some soliton nilpotent Lie algebras and possible candidates in dimension 8 and 9 up to isomorphy. We focus on 1 < 2 < ::: < n type of derivations where n is the dimension of the Lie algebras.
Kadioglu, Hulya
core   +2 more sources

An upstream open reading frame regulates expression of the mitochondrial protein Slm35 and mitophagy flux

open access: yesFEBS Letters, EarlyView.
This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva   +5 more
wiley   +1 more source

The geometric Cauchy problem for developable submanifolds

open access: yes, 2019
Given a smooth distribution $\mathscr{D}$ of $m$-dimensional planes along a smooth regular curve $\gamma$ in $\mathbb{R}^{m+n}$, we consider the following problem: To find an $m$-dimensional developable submanifold of $\mathbb{R}^{m+n}$, that is, a ruled
Raffaelli, Matteo
core   +1 more source

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

open access: yesMolecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice   +16 more
wiley   +1 more source

A sharp estimate for the index of relative nullity

open access: yesMatemática Contemporânea, 1993
The paper announces results proofs of which can be found in the author's paper [Math. Ann. 298, No. 1, 187-192 (1994; Zbl 0810.53011)].
openaire   +2 more sources

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

open access: yesMolecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu   +10 more
wiley   +1 more source

The Lagrangian Conley Conjecture

open access: yes, 2010
We prove a Lagrangian analogue of the Conley conjecture: given a 1-periodic Tonelli Lagrangian with global flow on a closed configuration space, the associated Euler-Lagrange system has infinitely many periodic solutions.
Mazzucchelli, Marco
core   +3 more sources

Adaptor protein CIN85 potentiates the motility of osteosarcoma cells via the Akt/mTOR and MMP2‐COL3A1 axis

open access: yesMolecular Oncology, EarlyView.
CIN85 is highly expressed in osteosarcoma, particularly in metastatic lesions. Its overexpression increases cell migration and Matrigel invasion, while silencing CIN85 suppresses these behaviors. Transcriptome analysis shows that CIN85 regulates MMP2, COL3A1, and Akt/mTOR signaling. Targeting these pathways reverses CIN85‐induced motility, highlighting
Iryna Horak   +10 more
wiley   +1 more source

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