Results 41 to 50 of about 3,393,351 (259)

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Near Critical Gas Condensate Relative Permeability of Carbonates [PDF]

, 2008
Typical gas condensate fields contain a gas/liquid system during depletion. Such systems are difficult to model experimentally because they exhibit near-miscible behavior at high pressure and temperature. One way to simplify laboratory experimentation is
Çalışgan, Hüseyin, Akın, Serhat
core   +1 more source

Characterization of therapeutic antibodies targeting lymphatic and vascular resistance factor for the treatment of hypervascularized and highly metastatic cancers

Molecular Oncology, EarlyView.
LVRF (lymphatic and vascular resistance factor) is a VEGFA splice variant upregulated in response to anti‐angiogenic therapy that fosters tumor adaptation through enhanced vascularization, lymphangiogenesis, and metastatic dissemination. Targeting LVRF with fully human neutralizing antibodies disrupts these processes and limits resistant tumor growth ...
Marion David, Arthur Karaulic, Audrey Bennetot, Clémence Fournier, Quentin Odet, Arthur Gouraud, Isabelle Bourget, Cédric Gaggioli, Sandy Giuliano, Frédéric Luciano, Olivier Léger, Zaki Sellam, Gilles Pagès   +12 more
wiley   +1 more source

On the importance of relative permeability data for estimating CO2 injectivity in brine aquifers [PDF]

, 2013
Performance assessment of possible CO2 storage schemes is often investigated through numerical simulation of the CO2 injection process. An important criterion of interest is the maximum sustainable injection rate.
Mathias, S.A., Bryant, S.L., Gluyas, J.G., Wilson, D., González Martínez de Miguel, G.J.   +4 more
core   +1 more source

UiO‐66 metal–organic frameworks in biomedicine: From structural tunability to bioimaging, photodiagnostics, and photodynamic cancer therapy

FEBS Open Bio, EarlyView.
UiO‐66(Zr) metal–organic frameworks are chemically stable, biocompatible, and highly tunable nanomaterials. Their modular structure enables controlled drug delivery, multimodal bioimaging, and light‐activated photodynamic therapy, supporting integrated diagnostic and therapeutic (theranostic) applications in cancer and biomedical research.
Veronika Huntošová, Grigorii Rakhalskii, Miroslav Almáši   +2 more
wiley   +1 more source

Dietary calcium decreases but short-chain fructo-oligosaccharides increase colonic permeability in rats [PDF]

, 2010
An increased intestinal permeability is associated with several diseases. Nutrition can influence gut permeability. Previously, we showed that dietary Ca decreases whereas dietary short-chain fructo-oligosaccharides (scFOS) increase intestinal ...
Schepens, M.A.A., Schepens, Marloes A. A.,, Bovee-Oudenhoven, I.M.J., Brummer, R.J.M., Willemsen, Linette E. M.,, Rijnierse, A., Bovee-Oudenhoven, Ingeborg M. J.,, Schonewille, A.J., Vink, C., Arjan J. Schonewille, Rijnierse, Anneke,, Willemsen, L.E.M., Anneke Rijnierse, Carolien Vink, Marloes A. A. Schepens, Meer, R., van de, Willemsen, L. E., Linette E. M. Willemsen, Vink, Carolien,, Bovee Oudenhoven, I.M., Brummer, R.J., Brummer, Robert,, Roelof van der Meer, van der Meer, Roelof,, van der Meer, R., Ingeborg M. J. Bovee-Oudenhoven, Robert-Jan M. Brummer, Schonewille, Arjan J.,   +27 more
core   +1 more source

Aquaporin‐3 and aquaporin‐5 impact the development of pancreatic ductal adenocarcinoma spheroids

FEBS Open Bio, EarlyView.
Schematic representation of the role of aquaporin‐3 (AQP3) and aquaporin‐5 (AQP5) in pancreatic ductal adenocarcinoma (PDAC). Both proteins are upregulated in PDAC and are associated with tumor progression and metastatic potential. Silencing AQP3 or AQP5 in PDAC spheroids results in decreased diameter, area, and overall growth, underscoring their key ...
Catarina Pimpão, Diogo M. Engrácia, Graça Soveral, Filipa Mendes   +3 more
wiley   +1 more source

A Fractal Gas-Water Relative Permeability Model in Geothermal Reservoirs

, 2019
Reliable gas-water relative permeability models are of significance for accurate numerical simulation for both petroleum and geothermal reservoirs. In this study, a modified Hagen-Poiseuille equation for gas/water flow was proposed based on the shell ...
Archer, Rosalind, Yu, Pengliang
core  

In-situ Estimation of Relative Permeability from Resistivity Measurements

, 2010
Relative permeability is one of the key parameters governing fluid flow through porous media. Determination of relative permeability is traditionally conducted in the laboratory using either recombined reservoir oil or laboratory oil at simulated ...
A.. Hajari, M.. Mudhhi, R. N. Horne, M.. Shapiro, K.. Li, S.. Ma   +5 more
core   +1 more source