Results 91 to 100 of about 631,049 (308)

Between personalized and racialized precision medicine : a relative resources perspective

open access: yes, 2020
Since the completion of the first human genome sequencing project in 2003, the potential for incorporating genomics into clinical practice in the pursuit of precision medicine has garnered a great amount of attention and interest.
Sun, Shirley
core   +1 more source

A practical demonstration on AMSU retrieval precision for upper tropospheric humidity by a non-linear multi-channel regression method [PDF]

open access: yesAtmospheric Chemistry and Physics, 2005
A neural network algorithm inverting selected channels from the Advance Microwave Sounding Unit instruments AMSU-A and AMSU-B was applied to retrieve layer averaged relative humidity.
C. Jiménez   +3 more
doaj  

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

open access: yesMolecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang   +12 more
wiley   +1 more source

Precision Teaching: Fast Practice or Merely More Practice Results in Better Learning?

open access: yes, 2009
Doughty, Chase and O'Shields (2004) reviewed the Precision Teaching literature which they point out claimed that Precision Teaching is superior in producing learning outcomes and they posed concerns about the lack of well designed research to support ...
Kong, Xiuyan
core  

An investigation of how relative precision of target encoding influences metacognitive performance. [PDF]

open access: yesAtten Percept Psychophys, 2021
Kellij S   +4 more
europepmc   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

open access: yesMolecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla   +9 more
wiley   +1 more source

Research on Relative Position and Attitude Measurement of Space Maglev Vibration Isolation Control System

open access: yesApplied Sciences
The working accuracy of space optical payloads, sensitive components, greatly depends on the pointing accuracy and stability of the platform. This article establishes a mathematical model for relative position and attitude measurement based on PSD and ...
Mao Ye, Jianyu Wang
doaj   +1 more source

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

open access: yesMolecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch   +13 more
wiley   +1 more source

Machining of Optical Surfaces in Brittle Materials using an Ultra-Precision Machine Tool [PDF]

open access: yes, 1995
Investigations of machining optical surfaces into brittle materials using an ultra precision machine tool are presented. The newly developed ultra precision NION machine is evaluated to gain a good appreciation of its operating performance.
Shore, Paul
core  

Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma

open access: yesMolecular Oncology, EarlyView.
The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic   +5 more
wiley   +1 more source

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