Results 131 to 140 of about 1,227,897 (305)
Molecular Oncology, EarlyView.This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska +13 more
wiley +1 more source
Quasiconvexity of virtual joins and separability of products in relatively hyperbolic groups
, 2023 A relatively hyperbolic group $G$ is said to be QCERF if all finitely generated relatively quasiconvex subgroups are closed in the profinite topology on $G$.
Minasyan, Ashot, Mineh, Lawk
core
Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining
Molecular Oncology, EarlyView.IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis +3 more
wiley +1 more source
Ratio-limit boundaries for random walks on relatively hyperbolic groups
, 2023 We study boundaries arising from limits of ratios of transition probabilities for random walks on relatively hyperbolic groups. We extend, as well as determine significant limitations of, a strategy employed by Woess for computing ratio-limit boundaries ...
Gekhtman, Ilya +2 more
core
Molecular Oncology, EarlyView.Many patients with urothelial cancer do not benefit from treatment with pembrolizumab, while at risk of severe side effects. Changes in the levels of circulating tumor DNA early during treatment, measured by a simple and affordable assay that can be easily implemented in the clinic, can be used as a prognostic tool to identify these patients.
Youssra Salhi +14 more
wiley +1 more source
World Journal of Surgical OncologyBackground Proximal gastrectomy is commonly performed for early upper-third gastric cancers; however, in no studies have the long-term outcomes of total and proximal gastrectomy been compared for clinically advanced upper-third gastric cancer.
Hayato Shimoyama +6 more
doaj +1 more source
MITF maintains genome stability in nonmelanocyte lineages
Molecular Oncology, EarlyView.MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir +13 more
wiley +1 more source
Properties of relatively free inverse semigroups
, 1986 The objective of this paper is to study structural properties of relatively free inverse semigroups in varieties of inverse semigroups. It is shown, for example, that if S S is combinatorial (i.e., H \mathcal {H}
N. R. Reilly, P. G. Trotter
core +1 more source
Dini Araştırmalar, 2015 In this article the experience of Andalus has been examined, in terms of “violence” which is relatively suited for an objective and descriptive expression.
Mehmet Özdemir
doaj
Acta Orthopaedica et Traumatologica TurcicaObjective: This study aimed to compare the biomechanical characteristics of conventional transosseous equivalent (TOE) techniques with those of the novel free independent double-row medial fixation method, using rigid polyurethane (PU) foam blocks to ...
Hakan Eskara +5 more
doaj +1 more source