Results 61 to 70 of about 1,227,897 (305)
Organoids in pediatric cancer research
FEBS Letters, EarlyView.Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley +1 more source
Cancer Communications, 2019 Background The National Comprehensive Cancer Network guidelines recommend intensity-modulated radiotherapy (IMRT) as the primary curative treatment for newly diagnosed nasopharyngeal carcinoma (NPC), but the radiation-related complications and relatively
You-Ping Liu +19 more
doaj +1 more source
Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?
FEBS Letters, EarlyView.This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes +3 more
wiley +1 more source
Left relatively convex subgroups
, 2021 Let G be a group and H be a subgroup of G. We say that H is left relatively convex in G if the left G-set G/H has at least one G-invariant order. When G is left orderable, this holds if and only if H is convex in G under some left ordering of G. We give
Sunic, Zoran
core
FEBS Letters, EarlyView.The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li +2 more
wiley +1 more source
FEBS Letters, EarlyView.We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee +3 more
wiley +1 more source
Food Technology and Biotechnology, 2019 In this study, a novel type of multi-armed polymer (poyltehylene glycol, PEG) magnetic graphene oxide (GO) composite (GO@Fe3O4@6arm-PEG-NH2) has been synthesized as a support for immobilization of horseradish peroxidase (HRP) for the first time.
Junhui Rong +6 more
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Relative hyperbolicity of free extensions of free groups
Transactions of the American Mathematical SocietyWe study relative hyperbolicity of free-by-free groups: Given a collection of outer automorphisms of the free group we give sufficient conditions for some power of these automorphisms to generate a free group so that the corresponding extension is relatively hyperbolic. Namely, if
Ghosh, Pritam, Gültepe, Funda
openaire +2 more sources
FEBS Letters, EarlyView.We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley +1 more source
A Whitehad algorithm for toral relatively hyperbolic groups [PDF]
, 2012 The Whitehead problem is solved in the class of toral relatively hyperbolic groups G (i.e. torsion-free relatively hyperbolic groups with abelian parabolic subgroups): there is an algorithm which, given two nite tuples (u1; ...
Kharlampovich, Olga +1 more
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