Results 131 to 140 of about 3,414,842 (239)

Targeting KRAS for cancer therapy

open access: yesBritish Journal of Pharmacology, EarlyView.
In recent years, therapeutics targeted against KRAS proto‐oncogene GTPase (KRAS)‐mutant cancers have seen significant progress. Herein we outline the biology and epidemiology of KRAS alterations at the lineage and allele levels, reviewing the clinical evidence for KRASG12C inhibition from the discovery of the recessive switch pocket to sotorasib ...
Jianlong Jia   +4 more
wiley   +1 more source

A low-cost modular PCB assembly for functional and in-circuit testing. [PDF]

open access: yesHardwareX
Puentes-Conde GM   +5 more
europepmc   +1 more source

Who Is a Sibling? Social Work Professionals' Views on Definitions of Siblinghood in Foster Care in England

open access: yesChild &Family Social Work, EarlyView.
ABSTRACT When children are placed in foster care, social work professionals decide whether they should and can be placed with their siblings. In England, this has become an important discussion within social work, as research has highlighted both the value of sibling co‐placement and the extent to which it often does not happen.
Florie J. E. Schmits, Esther Dermott
wiley   +1 more source

DiaActive protocol: A randomized controlled trial of cognitive‐motor multicomponent exercise to reduce fall rate in older adults with diabetes

open access: yesDiabetic Medicine, EarlyView.
Abstract Introduction Older adults with diabetes have an increased risk of falls due to neuropathy, impaired bone health and cardiovascular disease, resulting in significant morbidity and mortality. Conventional fall‐prevention programmes primarily target strength and balance, while cognitive‐motor integration, essential for safe mobility in complex ...
Aksayan Arunanthy Mahalingasivam   +4 more
wiley   +1 more source

Finality and Continuity: What Drives Bereaved Parents to Choose Posthumous Sperm Retrieval

open access: yesFamily Relations, EarlyView.
ABSTRACT Objective To explore bereaved parents' experience of deciding to pursue posthumous sperm retrieval (PHSR) and the meaning they associate with this choice. Background The death of a child profoundly disrupts the natural order of life, leaving parents with loss of meaning and identity.
Yael Doft   +3 more
wiley   +1 more source

Interdisciplinary child custody dispute resolution in Slovakia: Innovation without safeguards?

open access: yesFamily Court Review, EarlyView.
Abstract Slovakia introduced a multidisciplinary approach (MAC), inspired by the German Cochem model, to promote interdisciplinary coordination and parental agreements in child custody disputes. However, the national MAC methodology addresses domestic violence/intimate partner violence (DV/IPV) only marginally and does not structurally integrate ...
Slávka Karkošková, Barbora Burajová
wiley   +1 more source

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