Results 141 to 150 of about 3,414,842 (239)

Directional information flow in human frataxin defines allosteric pathways connecting the hydrophobic core to the iron‐binding ridge

open access: yesThe FEBS Journal, EarlyView.
Human frataxin deficiency causes Friedreich's ataxia, yet how iron‐binding events are communicated across the protein is unclear. Using transfer entropy analysis of molecular dynamics simulations, we identify buried hydrophobic core leucines (LEU136, LEU140) as the source of directional signaling toward the iron‐binding acidic ridge.
Kevser Kübra Kırboğa   +1 more
wiley   +1 more source

Insights into tandem dioxygenases—copper radical oxidases in fungal Phytopathogens of the Colletotrichum acutatum species complex

open access: yesThe FEBS Journal, EarlyView.
In Colletotrichum acutatum species complex, conserved ring‐cleavage dioxygenases located adjacent to AA5_2 enzymes were investigated as potential redox partners. Biochemical analyses identified the dioxygenases as intradiol‐cleaving enzymes preferentially oxidizing methyl‐substituted catechols, while AA5_2 enzymes displayed weak alcohol oxidase ...
Radka Končitíková   +7 more
wiley   +1 more source

“My Wife Says…”: Epistemic Injustice in the Rationale of Parenting Responsibilities Among Academic Parents

open access: yesGender, Work &Organization, EarlyView.
ABSTRACT The event of having a child for an academic is associated with lower research productivity for women, even when the parenting burden is shared by both male and female parents. Universities and research organizations commonly employ “family‐friendly” policies to simultaneously ease work expectations and provide flexibility in work patterns ...
Gemma Elizabeth Derrick   +6 more
wiley   +1 more source

Scalp Dysesthesia: Emerging Pathophysiologic Insights and Therapeutic Implications

open access: yesInternational Journal of Dermatology, EarlyView.
Scalp dysesthesia is a chronic condition diagnosed through exclusion. This scoping review synthesized data from 59 patients to identify recurrent clinical features, comorbidities, and management strategies that may support earlier diagnosis. Emerging patterns suggest that neuronal sensitization may underlie common symptoms.
Aditya K. Gupta   +4 more
wiley   +1 more source

Exploring Nurses' Practices in Supporting Sexual Wellbeing of People Living With Inflammatory Bowel Disease: An International Qualitative Study

open access: yesJournal of Advanced Nursing, EarlyView.
ABSTRACT Aim To explore how nurses across international settings support the sexual wellbeing of people living with inflammatory bowel disease through their clinical practice. Design Qualitative descriptive study. Methods Online semi‐structured interviews and one focus group were conducted with nurses from Australia, Canada, Japan, the Republic of ...
Sayaka Wakai   +4 more
wiley   +1 more source

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