Results 61 to 70 of about 1,717,917 (266)

Transcriptional profiling of circulating extracellular vesicles from prebiopsy prostate cancer patients

open access: yesMolecular Oncology, EarlyView.
RNA profiling of circulating extracellular vesicles (EVs) from blood samples of men undergoing prostate biopsy identifies transcripts associated with clinically significant prostate cancer. Integrative analysis with public tumor datasets links EV‐derived gene signatures to tumor stage and progression‐free survival, highlighting CASP3, XRCC2, and RIT1 ...
Stefan Werner   +14 more
wiley   +1 more source

Death certificate: Herbert Dates

open access: yes, 1917
This is a photograph of the death certificate for Herbert Dates, deceased on 1917-12-17, filed with the Arkansas Department of Health by the Ruebel Funeral Home in Little Rock.Transcribed.
Ruebel Funeral Home (Little Rock, Ark.)
core  

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

open access: yesMolecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober   +16 more
wiley   +1 more source

Branch-and-bound algorithm to minimize the total completion time on two dedicated processors

open access: yesOperations Research Perspectives
In this paper, we propose an exact method for solving the problem of scheduling multiprocessor tasks on two dedicated processors with release dates. In this problem, we have three subsets of tasks, where these tasks need one or two dedicated processors ...
Adel Kacem, Abdelaziz Dammak
doaj   +1 more source

Approximation Results for Preemptive Stochastic Online Scheduling [PDF]

open access: yes
We present first constant performance guarantees for preemptive stochastic scheduling to minimize the sum of weighted completion times. For scheduling jobs with release dates on identical parallel machines we derive policies with a guaranteed performance
Megow, Nicole, Vredeveld, Tjark
core  

Cancer‐associated mutations in endometriosis reframe a benign disease through molecular oncology

open access: yesMolecular Oncology, EarlyView.
This review aims to comprehensively analyse cancer‐associated somatic mutations (CAMs) present in endometriotic lesions, emphasizing their biological roles, spatial distribution and implications for translational applications in medicine. By contextualizing a benign state within a genomic framework, this analysis seeks to establish its value as a ...
Clarissa Mujacic   +15 more
wiley   +1 more source

24 Working with dates and times Contents

open access: yes, 2014
24.3 Displaying dates and times 24.4 Typing dates and times (datetime ...
Inputting Dates
core  

CEACAM1 participation in breast cancer progression

open access: yesMolecular Oncology, EarlyView.
In invasive breast cancer (BC), CEACAM1 shifts from an apical to a uniform membranous/cytoplasmic pattern, or is lost, as tumors dedifferentiate, inversely tracking the Ki‐67 proliferative index. In MCF‐7 cells, only CEACAM1‐4L suppresses proliferation, repressing cell cycle and growth factor genes.
Mykola Lyndin   +3 more
wiley   +1 more source

Photocrosslinked microgels for oral delivery of macromolecular based-therapeutics

open access: yes, 2015
In this work we present the fabrication of planar micro-hydrogels serving as vehicle for oral delivery of poorly bioavailable drugs. Microfabricated gels were prepared by means of selective exposure of aqueous solutions of poly(vinylpyrrolidone) (PVP) to
Faralli, A.   +7 more
core  

Somatostatin receptor 4 (SSTR4) is a tumor suppressor in cutaneous and head & neck squamous cell carcinomas

open access: yesMolecular Oncology, EarlyView.
This study identifies somatostatin receptor 4 (Sstr4) as a critical tumor suppressor against skin and head/neck cancers (HNSCC, cSCC, and BCC). The loss of Sstr4 removes a check on cell growth, causing hyperactivation of the MAPK‐ERK signaling pathway (↑).
Ali Taqvi   +6 more
wiley   +1 more source

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