Results 101 to 110 of about 5,221,373 (330)

Function‐driven design of a surrogate interleukin‐2 receptor ligand

FEBS Letters, EarlyView.
Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang, Zelin Cheng, Teng Li, Fulian Wang, Liangminghui Zhang, Xiuxiu He, Lili Liu, Wei Wang, Aibin Liang, Guang Yang   +9 more
wiley   +1 more source

Quantitative Evaluation of Debris Removal from NiTi Rotary Endodontic Instruments After Different Cleaning Procedures

Dentistry Journal
Objectives: Endodontic instruments require thorough decontamination and sterilization before use and reuse to ensure the safety and success of treatments. However, standardized protocols are lacking.
Luigi Generali, Paolo Generali, Pio Bertani, Francesco Cavani, Vittorio Checchi, Tommaso Filippini, Federica Veneri   +6 more
doaj   +1 more source

Measuring the relevance of retrieved images in search engines based on Persian language writing styles

Iranian Journal of Information Processing & Management, 2022
The aim of this study was to investigate the image retrieval from selected search engines according to the written and semantic features of Persian language and determine their relevance using recall and precision formulas and to identify the most ...
Yaghub Norouzi, Hoda Homavandi, Bent-ol hoda khabbazan   +2 more
doaj  

The relevance of early cognitive diagnosis in middle age or the threshold of old age—for a better quality of life for the long‐lived [PDF]

, 2021
Marcella Bianca Neves, Flamínia Manzano Moreira Lodovici   +1 more
openalex   +1 more source

An upstream open reading frame regulates expression of the mitochondrial protein Slm35 and mitophagy flux

FEBS Letters, EarlyView.
This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva, Ariann E. Mendoza‐Martínez, P. Abril Medina‐Flores, Carlos Campero‐Basaldua, Alexander DeLuna, Soledad Funes   +5 more
wiley   +1 more source

Proteomic Comparison between Periodontal Pocket Tissue and Other Oral Samples in Severe Periodontitis: The Meeting of Prospective Biomarkers

Sci
Periodontitis is characterized by gingival regression, alveolar bone resorption and the development of deep periodontal pockets that, if left untreated, can lead to tooth loss. Currently, specific biomarkers are needed for the early, objective diagnosis,
Elisa Bellei, Emanuela Monari, Carlo Bertoldi, Stefania Bergamini   +3 more
doaj   +1 more source

PICALM::MLLT10 translocated leukemia

FEBS Letters, EarlyView.
This comprehensive review of PICALM::MLLT10 translocated acute leukemia provides an in‐depth review of the structure and function of CALM, AF10, and the fusion oncoprotein (1). The multifaceted molecular mechanisms of oncogenesis, including nucleocytoplasmic shuttling (2), epigenetic modifications (3), and disruption of endocytosis (4), are then ...
John M. Cullen, Antonia C. Nakatsugawa, Natalie Barton, Henry Haines, Gary S. Stein, Janet L. Stein, Daniel S. Wechsler, Jessica L. Heath   +7 more
wiley   +1 more source

Critical importance of patient-reported outcomes for a comprehensive assessment of psoriatic arthritis patients

Frontiers in Medicine
IntroductionPsoriatic arthritis (PsA) is a heterogeneous, chronic inflammatory disease that negatively impacts patients’ quality of life. Patient-reported outcome measures (PROMs) are used to capture patient perspectives in disease assessment, and ...
Marika Lo Monaco, Marika Lo Monaco, Raffaella Mallaci Bocchio, Giuseppe Natoli, Annarita Giardina, Ignazio Cangemi, Salvatore Scibetta, Christiano Argano, Salvatore Corrao, Salvatore Corrao   +9 more
doaj   +1 more source

PESTOL - Framework for «Project Evaluation on Strategic, Tactical and Operational Levels»

International Journal of Information Systems and Project Management, 2022
The paper focuses on the development of the ex-post conceptual holistic framework for Project Evaluation on Strategic, Tactical and Operational Levels, the PESTOL model, by reviewing different definitions of project success and/or failure and combining ...
Youcef J-T. Zidane, Agnar Johansen, Bassam A. Hussein, Bjørn Andersen   +3 more
doaj  

Correction: Prospective study on the clinical relevance of 18F-DOPA positron emission tomography/computed tomography in patients with medullary thyroid carcinoma [PDF]

, 2022
Inés Califano, Fabián Pitoia, Roxana Chirico, Alejandra de Salazar, María Bastianello   +4 more
openalex   +1 more source