Results 101 to 110 of about 2,027,234 (292)

Response Essay: Some Observations on Professor Schwartz\u27s Foundation Theory of Evidence [PDF]

, 2012
Professor David Schwartz\u27s A Foundation Theory of Evidence posits an intriguing new way to look at Evidence. It asserts that offered evidence must meet a tripartite requirement before it can be relevant. The tripartite requirement is that the evidence
Rothstein, Paul F
core   +1 more source

Adaptaquin is selectively toxic to glioma stem cells through disruption of iron and cholesterol metabolism

Molecular Oncology, EarlyView.
Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié, Davod R. Shah, Eliane E. S. Brechbühl, Michael McNicholas, Zhaoyang Xu, John H. Stockley, Laura Morcom, Diana Gold Diaz, Gemma C. Girdler, Rachel V. Seear, Gabriel Balmus, Rajiv R. Ratan, Harry Bulstrode, James A. Nathan, Manav Pathania, Kevin M. Brindle, David H. Rowitch   +16 more
wiley   +1 more source

Argumentation and Cognition: Can Pragma-Dialectics Interplay with Pragma-Semantics?

Critical Approaches to Discourse Analysis across Disciplines, 2007
This paper addresses the possibility of a cognitive account of argumentation, by focusing on a tentative interplay between one of today’s most influential theories of argumentation – van Eemeren and Grootendorst’s Pragma-Dialectics – and Relevance Theory.
Steve Oswald
doaj  

Towards a pragmatics of non-fictional narrative truth: Gricean and relevance-theoretic perspectives

Stellenbosch Papers in Linguistics Plus, 2016
From a linguistic perspective, ‘truth’ is undoubtedly a pragmatic notion, as the truth of an utterance is not determined solely by its linguistic meaning, but is dependent upon the context in which it is uttered.
Berghoff, Robyn, Huddlestone, Kate
doaj   +1 more source

relevance theory explaining verbal communication

Stellenbosch Papers in Linguistics Plus, 2013
No ...
Sinclair, M, Winckler, WK
openaire   +3 more sources

On the use of stochastic differential geometry for non-equilibrium thermodynamics modeling and control

, 2012
We discuss the relevance of geometric concepts in the theory of stochastic differential equations for applications to the theory of non-equilibrium thermodynamics of small systems.
Muratore-Ginanneschi, Paolo
core   +1 more source

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source

Aggressive prostate cancer is associated with pericyte dysfunction

Molecular Oncology, EarlyView.
Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero, Ane Martinez‐Larrinaga, Joaquim Grego‐Bessa, Saioa Garcia‐Longarte, Hielke van Splunder, Ianire Astobiza, Amaia Ercilla, Laura Bozal‐Basterra, Isabel Mendizabal, Pilar Villacampa, Arkaitz Carracedo, Mariona Graupera   +11 more
wiley   +1 more source

Lying and Misleading within the Philosophy of Language: A Relevance-Theoretic Perspective [PDF]

Anglica. An International Journal of English Studies, 2017
The aim of the paper is to examine the lying/misleading distinction from a relevance-theoretic perspective (cf. Sperber and Wilson [1986] 1995; 2004; Wilson and Sperber 2002; 2012).
Marta Kisielewska-Krysiuk
doaj  

Completeness of relevant quantification theories.

Notre Dame Journal of Formal Logic, 1974
In [20], Meyer and Dunn answered affirmatively for the relevant sentential logics E and R the question, "Is the rule y, 'From v-A and f-Av5, to infer B,' admissible?" This result, which confirmed an old conjecture of Anderson and Belnap, establishes the weak completeness of these and a number of related logics.
Meyer, Robert K., Dunn, J. Michael, Leblanc, Hugues   +2 more
openaire   +4 more sources