Results 71 to 80 of about 224,870 (256)

Biblical Performance Criticism: Survey and Prospects

open access: yesReligions, 2019
Biblical Performance Criticism (BPC) analyzes communication events of biblical traditions for audiences. Every communication event of a tradition has four aspects: a communicator, traditions re-expressed, an audience, and a social situation.
Peter S. Perry
doaj   +1 more source

In vitro models of cancer‐associated fibroblast heterogeneity uncover subtype‐specific effects of CRISPR perturbations

open access: yesMolecular Oncology, EarlyView.
Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra   +10 more
wiley   +1 more source

Bible translation and relevance theory [PDF]

open access: yesStellenbosch Papers in Linguistics Plus, 2014
No abstract available.
openaire   +2 more sources

Cis‐regulatory and long noncoding RNA alterations in breast cancer – current insights, biomarker utility, and the critical need for functional validation

open access: yesMolecular Oncology, EarlyView.
The noncoding region of the genome plays a key role in regulating gene expression, and mutations within these regions are capable of altering it. Researchers have identified multiple functional noncoding mutations associated with increased cancer risk in the genome of breast cancer patients.
Arnau Cuy Saqués   +3 more
wiley   +1 more source

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

open access: yesMolecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice   +16 more
wiley   +1 more source

LINC01116, a hypoxia‐lncRNA marker of pathological lymphangiogenesis and poor prognosis in lung adenocarcinoma

open access: yesMolecular Oncology, EarlyView.
The LINC01116 long noncoding RNA is induced by hypoxia and associated with poor prognosis and high recurrence rates in two cohorts of lung adenocarcinoma patients. Here, we demonstrate that besides its expression in cancer cells, LINC01116 is markedly expressed in lymphatic endothelial cells of the tumor stroma in which it participates in hypoxia ...
Marine Gautier‐Isola   +12 more
wiley   +1 more source

Argumentation and Cognition: Can Pragma-Dialectics Interplay with Pragma-Semantics?

open access: yesCritical Approaches to Discourse Analysis across Disciplines, 2007
This paper addresses the possibility of a cognitive account of argumentation, by focusing on a tentative interplay between one of today’s most influential theories of argumentation – van Eemeren and Grootendorst’s Pragma-Dialectics – and Relevance Theory.
Steve Oswald
doaj  

Towards a pragmatics of non-fictional narrative truth: Gricean and relevance-theoretic perspectives

open access: yesStellenbosch Papers in Linguistics Plus, 2016
From a linguistic perspective, ‘truth’ is undoubtedly a pragmatic notion, as the truth of an utterance is not determined solely by its linguistic meaning, but is dependent upon the context in which it is uttered.
Berghoff, Robyn, Huddlestone, Kate
doaj   +1 more source

relevance theory explaining verbal communication

open access: yesStellenbosch Papers in Linguistics Plus, 2013
No ...
Sinclair, M, Winckler, WK
openaire   +3 more sources

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

open access: yesMolecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon   +13 more
wiley   +1 more source

Home - About - Disclaimer - Privacy