Results 41 to 50 of about 10,008 (302)
Molecular Oncology, EarlyView.Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson +9 more
wiley +1 more source
Interpreting the effects of DNA polymerase variants at the structural level
Molecular Oncology, EarlyView.Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi +7 more
wiley +1 more source
Truthmaker Semantics for Relevant Logic [PDF]
Journal of Philosophical Logic, 2020 AbstractI develop and defend a truthmaker semantics for the relevant logic R. The approach begins with a simple philosophical idea and develops it in various directions, so as to build a technically adequate relevant semantics. The central philosophical idea is that truths are true in virtue of specific states. Developing the idea formally results in a
openaire +1 more source
A Routley-Meyer semantics for relevant logics including TWR plus the disjunctive syllogism [PDF]
[EN] We provide Routley-Meyer type semantics for relevant logics including Contractionless Ticket Entailment TW (without the truth constant t and o) plus reductio R and Ackermann’s rule \gamma (i.e., disjunctive syllogism).
Robles Vázquez, Gemma +1 more
core +1 more source
Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining
Molecular Oncology, EarlyView.IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis +3 more
wiley +1 more source
Logic and Logical Philosophy, 2019 In this paper, a connexive extension of the Relevance logic R→ was presented. It is defined by means of a natural deduction system, and a deductively equivalent axiomatic system is presented too. The goal of such an extension is to produce a logic with stronger connection between the antecedent and the consequent of an implication.
openaire +3 more sources
Directed evolution of enzymes at the crossroads of tradition and innovation
FEBS Open Bio, EarlyView.An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova +2 more
wiley +1 more source
Relevant Logics Obeying Component Homogeneity [PDF]
, 2018 This paper discusses three relevant logics that obey Component Homogeneity - a principle that Goddard and Routley introduce in their project of a logic of significance. The paper establishes two main results.
Roberto Ciuni +5 more
core +1 more source
Circulation Patterns, Abundance and Scarcity: Film Availability in the Online Era
Media Industries, 2022 Online circulation, diversity of content in video-on-demand (VOD) catalogs, and access to markets are increasingly relevant research subjects. Netflix, Amazon, and many other VOD platforms have an important role to play in making content available, but ...
roderik smits
doaj +2 more sources
Notre Dame Journal of Formal Logic, 1986 This is a continuation of the author's investigations [J. Symb. Logic 49, 334-342 (1984; Zbl 0586.03017)] of logics designed to overcome a perceived tension between extensional and intensional features of relevant logics. (This issue has been discussed frequently by relevant logicians. \textit{R. K. Meyer} and \textit{M. A.
openaire +2 more sources