Results 111 to 120 of about 24,217,389 (293)

Integration of Serum Neurofilament Light Chain and Cortical Dysfunction Improves Diagnostic Accuracy in ALS

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To determine whether integration of serum neurofilament light chain (NfL) and cortical dysfunction improves diagnostic accuracy in amyotrophic lateral sclerosis (ALS) when applied alongside the Gold Coast criteria (GCC). Methods In this prospective study, 148 participants with suspected ALS were recruited (101 ALS and 47 with ALS ...
Aicee Dawn Calma   +16 more
wiley   +1 more source

Characterizing Cutaneous α‐Synuclein Deposition and Seeding Activity in Parkinson's Disease Subtypes

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Cutaneous phosphorylated α‐synuclein (p‐syn) and α‐synuclein seeding activity are promising biomarkers for Parkinson's disease (PD), but their clinical value remains uncertain due to disease heterogeneity. This study evaluates these two biomarkers in PD patients to inform phenotype‐specific diagnosis and disease severity assessment ...
Yuting Jin   +8 more
wiley   +1 more source

Blood RNA Biomarker Signatures for Early Diagnosis and Prognosis in Ischemic and Hemorrhagic Stroke: The IBIS‐CT1 Study

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To evaluate the expression of nine blood RNA biomarkers in a clinical trial based on genes previously identified in an experimental monkey model of stroke for diagnosis feasibility and prognostication. Methods IBIS‐CT1 was a prospective longitudinal study enrolling patients with ischemic stroke (IS) or intracerebral hemorrhage (ICH ...
Salomé Retailleau   +11 more
wiley   +1 more source

Reliability Based Design Optimization by using Metamodels

open access: yes, 2018
This paper summarize our work so far on reliability based design optimization (RBDO) by using metamodels and present some new ideas on RBDO using support vector machines.
Strömberg, Niclas,
core   +1 more source

Reliability-based design optimization analysis of a piezoelectric engine

open access: yesIncertitudes et Fiabilité des Systèmes Multiphysiques, 2018
Bouchaïb Radi, Abdelkhalak El Hami
doaj   +1 more source

RETRACTED : Mechanical and structural reliability based algorithm optimization

open access: yesJournal of Materials and Engineering Structures, 2019
This article has been retracted at the request of the Editors-in-Chief, according to the Publication Ethics Policy and Publication Malpractice Statement.
Ahmed SAHLI, Sara SAHLI
doaj  

A single loop reliability-based design optimization using EPM and MPP-based PSO

open access: yesLatin American Journal of Solids and Structures
A reliability-based design optimization (RBDO) incorporates a probabilistic analysis with an optimization technique to find a best design within a reliable design space.
Kuo-Wei Liao, Gautama Ivan
doaj   +1 more source

Baseline Neuroinflammation Stratifies TSPO‐PET Response to Disease‐Modifying Therapy in Multiple Sclerosis

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To investigate which baseline clinical and imaging characteristics best predict TSPO‐PET‐measurable reduction in glial activation following treatment of multiple sclerosis (MS), to utilize this information for designing more efficient biomarker‐based clinical trials targeting glial activation.
Marlene T. Morch   +5 more
wiley   +1 more source

Efficient reliability-based optimization using a combined metamodel and FE-based strategy

open access: yes, 2014
It is essential to consider the uncertainties in design variables of an optimization process in order to create a reliable design. The computational effort required to perform reliability-based optimization of complex engineering problems is very high ...
Shetty, Sandeep,
core  

Predictive Value of Composite Inflammatory Markers for Stroke Prognosis: A Prospective Cohort Study

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Novel composite inflammatory markers' role in stroke prognosis is understudied, and the best predictor is unclear, requiring further exploration. Objectives This study aimed to systematically evaluate the associations of 6 novel composite inflammatory markers on stroke prognosis.
Bing Wu   +7 more
wiley   +1 more source

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