Results 91 to 100 of about 24,217,389 (293)

An incremental shifting vector approach for reliability-based design optimization [PDF]

open access: yes, 2016
© 2015, Springer-Verlag Berlin Heidelberg. This paper proposes a decoupling algorithm for reliability-based design optimization (RBDO) with high performance in terms of efficiency and convergence, which provides an effective tool for reliability design ...
Zhou, YS   +4 more
core   +1 more source

Genetic dissection of human ABCE1 in yeast reveals separable requirements for ribosome recycling and suppression of aberrant reinitiation

open access: yesFEBS Open Bio, EarlyView.
Human ABCE1 cannot functionally replace its yeast ortholog. Yeast–human chimera analysis identified NBD1 as a major interspecies barrier. Genetic screening yielded hABCE1 revertants that rescue yeast viability but fail to suppress aberrant translation reinitiation in the 3′ UTR.
Eriko Nakata   +3 more
wiley   +1 more source

TRPML1 agonist ML‐SA5 attenuates pulmonary fibroblast activation by suppressing mTOR and restoring autophagic flux

open access: yesFEBS Open Bio, EarlyView.
TGF‐β1 stimulation downregulates lysosomal channel TRPML1 in pulmonary fibroblasts. The TRPML1 agonist ML‐SA5 suppressed fibroblast‐to‐myofibroblast activation and collagen production. Mechanistically, ML‐SA5 inhibited mTOR phosphorylation, restored autophagic flux, and its effects were enhanced by rapamycin (mTOR inhibitor) and reversed by MHY1485 ...
Jiatong Yao   +10 more
wiley   +1 more source

Ultraviolet-A LED Based on Quantum-Disks-In-AlGaN-Nanowires—Optimization and Device Reliability

open access: yesIEEE Photonics Journal, 2018
Group-III nitride-based ultraviolet (UV) quantum-disks (Qdisks) nanowires (NWs) light-emitting diodes grown on silicon substrates offer a scalable, environment-friendly, compact, and low-cost solution for numerous applications in solid-state lighting ...
Bilal Janjua   +10 more
doaj   +1 more source

Clinical Outcomes of SEEG‐Guided Radiofrequency Thermocoagulation in Children With Focal Drug‐Resistant Epilepsy: A Multicenter Real‐World Study

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Stereoelectroencephalography‐guided radiofrequency thermocoagulation (SEEG‐RFTC) has emerged as a safe and effective minimally invasive treatment for children with drug‐resistant focal epilepsy. Although evidence from real‐world studies remains limited, numerous pediatric cases have demonstrated promising outcomes. This retrospective
Weitao Chen   +7 more
wiley   +1 more source

ADVANCES IN RELIABILITY OPTIMIZATION OF MULTI-STATE SYSTEM

open access: yesJixie qiangdu, 2016
Multi-state system reliability is very important for complex systems which have a range of performance levels from perfect functioning to complete failure.
LI ChunYang, CHEN ShouHua, LI LingWei
doaj  

Multidisciplinary Reliability Design Optimization Modeling Based on SysML

open access: yesApplied Sciences
Model-Based Systems Engineering (MBSE) supports the system-level design of complex products effectively. Currently, system design and optimization for complex products are two distinct processes that must be executed using different software or platforms,
Qiang Zhang, Jihong Liu, Xu Chen
doaj   +1 more source

High‐Resolution MRI Revealed Different Etiology‐Specific Associations With Cerebral Infarction in Adult Moyamoya Vasculopathy

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective High‐resolution MRI enables detailed assessment of intracranial vessel wall pathology in moyamoya vasculopathy. We aimed to classify adult moyamoya vasculopathy etiologies using high‐resolution MRI and to examine subtype‐specific associations between high‐resolution MRI features and ischemic infarction.
Guangsong Han   +8 more
wiley   +1 more source

Continuum topology optimization with non-probabilistic reliability constraints based on multi-ellipsoid convex model

open access: yes, 2009
Using a quantified measure for non-probab ilistic reliability based on the multi-ellipsoid convex model, the topology optimization of continuum structures in presence of uncertain-but-bounded parameters is investigated.
Kang, Z, Luo, Z, Luo, Y, Li, A
core   +1 more source

Discrete multicriteria reliability-based optimization of spatial trusses

open access: yesComputer Assisted Methods in Engineering and Science, 2022
The paper presents problem of discrete multicriteria optimization of two-layer regular orthogonal spatial trusses. Three criteria of evaluation are taken into account, namely: minimum of weight, maximum of reliability and maximum of stiffness of the ...
Stefan Jendo   +2 more
doaj  

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