Results 81 to 90 of about 3,372,734 (329)

Two decades review of reliability-based topology optimization developments

Incertitudes et Fiabilité des Systèmes Multiphysiques, 2022
Ghais Kharmanda, Hasan Mulki
doaj   +1 more source

Maximizing Service Reliability in Distributed Computing Systems with Random Node Failures: Theory and Implementation [PDF]

, 2010
In distributed computing systems (DCSs) where server nodes can fail permanently with nonzero probability, the system performance can be assessed by means of the service reliability, defined as the probability of serving all the tasks queued in the DCS ...
Dhakal, Sagar, Hayat, Majeed M., Pezoa, Jorge E.   +2 more
core   +1 more source

Complex network analysis of water distribution systems

, 2011
This paper explores a variety of strategies for understanding the formation, structure, efficiency and vulnerability of water distribution networks. Water supply systems are studied as spatially organized networks for which the practical applications of ...
Jeffrey, P., Yazdani, A.
core   +1 more source

Pre‐analytical optimization of cell‐free DNA and extracellular vesicle‐derived DNA for mutation detection in liquid biopsies

Molecular Oncology, EarlyView.
Pre‐analytical handling critically determines liquid biopsy performance. This study defines practical best‐practice conditions for cell‐free DNA (cfDNA) and extracellular vesicle–derived DNA (evDNA), showing how processing time, storage conditions, tube type, and plasma input volume affect DNA integrity and mutation detection.
Jonas Dohmen, Lucrezia De Santis, Bret M. Stephens, Vincent Bernard, Jörg C. Kalff, Lara Braun, Phillipp Leyendecker, Johannes Röttgen, Daniel Weissinger, Anirban Maitra, Paola A. Guerrero, Alexander Semaan   +11 more
wiley   +1 more source

Composite laminate tailoring with probabilistic constraints and loads [PDF]

A reliability-based structural synthesis procedure was developed to tailor laminates to meet reliability-based (ply) strength requirements and achieve desirable laminate responses.
Chamis, C. C., Thanedar, P. B.
core   +1 more source

A New Efficient Stochastic Energy Management Technique for Interconnected AC Microgrids

, 2018
Cooperating interconnected microgrids with the Distribution System Operation (DSO) can lead to an improvement in terms of operation and reliability.
Dabbaghjamanesh, Morteza, Fard, Abdollah Kavousi, Ferdowsi, Farzad, Mehraeen, Shahab   +3 more
core   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Reliability-based buckling optimization with an accelerated Kriging metamodel for filament-wound variable angle tow composite cylinders

Composite structures, 2020
A reliability-based optimization framework is introduced and used to design filament-wound cylindrical shells with variable angle tow. Seven design cases are investigated to enable a comparison between constant-stiffness and variable angle tow designs ...
Zhihua Wang, J. H. S. Almeida, L. St-Pierre, Zhonglai Wang, S. Castro   +4 more
semanticscholar   +1 more source

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

Molecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova, Michele Montrone, Uday Rangaswamy, Francesco Diversi, Irene Schiavo, Denise Ferrarini, Roberta Di Florio, Irene Longo, Michele Coscia, Nicola Zamboni, Giorgia Demontis, Lisa Veghini, Vincenzo Corbo, Remo Sanges, Paul Heppenstall   +14 more
wiley   +1 more source

Differential expression of cancer‐related genes supports prediction of poor response to first‐line treatments in T‐ALL pediatric patients with high minimal residual disease

Molecular Oncology, EarlyView.
In the present work, we have identified a transcriptional signature based on the differential expression of six genes (BCL2&MAST4, HSH2D&LAT2, METRN&PITPNM2) that would facilitate the early detection of T‐cell acute lymphoblastic leukemia (T‐ALL) patients prone to a poor treatment response and could be implemented at diagnosis, along with other risk ...
Antonio Lahera, Laura Vela‐Martín, Pablo Fernández‐Navarro, José Luis López‐Lorenzo, Javier Cornago, Pilar Llamas, Eduardo Pérez‐Gómez, José Luis Marín‐Rubio, Manuel Fresno, Javier Santos, José Fernández‐Piqueras, María Villa‐Morales   +11 more
wiley   +1 more source