Results 61 to 70 of about 3,372,734 (329)

Reliability Topology Optimization of Collaborative Design for Complex Products Under Uncertainties Based on the TLBO Algorithm

Engineering, 2023
The topology optimization design of complex products can significantly improve material and power savings, and reduce inertial forces and mechanical vibrations effectively.
Zhaoxi Hong, Xiangyu Jiang, Yixiong Feng, Qinyu Tian, Jianrong Tan   +4 more
doaj   +1 more source

Genetic embedded matching approach to ground states in continuous-spin systems

, 2007
Due to an extremely rugged structure of the free energy landscape, the determination of spin-glass ground states is among the hardest known optimization problems, found to be NP-hard in the most general case.
A. Gibbons, A. J. Bray, A. K. Hartmann, A. K. Hartmann, C. H. Papadimitriou, D. J. Wales, E. Castillo, G. Toulouse, J. Edmonds, K. F. Pál, M. Mezard, Martin Weigel, N. Kawashima, P. A. Ferrari, S. Alder, S. Geman, S. S. Plotkin, W. Feller, Z. Michalewicz   +18 more
core   +1 more source

Structural biology of ferritin nanocages

FEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source

In vitro models of cancer‐associated fibroblast heterogeneity uncover subtype‐specific effects of CRISPR perturbations

Molecular Oncology, EarlyView.
Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra, Shamsudheen Karuthedath Vellarikkal, Lixia Li, Hong Sun, Khoa Nguyen, Amber Montano, Suchitra Natarajan, Federica Piccioni, Alex Michael Tamburino, Xin Yu, Aleksandra Katarzyna Olow   +10 more
wiley   +1 more source

Uncertainty propagation in multi-agent systems for multidisciplinary optimization problems [PDF]

, 2013
International audienceBecause of uncertainties on models and variables, deterministic multidisciplinary optimization may achieve under-sizing (without design margins) or over-sizing (with arbitrary design margins).
Bes, Christian, Gogu, Christian, Jaeger, Laure, Jorquera, Tom, Lemouzy, Sylvain, Segonds, Stéphane   +5 more
core   +1 more source

Reliability-based design using variable-fidelity optimization [PDF]

Structure and Infrastructure Engineering, 2005
Competitive marketplaces have driven the need for simulation-based design optimization to produce efficient and cost-effective designs. However, such design practices typically do not take into account model uncertainties or manufacturing tolerances.
Shawn Gano, Harish Agarwal, John Renaud, Andres Tovar   +3 more
openaire   +1 more source

LDAcoop: Integrating non‐linear population dynamics into the analysis of clonogenic growth in vitro

Molecular Oncology, EarlyView.
Limiting dilution assays (LDAs) quantify clonogenic growth by seeding serial dilutions of cells and scoring wells for colony formation. The fraction of negative wells is plotted against cells seeded and analyzed using the non‐linear modeling of LDAcoop.
Nikko Brix, Daniel Samaga, Katharina Gehr, Benedek Dankó, Mohamed Schumann, Guido Drexler, Ahmed Alnatsha, Georg Beyer, Ujjwal Mahajan, Martin Selmansberger, Julia Mayerle, Claus Belka, Horst Zitzelsberger, Kirsten Lauber   +13 more
wiley   +1 more source

Reliability-Based Topology Optimization with a Proportional Topology for Reliability

Aerospace
This research proposes an efficient technique for reliability-based topology optimization (RBTO), which deals with uncertainty and employs proportional topology optimization (PTO) to achieve the optimal reliability structure. The recent technique, called
Noppawit Kumkam, Suwin Sleesongsom
doaj   +1 more source

Exploring tradeoffs in pleiotropy and redundancy using evolutionary computing

, 2004
Evolutionary computation algorithms are increasingly being used to solve optimization problems as they have many advantages over traditional optimization algorithms.
Abbott, Derek, Allison, Andrew, Berryman, Matthew J., Khoo, Wei-Li, Nguyen, Hiep, O'Neill, Erin   +5 more
core   +1 more source

Infrared laser sampling of low volumes combined with shotgun lipidomics reveals lipid markers in palatine tonsil carcinoma

Molecular Oncology, EarlyView.
Nanosecond infrared laser (NIRL) low‐volume sampling combined with shotgun lipidomics uncovers distinct lipidome alterations in oropharyngeal squamous cell carcinoma (OPSCC) of the palatine tonsil. Several lipid species consistently differentiate tumor from healthy tissue, highlighting their potential as diagnostic markers.
Leonard Kerkhoff, Manuela Moritz, Dennis Eggert, Anna Worthmann, Joerg Heeren, Henrike Zech, Till S. Clauditz, Waldemar Wilczak, Hartmut Schlüter, Christian S. Betz, Arne Böttcher, Jan Hahn   +11 more
wiley   +1 more source