Results 61 to 70 of about 24,217,389 (293)

Preoperative circulating tumor cells integrated with imaging analysis for prognostic evaluation in head and neck squamous cell carcinoma

Molecular Oncology, EarlyView.
Detecting circulating tumor cells (CTCs) in blood before surgery may help predict outcomes in patients with head and neck squamous cell carcinoma (HNSCC). Here, we show when combined with tumor size and lymph node involvement from routine imaging, CTC status identifies high‐risk patients with poorer survival—offering a simple, minimally invasive tool ...
Susanne Flach, Gizem Abaci, Tom Huberty, Axel Lechner, Lukas Käsmann, Jens Ricke, Sophia Stöcklein, Martin Canis, Philipp Baumeister, Marianna Alunni‐Fabbroni   +9 more
wiley   +1 more source

Single‐cell DNA methylation profiling: Technologies, computation, and applications in precision oncology

Molecular Oncology, EarlyView.
Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley   +1 more source

Reliability-Based Topology Optimization with a Proportional Topology for Reliability

Aerospace
This research proposes an efficient technique for reliability-based topology optimization (RBTO), which deals with uncertainty and employs proportional topology optimization (PTO) to achieve the optimal reliability structure. The recent technique, called
Noppawit Kumkam, Suwin Sleesongsom
doaj   +1 more source

Reliability‐based layout optimization in offshore wind energy systems

Wind Energy, 2022
Existing methods for optimizing wind array layouts typically use power or cost objectives and rarely consider reliability‐based objectives. Component and system failure rates, however, are dependent on location‐specific wind conditions, are influenced by
Caitlyn E. Clark, Garrett Barter, Kelsey Shaler, Bryony DuPont   +3 more
doaj   +1 more source

Mechanisms and therapeutic opportunities of the ribotoxic stress response in cancer

Molecular Oncology, EarlyView.
Cancer cells' high translational demand creates opportunities to therapeutically target ribosome function. Ribosome stalling and collisions activate ZAKα and the ribotoxic stress response (RSR), which can trigger rapid, p53‐independent apoptosis in cancer.
Anastassiya Kim, Maryam Aslam, Elouise Torruella, Alphons Sony, Asif Rahman, Simira Smith, Columba de la Parra, Moira Sauane   +7 more
wiley   +1 more source

Reliability and fault tolerance modelling of multiprocessor systems [PDF]

, 1989
This thesis was submitted for the degree of Doctor of Philosophy and awarded by Brunel University.Reliability evaluation by analytic modelling constitute an important issue of designing a reliable multiprocessor system.
Valdivia, Roberto Abraham
core   +6 more sources

Profiling neoadjuvant therapy response in rectal cancer using meta‐analysis of publicly available transcriptomic RNA‐seq datasets

Molecular Oncology, EarlyView.
This study integrates publicly available transcriptomic datasets to identify molecular signatures associated with response to neoadjuvant chemoradiotherapy in locally advanced rectal cancer. By analyzing a combination of multiple cohorts with bioinformatics approaches, we reveal biological pathways and immune‐related features that may improve ...
Aleksandra Stanojevic, Rafael Stroggilos, Mladen Marinkovic, Ana Djuric, Suzana Stojanovic‐Rundic, Radmila Jankovic, Sergi Castellvi‐Bel, Remond J.A. Fijneman, Antonia Vlahou, Jerome Zoidakis, Milena Cavic   +10 more
wiley   +1 more source

Reliability-based design optimization of ship structure using SMOTE algorithm and dynamic surrogate model

Zhongguo Jianchuan Yanjiu, 2020
Objectives Aiming at the problem that it is difficult to ensure global approximation accuracy and computational efficiency in the traditional reliability-based design optimization of ship structures, a reliability optimization strategy based on a dynamic
LIU Jing, WANG Deyu
doaj   +1 more source

Extracellular matrix remodeling and immune reprogramming drive residual tumor progression of liver cancer after incomplete microwave ablation

Molecular Oncology, EarlyView.
Incomplete microwave ablation (iMWA) of liver cancer triggers a biphasic progression in residual tumors. At Day 3, the microenvironment is characterized by acute inflammatory responses and extracellular matrix (ECM) remodeling. By Day 14, a profound shift occurs toward oncogenic signal transduction and immunosuppression, marked by macrophage ...
Yu Liu, Yubei He, Nikolaus Berndt, Michael Mülleder, Kathrin Textoris‐Taube, Jing Guo, Matthias Stechele, Justus Ramtke, Shraga Nahum Goldberg, Lynn Jeanette Savic   +9 more
wiley   +1 more source

Reliability-based structural optimization

, 2023
Presented PhD thesis deals with reliability-based optimization of structures and problems related to automatization of various algorithms of solution for various reliability-based optimization task definitions.
Slowik, Ondřej
core   +1 more source