Results 81 to 90 of about 1,254,315 (297)
Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity
Molecular Oncology, EarlyView.Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung +17 more
wiley +1 more source
Jixie qiangdu, 2021 As a kind of bionic robot fish,bionic killer whale played an important role in ocean development and scientific investigation. Based on the flapping wing movement theory,the bionic killer whale’s mechanism was analyzed,its instantaneous load was ...
LI MingHao +5 more
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The Malaysian Medication Adherence Scale (MALMAS): Concurrent Validity Using a Clinical Measure among People with Type 2 Diabetes in Malaysia. [PDF]
, 2015 Medication non-adherence is a prevalent problem worldwide but up to today, no gold standard is available to assess such behavior. This study was to evaluate the psychometric properties, particularly the concurrent validity of the English version of the ...
Chua, Siew Siang +3 more
core +2 more sources
Molecular Oncology, EarlyView.This study shows that copy number variations (CNVs) can be reliably detected in formalin‐fixed paraffin‐embedded (FFPE) solid cancer samples using ultra‐low‐pass whole‐genome sequencing, provided that key (pre)‐analytical parameters are optimized.
Hanne Goris +10 more
wiley +1 more source
Molecular Oncology, EarlyView.Single circulating tumor cells (sCTCs) from high‐grade serous ovarian cancer patients were enriched, imaged, and genomically profiled using WGA and NGS at different time points during treatment. sCTCs revealed enrichment of alterations in Chromosomes 2, 7, and 12 as well as persistent or emerging oncogenic CNAs, supporting sCTC identity.
Carolin Salmon +9 more
wiley +1 more source
Reliability sensitivity analysis using axis orthogonal importance Latin hypercube sampling method
Advances in Mechanical Engineering, 2019 In this article, a combined use of Latin hypercube sampling and axis orthogonal importance sampling, as an efficient and applicable tool for reliability analysis with limited number of samples, is explored for sensitivity estimation of the failure ...
Wei Zhao, YangYang Chen, Jike Liu
doaj +1 more source
Molecular Oncology, EarlyView.Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat +8 more
wiley +1 more source
RELIABILITY SENSITIVITY ANALYSIS OF THE DRIVE SHAFT AND OPTIMIZE BASED ON FOUTTH-MOMENT TECHNIQUE
Jixie qiangdu, 2017 Numerical method for reliability sensitivity design is presented based on fourth moment technique,track-laying vehicle drive shaft mechanical model is set to discuss and analyze only know the mechanical components under random distribution parameters ...
LIU Zhe, TAO FengHe, JIA ChangZhi
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Molecular Oncology, EarlyView.Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley +5 more
wiley +1 more source
Advances in Mechanical Engineering, 2014 There are usually several potential failure modes in mechanical components. The conventional model for the system analysis is built under the condition that all failure modes are independent of each other.
Hao Lu, Yonghui He, Yimin Zhang
doaj +1 more source