Results 61 to 70 of about 2,821,697 (256)

Epigenetic reprogramming of lineage switching in cancer

FEBS Letters, EarlyView.
Cancer cells rarely commit to a single identity. Epigenetic mechanisms and tumor microenvironment cues push epithelial cells toward flexible, hybrid states that can shift into mesenchymal, neuroendocrine, or stem‐like fates, driving metastasis, drug resistance, and tumor heterogeneity. Targeting the epigenetic regulators behind these transitions, using
Ezgi Boyvatlı, Burcu Akman, Ezgi Bağırsakçı, Nese Atabey, Serap Erkek‐Ozhan   +4 more
wiley   +1 more source

Wideband Circularly Polarized Cross-Dipole Antenna With Parasitic Elements

IEEE Access, 2019
A wideband circularly polarized (CP) cross-dipole antenna with parasitic elements is proposed. The proposed antenna consists of a pair of driven crossed strip dipoles, two kinds of parasitic elements (inner and outer parasitic elements), and a pair of ...
Lei Wang, Wen-Xiao Fang, Yun-Fei En, Yun Huang, Wei-Heng Shao, Bin Yao   +5 more
doaj   +1 more source

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source

Structural and biochemical analysis of a B12 superbinder

FEBS Letters, EarlyView.
BtuG proteins are vitamin B12 scavengers in Bacteroides thetaiotaomicron, a dominant human gut bacterium. We present crystal structures of three BtuG homologs bound to cobalamin and its precursor cobinamide, revealing picomolar binding affinities, among the highest known for any natural protein.
Jose M. Martinez Felices, Jacob J. Whittaker, Dirk J. Slotboom, Albert Guskov   +3 more
wiley   +1 more source

A GO-FLOW and Dynamic Bayesian Network Combination Approach for Reliability Evaluation With Uncertainty: A Case Study on a Nuclear Power Plant

IEEE Access, 2018
Uncertainty analyses have been considered critical analysis methods for identifying the risks in reliability evaluations. However, with multi-phase, multi-state, and repairable features, this method cannot effectively and precisely display the ...
Yi Ren, Dongming Fan, Xinrui Ma, Zili Wang, Qiang Feng, Dezhen Yang   +5 more
doaj   +1 more source

The Shewanella oneidensis Fic enzyme SoFic targets the switch‐I region of EF‐Tu for AMPylation

FEBS Letters, EarlyView.
Fic enzymes mediate diverse post‐translational modifications across all domains of life, including AMPylation. Prokaryotic EF‐Tu can be AMPylated and deAMPylated by the conserved Fic enzyme SoFic. Structural and biochemical approaches were used to characterize the effect of AMPylation on EF‐Tu, SoFic's enzymatic activities, and the enzyme‐target ...
Svenja Runge, Vivian Pogenberg, Alexander Baumgart, Bente Siebels, Hartmut Schlüter, Michael Hecht‐Bucher, Aymelt Itzen   +6 more
wiley   +1 more source

Sensitivity Analysis for a Scenario-Based Reliability Prediction Model [PDF]

, 2005
As a popular means for capturing behavioural requirements, scenariosshow how components interact to provide system-level functionality.If component reliability information is available, scenarioscan be used to perform early system reliability assessment.
David S. Rosenblum, Genaína N. Rodrigues, Uchitel, S, Rodrigues, G, Sebastian Uchitel, Rosenblum, D   +5 more
core   +1 more source

Modelling and managing reliability growth during the engineering design process [PDF]

, 2010
[This is a keynote speech presented at the 2nd International Conference on Design Engineering and Science, discussing modelling and managing reliability growth during the engineering process.] Reliability is vital for safe and efficient operation of ...
Quigley, J.L., Walls, Lesley
core   +3 more sources

General Stress-Strength Interference and Gamma Process Combined Method for Space Solar Cell Components Reliability Analysis

IEEE Access, 2019
Space solar cell components always suffered from the complex and hostile space environment. The reliability of space solar cell components is important to ensure the mission success of space satellites.
Bo Sun, Yu Li, Zili Wang, Yi Ren, Qiang Feng, Dezhen Yang, Haifu Jiang   +6 more
doaj   +1 more source

Chiral separation of chloroalkanes with the chromatographic column onboard Martian rovers

FEBS Letters, EarlyView.
Computer image of the Rosalind Franklin Rover of ESA's ExoMars mission. ExoMars is scheduled to land on planet Mars in Oxia Planum in 2029. This area represents an interesting spot to look for biosignatures. Investigations of ExoMars include measurement on molecular chirality. We show that chiral chloroalkanes, that have been identified on Mars, can be
Asma Merzougui, Agnes Banreti, Armelle L. Ernst, Guillaume Leseigneur, Uwe J. Meierhenrich   +4 more
wiley   +1 more source