Results 101 to 110 of about 4,030,856 (299)
Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma
Molecular Oncology, EarlyView.The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic +5 more
wiley +1 more source
Molecular Oncology, EarlyView.We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric +10 more
wiley +1 more source
Dynamic Response and Reliability Assessment of Power Transmission Towers Under Wind-Blown Sand Loads
EnergiesThe global transition toward clean energy has driven the extensive deployment of overhead tower-lines in desserts, where such structures face unique challenges from wind–sand interactions.
Jun Lu +5 more
doaj +1 more source
Molecular Oncology, EarlyView.Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova +14 more
wiley +1 more source
Frontiers in Public HealthPurposeAs a globally popular physical activity, swimming also presents challenges due to its inherent aquatic risks. Therefore, the cultivation of swimming competence emerges as a crucial strategy in preventing drowning incidents.
Miao Zhao +4 more
doaj +1 more source
Molecular Oncology, EarlyView.In the present work, we have identified a transcriptional signature based on the differential expression of six genes (BCL2&MAST4, HSH2D&LAT2, METRN&PITPNM2) that would facilitate the early detection of T‐cell acute lymphoblastic leukemia (T‐ALL) patients prone to a poor treatment response and could be implemented at diagnosis, along with other risk ...
Antonio Lahera +11 more
wiley +1 more source
Reliability computation using fault tree analysis [PDF]
A method is presented for calculating event probabilities from an arbitrary fault tree. The method includes an analytical derivation of the system equation and is not a simulation program. The method can handle systems that incorporate standby redundancy
Chelson, P. O.
core +1 more source
Molecular Oncology, EarlyView.We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu +10 more
wiley +1 more source
Reliability Analysis of CVT Online Monitoring Device Based on Bayesian Network
EnergiesTo address the challenges of equipment reliability assessment in the context of intelligent power systems, especially the shortcomings of traditional methods in dealing with multi-factor coupling and uncertain fault inference of CVT (capacitive voltage ...
Xu Chen +7 more
doaj +1 more source
Reliability based analysis of contact problems [PDF]
The Batdorf model is modified to include the reduction in shear due to the effect of compressive stresses on the crack face. This new formulation was used to obtain the probability of failure of ceramic components under contact stress conditions.
Ghosn, Louis J., Powers, Lynn M.
core +1 more source