Results 111 to 120 of about 28,090,256 (352)
Molecular Oncology, EarlyView.The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington +10 more
wiley +1 more source
, 2007 Traditional reliability analysis uses probability distributions to calculate reliability. In many engineering applications, some nondeterministic variables are known within intervals.
Du, Xiaoping
core
Molecular Oncology, EarlyView.Detecting circulating tumor cells (CTCs) in blood before surgery may help predict outcomes in patients with head and neck squamous cell carcinoma (HNSCC). Here, we show when combined with tumor size and lymph node involvement from routine imaging, CTC status identifies high‐risk patients with poorer survival—offering a simple, minimally invasive tool ...
Susanne Flach +9 more
wiley +1 more source
Molecular Oncology, EarlyView.Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley +1 more source
Damage of additively manufactured polymer materials: experimental and probabilistic analysis
Fracture and Structural IntegrityThis paper presents a study on the tensile, fracture, damage, and reliability properties of 3D printed polylactic acid (PLA), based on a series of experiments. The study focuses on polylactic acid (PLA) samples produced using fused filament manufacturing
Hachimi Taoufik +2 more
doaj +1 more source
Molecular Oncology, EarlyView.Interferon type 1 (IFN‐1) production and signaling is associated with the acquisition of therapy resistance, following chronic DNA damage, via Interferon‐related DNA damage resistance signature (IRDS) gene expression. An alternative, DNA damage‐independent role of sustained IFN‐1 mediated resistance was identified and characterized by the emergence of ...
Ashlyn Conant +11 more
wiley +1 more source
Aviation gas turbines are critical components in the aerospace industry, where reliability directly influences maintenance costs, operational efficiency, and safety.
Cui, Bo
core
Reliability analysis of engineering structures
, 2021 Reliability analysis is becoming more prevalent in modern engineering. With wider access to finite element method (FEM), reliability analysis provides a new avenue for engineering. The ability to make pre-informed forecasts on probability of failure with
Hon, Justin Ta Hao
core
CEACAM1 participation in breast cancer progression
Molecular Oncology, EarlyView.In invasive breast cancer (BC), CEACAM1 shifts from an apical to a uniform membranous/cytoplasmic pattern, or is lost, as tumors dedifferentiate, inversely tracking the Ki‐67 proliferative index. In MCF‐7 cells, only CEACAM1‐4L suppresses proliferation, repressing cell cycle and growth factor genes.
Mykola Lyndin +3 more
wiley +1 more source
Dynamic Response and Reliability Assessment of Power Transmission Towers Under Wind-Blown Sand Loads
EnergiesThe global transition toward clean energy has driven the extensive deployment of overhead tower-lines in desserts, where such structures face unique challenges from wind–sand interactions.
Jun Lu +5 more
doaj +1 more source