Results 91 to 100 of about 24,260,019 (288)

Stability of heterogeneous linear and nonlinear car-following models

Franklin Open
Stop-and-go waves in congested road traffic are complex collective phenomena with significant implications for traffic engineering, road safety and the environment.
Matthias Ehrhardt, Antoine Tordeux
doaj   +1 more source

Inhibition of cyclin‐dependent kinases 12/13 using CT7439 as a treatment for colorectal cancer with CDK12 upregulation

Molecular Oncology, EarlyView.
The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington, Divya L. Dayanidhi, Mohammad Zokaasadi, John B. Mantyh, Pelumi D. Olawuni, Gabrielle Rupprecht, Jeremy M. Force, Shannon McCall, Ashwani K. Bahl, David S. Hsu, Jason A. Somarelli   +10 more
wiley   +1 more source

System reliability analysis of structures subjected to fatigue induced sequential failures using evolutionary algorithms [PDF]

, 2010
In the past, many catastrophic failures have occurred due to lack of redundancy and managerial oversight. For example, it was found that local failures due to improper welds that connected the suspended truss to the anchor trusses caused the collapse of ...
Kurtz, Nolan S.
core  

A tracing-based realistic state space selection method for composite power system reliability assessment in the restructured scenario

, 2008
Electric power industry deregulation has brought about the unbundling of generation, transmission and distribution services and as such, new techniques for reliability assessment are being developed to account for the consequent structural changes in the
A. K. Verma, VENU, VIJAY, V. Vijay Venu, VERMA, AK   +3 more
core   +1 more source

Preoperative circulating tumor cells integrated with imaging analysis for prognostic evaluation in head and neck squamous cell carcinoma

Molecular Oncology, EarlyView.
Detecting circulating tumor cells (CTCs) in blood before surgery may help predict outcomes in patients with head and neck squamous cell carcinoma (HNSCC). Here, we show when combined with tumor size and lymph node involvement from routine imaging, CTC status identifies high‐risk patients with poorer survival—offering a simple, minimally invasive tool ...
Susanne Flach, Gizem Abaci, Tom Huberty, Axel Lechner, Lukas Käsmann, Jens Ricke, Sophia Stöcklein, Martin Canis, Philipp Baumeister, Marianna Alunni‐Fabbroni   +9 more
wiley   +1 more source

Implementation of risk and reliability analysis techniques in ICT

, 2009
Many industry sectors look back on a downright success story in development and implementing risk and reliability analysis methods. However the application of these methods seems to be questionable to enterprises in the area of information and ...
Kollmann, Eva, Mock, Ralf Günter, Bünzli, Ernst   +2 more
core   +2 more sources

CEACAM1 participation in breast cancer progression

Molecular Oncology, EarlyView.
In invasive breast cancer (BC), CEACAM1 shifts from an apical to a uniform membranous/cytoplasmic pattern, or is lost, as tumors dedifferentiate, inversely tracking the Ki‐67 proliferative index. In MCF‐7 cells, only CEACAM1‐4L suppresses proliferation, repressing cell cycle and growth factor genes.
Mykola Lyndin, Irina Kube‐Golovin, Anatolii Romaniuk, Gunther Wennemuth   +3 more
wiley   +1 more source

An explorative application of the task reliability index framework for human reliability data collection

To enhance the empirical basis of probability estimates of human failure events in human reliability analysis, a framework for data collection and analysis has recently been proposed based on a task reliability index (TRI).
Kim, Yochan (author), Dang, Vinh N. (author), Podofillini, Luca (author)   +2 more
core   +1 more source

Damage of additively manufactured polymer materials: experimental and probabilistic analysis

Fracture and Structural Integrity
This paper presents a study on the tensile, fracture, damage, and reliability properties of 3D printed polylactic acid (PLA), based on a series of experiments. The study focuses on polylactic acid (PLA) samples produced using fused filament manufacturing
Hachimi Taoufik, Ait Hmazi Fouad, Majid Fatima   +2 more
doaj   +1 more source

Intrapatient tumour heterogeneity and clonal evolution in an autopsy study of metastatic salivary gland cancer

Molecular Oncology, EarlyView.
Tumour heterogeneity and clonal evolution of metastatic salivary gland cancer were evaluated in two patients with adenoid carcinoma and one patient with myoepithelial carcinoma. Radiology‐guided autopsy enabled multi‐region sampling (total samples n = 149), followed by whole‐genome sequencing and phylogenetic reconstruction (17 tumour samples, 4–7 per ...
Gerben Lassche, Niels J. van Ruitenbeek, Charlotte Adang, Luke O'Gorman, Pui Yuen Lee, Willemijn M. Klein, Adriana C. H. van Engen‐van Grunsven, Jack A. Schalken, Sander Bervoets, Gerald W. Verhaegh, Carla M. L. van Herpen   +10 more
wiley   +1 more source