Results 91 to 100 of about 1,305,501 (258)

Dynamic Response and Reliability Assessment of Power Transmission Towers Under Wind-Blown Sand Loads

Energies
The global transition toward clean energy has driven the extensive deployment of overhead tower-lines in desserts, where such structures face unique challenges from wind–sand interactions.
Jun Lu, Jin Li, Xiaoqian Ma, Weiguang Tian, Linfeng Zhang, Peng Zhang   +5 more
doaj   +1 more source

Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics

FEBS Letters, EarlyView.
Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt, Ana‐Maria Sandru, Georg Vucak, Sebastian Didusch, Biljana Riemelmoser, Karin Ehrenreiter, Markus Hartl, Lukas A. Huber, Manuela Baccarini   +8 more
wiley   +1 more source

Exploring the structural validity and reliability of the swimming competence assessment scale in college students

Frontiers in Public Health
PurposeAs a globally popular physical activity, swimming also presents challenges due to its inherent aquatic risks. Therefore, the cultivation of swimming competence emerges as a crucial strategy in preventing drowning incidents.
Miao Zhao, Cheng Chen, Peng Ning, Bo Wei Zhang, Yupeng Shen   +4 more
doaj   +1 more source

Epigenetic reprogramming of lineage switching in cancer

FEBS Letters, EarlyView.
Cancer cells rarely commit to a single identity. Epigenetic mechanisms and tumor microenvironment cues push epithelial cells toward flexible, hybrid states that can shift into mesenchymal, neuroendocrine, or stem‐like fates, driving metastasis, drug resistance, and tumor heterogeneity. Targeting the epigenetic regulators behind these transitions, using
Ezgi Boyvatlı, Burcu Akman, Ezgi Bağırsakçı, Nese Atabey, Serap Erkek‐Ozhan   +4 more
wiley   +1 more source

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source

Reliability Analysis of CVT Online Monitoring Device Based on Bayesian Network

Energies
To address the challenges of equipment reliability assessment in the context of intelligent power systems, especially the shortcomings of traditional methods in dealing with multi-factor coupling and uncertain fault inference of CVT (capacitive voltage ...
Xu Chen, Haomiao Zhang, Chao Zhang, Yinzhe Xu, Yu Yan, Yuntao Zhao, Xuhui Chen, Rui Ren   +7 more
doaj   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Lubrication Reliability and Evolution Laws of Gear Transmission Considering Uncertainty Parameters

Lubricants
To address the challenge of predicting lubrication states and reliability caused by the uncertainty of gear materials and structural parameters, a lubrication reliability analysis method considering the randomness of gear parameters is proposed. Firstly,
Jiaxing Pei, Yuanyuan Tian, Hongjuan Hou, Yourui Tao, Miaojie Wu, Leilei Wang   +5 more
doaj   +1 more source

Differential expression of cancer‐related genes supports prediction of poor response to first‐line treatments in T‐ALL pediatric patients with high minimal residual disease

Molecular Oncology, EarlyView.
In the present work, we have identified a transcriptional signature based on the differential expression of six genes (BCL2&MAST4, HSH2D&LAT2, METRN&PITPNM2) that would facilitate the early detection of T‐cell acute lymphoblastic leukemia (T‐ALL) patients prone to a poor treatment response and could be implemented at diagnosis, along with other risk ...
Antonio Lahera, Laura Vela‐Martín, Pablo Fernández‐Navarro, José Luis López‐Lorenzo, Javier Cornago, Pilar Llamas, Eduardo Pérez‐Gómez, José Luis Marín‐Rubio, Manuel Fresno, Javier Santos, José Fernández‐Piqueras, María Villa‐Morales   +11 more
wiley   +1 more source

Graph Neural Networks for Evaluating the Reliability and Resilience of Infrastructure Systems: A Systematic Review of Models, Applications, and Future Directions

IEEE Access
Interdependent infrastructure systems serve as the foundation of modern society, ensuring the delivery of essential services, economic stability, and public well-being. The increasing integration of these systems, driven by advancements in cyber-physical
Tong Liu, Fangyu Liu
doaj   +1 more source