Results 111 to 120 of about 27,916,807 (331)
ATF4‐mediated stress response as a therapeutic vulnerability in chordoma
Molecular Oncology, EarlyView.We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone +11 more
wiley +1 more source
Dynamic Response and Reliability Assessment of Power Transmission Towers Under Wind-Blown Sand Loads
EnergiesThe global transition toward clean energy has driven the extensive deployment of overhead tower-lines in desserts, where such structures face unique challenges from wind–sand interactions.
Jun Lu +5 more
doaj +1 more source
Sensitivity analysis of the CREAM method for Human Reliability [PDF]
, 2008 This paper reports a sensitivity analysis of the CREAM HRA method. We consider three different aspects: the difference between the outputs of the Basic and Extended methods, on the same HRA scenario; the variability in outputs through the choices made ...
Bayley, Clare, Bedford, T.J.
core
Molecular Oncology, EarlyView.The cancer problem is increasing globally with projections up to the year 2050 showing unfavourable outcomes in terms of incidence and cancer‐related deaths. The main challenges are prevention, improved therapeutics resulting in increased cure rates and enhanced health‐related quality of life.
Ulrik Ringborg +43 more
wiley +1 more source
Frontiers in Public HealthPurposeAs a globally popular physical activity, swimming also presents challenges due to its inherent aquatic risks. Therefore, the cultivation of swimming competence emerges as a crucial strategy in preventing drowning incidents.
Miao Zhao +4 more
doaj +1 more source
LDAcoop: Integrating non‐linear population dynamics into the analysis of clonogenic growth in vitro
Molecular Oncology, EarlyView.Limiting dilution assays (LDAs) quantify clonogenic growth by seeding serial dilutions of cells and scoring wells for colony formation. The fraction of negative wells is plotted against cells seeded and analyzed using the non‐linear modeling of LDAcoop.
Nikko Brix +13 more
wiley +1 more source
Molecular Oncology, EarlyView.Nanosecond infrared laser (NIRL) low‐volume sampling combined with shotgun lipidomics uncovers distinct lipidome alterations in oropharyngeal squamous cell carcinoma (OPSCC) of the palatine tonsil. Several lipid species consistently differentiate tumor from healthy tissue, highlighting their potential as diagnostic markers.
Leonard Kerkhoff +11 more
wiley +1 more source
Reliability Analysis of CVT Online Monitoring Device Based on Bayesian Network
EnergiesTo address the challenges of equipment reliability assessment in the context of intelligent power systems, especially the shortcomings of traditional methods in dealing with multi-factor coupling and uncertain fault inference of CVT (capacitive voltage ...
Xu Chen +7 more
doaj +1 more source
Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity
Molecular Oncology, EarlyView.Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung +17 more
wiley +1 more source
Lubrication Reliability and Evolution Laws of Gear Transmission Considering Uncertainty Parameters
LubricantsTo address the challenge of predicting lubrication states and reliability caused by the uncertainty of gear materials and structural parameters, a lubrication reliability analysis method considering the randomness of gear parameters is proposed. Firstly,
Jiaxing Pei +5 more
doaj +1 more source