Results 71 to 80 of about 5,990,608 (288)

A GO-FLOW and Dynamic Bayesian Network Combination Approach for Reliability Evaluation With Uncertainty: A Case Study on a Nuclear Power Plant

open access: yesIEEE Access, 2018
Uncertainty analyses have been considered critical analysis methods for identifying the risks in reliability evaluations. However, with multi-phase, multi-state, and repairable features, this method cannot effectively and precisely display the ...
Yi Ren   +5 more
doaj   +1 more source

Flow Enabled Target Capture Halbach‐based magnetic enrichment increases circulating tumor cell capture from blood in metastatic cancer patients

open access: yesMolecular Oncology, EarlyView.
Pair‐wise comparison of the CellSearch and FETCH enrichment technologies for circulating tumor cells (CTCs) from metastatic breast, prostate, and small cell lung cancer patients shows an increased capture of CTCs using FETCH enrichment. The clinical implementation of circulating tumor cells (CTCs) as a predictive tool for therapy efficacy in the ...
Michiel Stevens   +6 more
wiley   +1 more source

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

open access: yesMolecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim   +3 more
wiley   +1 more source

A Data-Driven Approach to Aircraft Engine MRO Using Enhanced ANNs Based on FMECA

open access: yesIEEE Access
Aircraft engine MRO is essential for safe, reliable, and cost-effective aviation operations. Traditional maintenance methods, such as scheduled and condition-based maintenance, often result in excessive downtime, higher costs, and inefficient resource ...
Idriss Dagal   +5 more
doaj   +1 more source

Reliability of Emergent Intelligence in Unmanned Swarms: Technical Challenges and Future Development [PDF]

open access: yes中国工程科学
As a core frontier of next-generation artificial intelligence, emergent intelligence in unmanned swarms achieves efficient collaboration and intelligent enhancement through biomimetic self-organization and local interactions, demonstrating significant ...
Yue Zhang   +6 more
doaj   +1 more source

Inhibition of cyclin‐dependent kinases 12/13 using CT7439 as a treatment for colorectal cancer with CDK12 upregulation

open access: yesMolecular Oncology, EarlyView.
The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington   +10 more
wiley   +1 more source

Reliability prediction in model driven development [PDF]

open access: yes, 2005
Evaluating the implications of an architecture design early in the software development lifecycle is important in order to reduce costs of development.
David S. Rosenblum   +6 more
core   +1 more source

Preoperative circulating tumor cells integrated with imaging analysis for prognostic evaluation in head and neck squamous cell carcinoma

open access: yesMolecular Oncology, EarlyView.
Detecting circulating tumor cells (CTCs) in blood before surgery may help predict outcomes in patients with head and neck squamous cell carcinoma (HNSCC). Here, we show when combined with tumor size and lymph node involvement from routine imaging, CTC status identifies high‐risk patients with poorer survival—offering a simple, minimally invasive tool ...
Susanne Flach   +9 more
wiley   +1 more source

Single‐cell DNA methylation profiling: Technologies, computation, and applications in precision oncology

open access: yesMolecular Oncology, EarlyView.
Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley   +1 more source

Analysis of University Students’ Behavior Based on a Fusion K-Means Clustering Algorithm

open access: yesApplied Sciences, 2020
With the development of big data technology, creating the ‘Digital Campus’ is a hot issue. For an increasing amount of data, traditional data mining algorithms are not suitable. The clustering algorithm is becoming more and more important in the field of
Wenbing Chang   +6 more
doaj   +1 more source

Home - About - Disclaimer - Privacy