Results 81 to 90 of about 5,990,608 (288)

CEACAM1 participation in breast cancer progression

Molecular Oncology, EarlyView.
In invasive breast cancer (BC), CEACAM1 shifts from an apical to a uniform membranous/cytoplasmic pattern, or is lost, as tumors dedifferentiate, inversely tracking the Ki‐67 proliferative index. In MCF‐7 cells, only CEACAM1‐4L suppresses proliferation, repressing cell cycle and growth factor genes.
Mykola Lyndin, Irina Kube‐Golovin, Anatolii Romaniuk, Gunther Wennemuth   +3 more
wiley   +1 more source

Intrapatient tumour heterogeneity and clonal evolution in an autopsy study of metastatic salivary gland cancer

Molecular Oncology, EarlyView.
Tumour heterogeneity and clonal evolution of metastatic salivary gland cancer were evaluated in two patients with adenoid carcinoma and one patient with myoepithelial carcinoma. Radiology‐guided autopsy enabled multi‐region sampling (total samples n = 149), followed by whole‐genome sequencing and phylogenetic reconstruction (17 tumour samples, 4–7 per ...
Gerben Lassche, Niels J. van Ruitenbeek, Charlotte Adang, Luke O'Gorman, Pui Yuen Lee, Willemijn M. Klein, Adriana C. H. van Engen‐van Grunsven, Jack A. Schalken, Sander Bervoets, Gerald W. Verhaegh, Carla M. L. van Herpen   +10 more
wiley   +1 more source

High-resolution X-ray imaging for industrial process monitoring and quality control

Компьютерная оптика
High-resolution X-ray imaging is an essential component of advanced workflows for industrial process monitoring and quality control (e.g., for metrology and defect inspection in the semiconductor industry).
E. Zschech, M.V. Chukalina, K.B. Bulatov
doaj   +1 more source

ADP‐ribosylation: An emerging regulator of the epigenome

Molecular Oncology, EarlyView.
ADP‐ribosylation has emerged as a dynamic epigenetic signaling mechanism that modifies histones and chromatin‐associated proteins. Through coordinated PARylation and MARylation, it integrates with other histone modifications to regulate chromatin structure, transcription factor activity, and gene expression, influencing genome function and disease ...
Cristel V. Camacho, Chenqian Liu, W. Lee Kraus   +2 more
wiley   +1 more source

The Evolving Paradigm of Reliability Engineering for Complex Systems: A Review from an Uncertainty Control Perspective

Aerospace
Traditional reliability engineering paradigms, originally designed to prevent physical component failures, are facing a fundamental crisis when applied to today’s software-intensive and autonomous systems.
Zhaoyang Zeng, Cong Lin, Wensheng Peng, Ming Xu   +3 more
doaj   +1 more source

Mechanisms and therapeutic opportunities of the ribotoxic stress response in cancer

Molecular Oncology, EarlyView.
Cancer cells' high translational demand creates opportunities to therapeutically target ribosome function. Ribosome stalling and collisions activate ZAKα and the ribotoxic stress response (RSR), which can trigger rapid, p53‐independent apoptosis in cancer.
Anastassiya Kim, Maryam Aslam, Elouise Torruella, Alphons Sony, Asif Rahman, Simira Smith, Columba de la Parra, Moira Sauane   +7 more
wiley   +1 more source

Robust electromigration reliability through engineering optimization

, 2014
With complex process integration approach and severe fabrication limitations caused by introduction of new materials and diminishing process margins, there are mounting concerns with the increased failure rate at the early life cycle (e.g.
Tee, Kheng Chok, Pey, Kin Leong, Ng, Wee Loon, Aubel, Oliver, Liu, Junfeng, Ee, Yong Chiang, Tan, Chuan Seng   +6 more
core   +1 more source

Assessing the Reliability of Wind-Powered EV Charging Systems in Poland Based on Long-Term Wind Data

Applied Sciences
The operational reliability of wind-powered electric vehicle charging systems (WPECS) depends not only on average wind resources but also on their temporal variability and continuity.
Magdalena Zimakowska-Laskowska, Olga Orynycz, Piotr Laskowski, Andrzej Świderski, Kamil Urbanowicz, Andrzej Wasiak, Adam Deptuła   +6 more
doaj   +1 more source

Profiling neoadjuvant therapy response in rectal cancer using meta‐analysis of publicly available transcriptomic RNA‐seq datasets

Molecular Oncology, EarlyView.
This study integrates publicly available transcriptomic datasets to identify molecular signatures associated with response to neoadjuvant chemoradiotherapy in locally advanced rectal cancer. By analyzing a combination of multiple cohorts with bioinformatics approaches, we reveal biological pathways and immune‐related features that may improve ...
Aleksandra Stanojevic, Rafael Stroggilos, Mladen Marinkovic, Ana Djuric, Suzana Stojanovic‐Rundic, Radmila Jankovic, Sergi Castellvi‐Bel, Remond J.A. Fijneman, Antonia Vlahou, Jerome Zoidakis, Milena Cavic   +10 more
wiley   +1 more source

Validating task analysis for error identification: Reliability and validity of a human error prediction technique [PDF]

, 2005
This paper reports on the theoretical and empirical developments for an error prediction methodology called task analysis for error identification (TAFEI). Other researchers have noted the need for theoretically driven approaches that are able to provide
Baber, Christopher, Stanton, Neville A., Stanton, NA, Baber, C, Baber, Christopher; id_orcid   +4 more
core   +1 more source