Results 71 to 80 of about 5,372,645 (294)

Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics

open access: yesFEBS Letters, EarlyView.
Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt   +8 more
wiley   +1 more source

Shape optimization of compressed rods considering material and geometric uncertainty: an analytical – stochastic approach

open access: yesInternational Journal of Applied Mechanics and Engineering
The article presents a stochastic approach to the shape optimization of compressed rods, taking into account random deviations of Young’s modulus and the second moment of area.
Mirosław Sadowski
doaj   +1 more source

The Reliability of Countermovement Jump Performance and the Reactive Strength Index in Identifying Drop-Jump Drop Height in Hurling Players [PDF]

open access: yes, 2017
The purpose of this study was to estimate the inter-day reliability of countermovement jump performance (CMJ) and the reactive strength index (RSI) in identifying drop-jump drop height in male hurling players.
Cooper, Stephen-Mark   +3 more
core  

Epigenetic reprogramming of lineage switching in cancer

open access: yesFEBS Letters, EarlyView.
Cancer cells rarely commit to a single identity. Epigenetic mechanisms and tumor microenvironment cues push epithelial cells toward flexible, hybrid states that can shift into mesenchymal, neuroendocrine, or stem‐like fates, driving metastasis, drug resistance, and tumor heterogeneity. Targeting the epigenetic regulators behind these transitions, using
Ezgi Boyvatlı   +4 more
wiley   +1 more source

Indicators of reliability of heat supply organizations

open access: yesИзвестия высших учебных заведений: Проблемы энергетики, 2017
One of the key indicators of heat supply organizations is the reliability of energy facilities. The index of reliability of heat supply organization is of interest to potential investors, to assess the risks of investing projects.
I. G. Akhmetova
doaj   +1 more source

Index 1985 [PDF]

open access: yes, 1985
This is the 1985 edition of the Index. The Index is written by student editors, and it is the college’s yearbook. It includes an annual record of events at Wooster. This specific Index is divided into different sections including college life, activities,
Editors, Index, Index Editors,
core  

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

open access: yesFEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee   +2 more
wiley   +1 more source

Probabilistic Assessment of Soil Shear Strength Parameters Using Triaxial Test Results

open access: yesThe Baltic Journal of Road and Bridge Engineering, 2007
According to the currently valid standards, bearing resistance can be calculated applying direct informationalstatistic method which includes probabilistic models of margin of resistance Z = R – E.
Jonas Amšiejus, Neringa Dirgėlienė
doaj  

A Method for Determining the Soil Shear Strength by Eliminating the Heteroscedasticity and Correlation of the Regression Residual

open access: yesApplied Sciences
Due to cost and variability of geotechnical test results, the number of samples for geotechnical material parameters in one engineering project is limited, resulting in a certain degree of errors in the calculation of probability distribution, mean, and ...
Heng Chi   +3 more
doaj   +1 more source

Chiral separation of chloroalkanes with the chromatographic column onboard Martian rovers

open access: yesFEBS Letters, EarlyView.
Computer image of the Rosalind Franklin Rover of ESA's ExoMars mission. ExoMars is scheduled to land on planet Mars in Oxia Planum in 2029. This area represents an interesting spot to look for biosignatures. Investigations of ExoMars include measurement on molecular chirality. We show that chiral chloroalkanes, that have been identified on Mars, can be
Asma Merzougui   +4 more
wiley   +1 more source

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