Results 91 to 100 of about 5,372,645 (294)

Safety Assessment of Existing Reinforced Concrete Structures According to the Standards of the Republic of Belarus

Железобетонные конструкции
In the last decade, as part of the sustainable development strategy, more attention is paid to extending the service life of existing buildings and civil engineering structures.
D. N. Lazousky, V. V. Tur, D. O. Glukhov
doaj   +1 more source

On the Importance of Coefficient Alpha for Measurement Research: Loading Equality Is Not Necessary for Alpha's Utility as a Scale Reliability Index. [PDF]

Educ Psychol Meas, 2023
Raykov T, Anthony JC, Menold N.
europepmc   +1 more source

Use of a genetic algorithm to perform reliability analysis of unsaturated soil slopes [PDF]

, 2009
Rainfall induced landslides are a major cause of disturbance to transport networks in many parts of the world. In slopes where the water table is some depth below the ground surface, negative pore water pressure (suctions) develop in the near surface ...
Gavin, Kenneth, Xue, Jianfeng
core   +1 more source

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

Molecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim, Hwiyeong Lee, Jin Hong, Daechan Park   +3 more
wiley   +1 more source

Probabilistic slope stability analysis on marine clay seabed considering spatial variability of soil parameters

Frontiers in Built Environment
Determining the failure probabilities of submarine slopes over long distances is crucial for assessing slope stability, given the randomness of soil parameters.
Long Yu, Yang Bao, Kunming Ma, Yunrui Han, Yibin Yan, Bin Xu, Zhongtao Wang, Rui Pang   +7 more
doaj   +1 more source

VsN, a Reliability-index of Shear-wave Measurement in Sonoelastography, Is Useful for the Diagnosis of Thyroid Tumor Malignancy. [PDF]

In Vivo, 2022
Jikuzono T, Ishibashi O, Kure S, Itoh C, Yamada T, Sugitani I.   +5 more
europepmc   +1 more source

Reproducibility of functional connectivity and graph measures based on the Phase Lag Index (PLI) and weighted Phase Lag Index (wPLI) derived from high resolution EEG [PDF]

, 2014
Functional connectivity (FC) and graph measures provide powerful means to analyze complex networks. The current study determines the inter-subject-variability using the coefficient of variation (CoV) and long-term test-retest-reliability (TRT) using the ...
Florian Hatz, Christian Schindler (71594), Hardmeier, M., Cornelis Jan Stam (640429), Fuhr, Peter, Martin Hardmeier, Habib Bousleiman, Christian Schindler, Peter Fuhr, Hardmeier, Martin, Peter Fuhr (640430), Stam, C.J., Stam, Cornelis Jan, Habib Bousleiman (640428), Hatz, F., Fuhr, P., Martin Hardmeier (146865), Schindler, Christian, Cornelis Jan Stam, Schindler, C., Bousleiman, Habib, Florian Hatz (640427), Hatz, Florian, Bousleiman, H.   +23 more
core   +1 more source

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source

Inhibition of cyclin‐dependent kinases 12/13 using CT7439 as a treatment for colorectal cancer with CDK12 upregulation

Molecular Oncology, EarlyView.
The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington, Divya L. Dayanidhi, Mohammad Zokaasadi, John B. Mantyh, Pelumi D. Olawuni, Gabrielle Rupprecht, Jeremy M. Force, Shannon McCall, Ashwani K. Bahl, David S. Hsu, Jason A. Somarelli   +10 more
wiley   +1 more source

Preoperative circulating tumor cells integrated with imaging analysis for prognostic evaluation in head and neck squamous cell carcinoma

Molecular Oncology, EarlyView.
Detecting circulating tumor cells (CTCs) in blood before surgery may help predict outcomes in patients with head and neck squamous cell carcinoma (HNSCC). Here, we show when combined with tumor size and lymph node involvement from routine imaging, CTC status identifies high‐risk patients with poorer survival—offering a simple, minimally invasive tool ...
Susanne Flach, Gizem Abaci, Tom Huberty, Axel Lechner, Lukas Käsmann, Jens Ricke, Sophia Stöcklein, Martin Canis, Philipp Baumeister, Marianna Alunni‐Fabbroni   +9 more
wiley   +1 more source