Results 81 to 90 of about 604,044 (315)

Indicators of reliability of heat supply organizations

Известия высших учебных заведений: Проблемы энергетики, 2017
One of the key indicators of heat supply organizations is the reliability of energy facilities. The index of reliability of heat supply organization is of interest to potential investors, to assess the risks of investing projects.
I. G. Akhmetova
doaj   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

A Modified Reliability Index Approach for Reliability-Based Design Optimization

, 2009
RBDO problems have been intensively studied for many decades. Since Hasofer and Lind defined a measure of the second-moment reliability index, many RBDO methods utilizing the concept of reliability index have been introduced as the Reliability Index ...
Hae Chang Gea, Yogesh Jaluria, Po Ting Lin   +2 more
core   +1 more source

A Method for Determining the Soil Shear Strength by Eliminating the Heteroscedasticity and Correlation of the Regression Residual

Applied Sciences
Due to cost and variability of geotechnical test results, the number of samples for geotechnical material parameters in one engineering project is limited, resulting in a certain degree of errors in the calculation of probability distribution, mean, and ...
Heng Chi, Hengdong Wang, Yufeng Jia, Degao Zou   +3 more
doaj   +1 more source

Pre‐analytical optimization of cell‐free DNA and extracellular vesicle‐derived DNA for mutation detection in liquid biopsies

Molecular Oncology, EarlyView.
Pre‐analytical handling critically determines liquid biopsy performance. This study defines practical best‐practice conditions for cell‐free DNA (cfDNA) and extracellular vesicle–derived DNA (evDNA), showing how processing time, storage conditions, tube type, and plasma input volume affect DNA integrity and mutation detection.
Jonas Dohmen, Lucrezia De Santis, Bret M. Stephens, Vincent Bernard, Jörg C. Kalff, Lara Braun, Phillipp Leyendecker, Johannes Röttgen, Daniel Weissinger, Anirban Maitra, Paola A. Guerrero, Alexander Semaan   +11 more
wiley   +1 more source

Probabilistic Assessment of Soil Shear Strength Parameters Using Triaxial Test Results

The Baltic Journal of Road and Bridge Engineering, 2007
According to the currently valid standards, bearing resistance can be calculated applying direct informationalstatistic method which includes probabilistic models of margin of resistance Z = R – E.
Jonas Amšiejus, Neringa Dirgėlienė
doaj  

Reliability Analysis and Parameter Selection for IoT Communication Based on Deep Learning

Eng
This article first constructs a multi-layer deep learning neural network to help understand the structural characteristics of communication data, thereby learning complex functions and obtaining the predicted network values.
Bo Pang, Evgeny S. Abramov
doaj   +1 more source

EDNRB‐dependent endothelin signaling reduces proliferation and promotes proneural‐to‐mesenchymal transition in gliomas

Molecular Oncology, EarlyView.
Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau, Leonor Garcia, Hugo Arnold, Antonija Hanžek, Maialen Arrieta, Laurent R Gauthier, Christine Granotier‐Beckers, François D Boussin, Amaury Herbet, Marie Hautière, Valentin Asei‐Ceschino, Clémentin Jacques, Laura Brard, Thomas Harnois, Valérie Coronas, Bruno Constantin, Aurélien Chatelier, Jean Chemin, Serge Urbach, Martial Seveno, Szimonetta Hideg, Chantal Ripoll, Kasandra Aguilar‐Cázarez, Min Zheng, Guo‐Hao Huang, Sheng‐Qing Lv, Lei Zhang, Philippe Rondard, Laurent Prezeau, Jean‐Philippe Pin, Hugues Duffau, Luc Bauchet, Valérie Rigau, Franck Denat, Charles Truillet, Didier Boquet, Jean‐Philippe Hugnot   +36 more
wiley   +1 more source

ПЛАНИРОВАНИЕ КОМПЛЕКСНЫХ ВЫБОРОЧНЫХ ИСПЫТАНИЙ ИЗДЕЛИЙ ОДНОКРАТНОГО ПРИМЕНЕНИЯ НА НАДЕЖНОСТЬ С УЧЕТОМ АПРИОРНОЙ ИНФОРМАЦИИ

Sučasnì Informacìjnì Tehnologìï u Sferì Bezpeki ta Oboroni, 2014
Определены задачи планирования структурно-иерархичного выборочного контроля надежности изделий одноразового применения. Предложен подход к учету результатов эксплуатации однотипных изделий, их составных частей и элементов, а также результатов автономных ...
Vladyslav V. Kobziev, Pavlo V. Openko, Pavlo A. Drannyk, Yurii M. Koskov   +3 more
doaj  

Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma

Molecular Oncology, EarlyView.
The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic, Anne Nørremølle, Lilian Bomme Ousager, Lars van Brakel Andersen, Marie Louise Mølgaard Binderup, Mads Thomassen   +5 more
wiley   +1 more source