Results 101 to 110 of about 5,372,645 (294)
, 2018 A new methodology to solve the Reliability Index Approach (RIA) minimization problem with high levels of accuracy and still with practical efficiency is presented.
Carlos Alberto Conceição António +1 more
core +1 more source
Molecular Oncology, EarlyView.Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley +1 more source
RELATIVITY INDEX OF THE RELIABILITY OF SPACE SYSTEMS
International Journal of Computing, 2011 According to the special theory of relativity by Einstein, it can be affirmed that two events coincide in space only when objects are shown (or system of objects); according to latter the position of these events is defining. In this way the term “position in space” is relative too. When we talk about the position of one object in space – it’s actually
openaire +3 more sources
CEACAM1 participation in breast cancer progression
Molecular Oncology, EarlyView.In invasive breast cancer (BC), CEACAM1 shifts from an apical to a uniform membranous/cytoplasmic pattern, or is lost, as tumors dedifferentiate, inversely tracking the Ki‐67 proliferative index. In MCF‐7 cells, only CEACAM1‐4L suppresses proliferation, repressing cell cycle and growth factor genes.
Mykola Lyndin +3 more
wiley +1 more source
Integration of Reliability Concept into Soil Tillage Machine Design
Advanced Engineering Research, 2015 The main interest of designers is not only to determine the amplitudes of tillage forces but also the type of their distributions under different soil mechanical properties with object of achieving reliable designs.
Ghias Kharmanda, Imad Antypas
doaj +1 more source
Molecular Oncology, EarlyView.Tumour heterogeneity and clonal evolution of metastatic salivary gland cancer were evaluated in two patients with adenoid carcinoma and one patient with myoepithelial carcinoma. Radiology‐guided autopsy enabled multi‐region sampling (total samples n = 149), followed by whole‐genome sequencing and phylogenetic reconstruction (17 tumour samples, 4–7 per ...
Gerben Lassche +10 more
wiley +1 more source
ADP‐ribosylation: An emerging regulator of the epigenome
Molecular Oncology, EarlyView.ADP‐ribosylation has emerged as a dynamic epigenetic signaling mechanism that modifies histones and chromatin‐associated proteins. Through coordinated PARylation and MARylation, it integrates with other histone modifications to regulate chromatin structure, transcription factor activity, and gene expression, influencing genome function and disease ...
Cristel V. Camacho +2 more
wiley +1 more source
Fast Estimation for Reliability Index of Soil Subgrade Slopes Based on Safety Factor
工程科学与技术, 2023 Due to the complexity of reliability analysis of subgrade slopes, establishing a fast estimation method of reliability index β is of great help for the promotion of probability theory in engineering practice.
Qi WANG +3 more
doaj
Mechanisms and therapeutic opportunities of the ribotoxic stress response in cancer
Molecular Oncology, EarlyView.Cancer cells' high translational demand creates opportunities to therapeutically target ribosome function. Ribosome stalling and collisions activate ZAKα and the ribotoxic stress response (RSR), which can trigger rapid, p53‐independent apoptosis in cancer.
Anastassiya Kim +7 more
wiley +1 more source
Molecular Oncology, EarlyView.This study integrates publicly available transcriptomic datasets to identify molecular signatures associated with response to neoadjuvant chemoradiotherapy in locally advanced rectal cancer. By analyzing a combination of multiple cohorts with bioinformatics approaches, we reveal biological pathways and immune‐related features that may improve ...
Aleksandra Stanojevic +10 more
wiley +1 more source