Results 121 to 130 of about 1,358,459 (299)

A reliability-based robust design for structural components with a variable cross section under limited probabilistic information

Advances in Mechanical Engineering, 2017
In engineering design, structural components with variable cross sections are extensively employed due to their excellent mechanical properties. From a strength and stiffness perspective, structural components with a uniform cross section are not always ...
Tianxiao Zhang, David He
doaj   +1 more source

Metamodel-based importance sampling for the simulation of rare events

, 2011
In the field of structural reliability, the Monte-Carlo estimator is considered as the reference probability estimator. However, it is still untractable for real engineering cases since it requires a high number of runs of the model.
Deheeger, F., Dubourg, V., Sudret, B.
core   +2 more sources

Tumor‐stromal crosstalk and macrophage enrichment are associated with chemotherapy response in bladder cancer

FEBS Open Bio, EarlyView.
Chemoresistance in bladder cancer: Macrophage recruitment associated with CXCL1, CXCL5 and CXCL8 expression is characteristic of Gemcitabine/Cisplatin (Gem/Cis) Non‐Responder tumors (right side) while Responder tumors did not show substantial tumor‐stromal crosstalk (left side). All biological icons are attributed to Bioicons: carcinoma, cancerous‐cell‐
Sophie Leypold, Janik Riese, Lancelot Seillier, Mark Kühnel, Julia Pannhausen, Charlotte O. J. Fröhlich, Christian Martin, Peter Boor, Matthias Saar, Danny D. Jonigk, Nadine T. Gaisa, Michael Rose   +11 more
wiley   +1 more source

A light‐triggered Time‐Resolved X‐ray Solution Scattering (TR‐XSS) workflow with application to protein conformational dynamics

FEBS Open Bio, EarlyView.
Time‐resolved X‐ray solution scattering captures how proteins change shape in real time under near‐native conditions. This article presents a practical workflow for light‐triggered TR‐XSS experiments, from data collection to structural refinement. Using a calcium‐transporting membrane protein as an example, the approach can be broadly applied to study ...
Fatemeh Sabzian‐Molaei, Fredrik Orädd, Konstantinos Magkakis, Magnus Andersson   +3 more
wiley   +1 more source

Real time solar magnetograph Skylab mission Atlas [PDF]

An atlas of all magnetic field observations made during the Skylab missions with the Real Time Solar Magnetograph system located at the Marshall Space Flight Center is presented. Also included are a description of the system and its operation; an outline
Cumings, N. P., Hagyard, M. J.
core   +1 more source

Single‐molecule DNA flow‐stretch assays for high‐throughput DNA–protein interaction studies

FEBS Open Bio, EarlyView.
We describe an optimised single‐molecule DNA flow‐stretch assay that visualises DNA–protein interactions in real time. Linear DNA fragments are tethered to a surface and stretched by buffer flow for fluorescence imaging. Using λ and φX174 DNA, this protocol enhances reproducibility and accessibility, providing a versatile approach for studying diverse ...
Ayush Kumar Ganguli, Mohammad Nour Alsamsam, Ugnė Bagdonaitė, Van Truc Vu, Chun‐Jen Huang, Polina Kuzhir, Mindaugas Zaremba, Aurimas Kopūstas, Marijonas Tutkus   +8 more
wiley   +1 more source

Reliability sensitivity analysis

, 2014
Cette thèse porte sur l'analyse de sensibilité dans le contexte des études de fiabilité des structures. On considère un modèle numérique déterministe permettant de représenter des phénomènes physiques complexes.L'étude de fiabilité a pour objectif d'estimer la probabilité de défaillance du matériel à partir du modèle numérique et des incertitudes ...
openaire   +1 more source

Reliability and Sensitivity of Enode/Vmaxpro Sensor for Muscle Power Assessment

Life
(1) Background: Regardless of the level of physical activity, performance monitoring is a valuable component of the training process. The aim of this research was to assess the reliability and sensitivity of parameter measurements using the Enode/Vmaxpro
Milan Marković, Lazar Toskić, Veroljub Stanković, Radenko Arsenijević, Nikola Aksović, Bojan Bjelica, Saša Bubanj, Tatiana Dobrescu   +7 more
doaj   +1 more source

Analysing the significance of small conformational changes and low occupancy states in serial crystallographic data

FEBS Open Bio, EarlyView.
This protocol paper outlines methods to establish the success of a time‐resolved serial crystallographic experiment, by means of statistical analysis of timepoint data in reciprocal space and models in real space. We show how to amplify the signal from excited states to visualise structural changes in successful experiments.
Jake Hill, Yelyzaveta Pulnova, Elke De Zitter, Helen M. Ginn, Briony A. Yorke   +4 more
wiley   +1 more source

Screening and epitope characterization of Nidogen‐2‐specific nanobodies

FEBS Open Bio, EarlyView.
Camel immunization and phage display were employed to generate high‐affinity VHH nanobodies against Nidogen‐2. After library construction, biopanning, ELISA screening, sequencing, and recombinant expression, selected nanobodies were purified and characterized, leading to the preliminary exploration of a nanobody‐based sandwich ELISA for specific ...
Jianchuan Wen, Qianqian Cui, Zhongyun Lan, Yingjun Wang, Shuaiying Zhao, Wenxuan Feng, Yunfeng Liu, Qiting Huang, Dongna Zhang, Jianfeng Xu   +9 more
wiley   +1 more source