Results 41 to 50 of about 6,815,023 (244)
Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics
FEBS Letters, EarlyView.Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt +8 more
wiley +1 more source
Structural and biochemical analysis of a B12 superbinder
FEBS Letters, EarlyView.BtuG proteins are vitamin B12 scavengers in Bacteroides thetaiotaomicron, a dominant human gut bacterium. We present crystal structures of three BtuG homologs bound to cobalamin and its precursor cobinamide, revealing picomolar binding affinities, among the highest known for any natural protein.
Jose M. Martinez Felices +3 more
wiley +1 more source
Remote Sensing, 2020 At L-band (1–2 GHz), and particularly in microwave radiometry (1.413 GHz), vegetation has been traditionally modeled with the τ-ω model. This model has also been used to compensate for vegetation effects in Global Navigation Satellite Systems ...
Adriano Camps +5 more
doaj +1 more source
Research on Embedded Dual Operating System Architecture Based on Trusted Execution Environment [PDF]
Jisuanji gongcheng, 2019 To address the requirements of the embedded systems for functionality and real-time performance,this paper presents a dual operating system architecture.Based on the trusted execution environment provided by ARM TrustZone,the dual operating system ...
MENG Ziqi,ZHANG Qianying,SHI Zhiping,GUAN Yong
doaj +1 more source
The Shewanella oneidensis Fic enzyme SoFic targets the switch‐I region of EF‐Tu for AMPylation
FEBS Letters, EarlyView.Fic enzymes mediate diverse post‐translational modifications across all domains of life, including AMPylation. Prokaryotic EF‐Tu can be AMPylated and deAMPylated by the conserved Fic enzyme SoFic. Structural and biochemical approaches were used to characterize the effect of AMPylation on EF‐Tu, SoFic's enzymatic activities, and the enzyme‐target ...
Svenja Runge +6 more
wiley +1 more source
Experimental System for Monitoring and Diagnosis of a Static Power Converter
Advances in Electrical and Computer Engineering, 2013 The evolution of the computer aided design and control technologies in the field of static power converters leads also to diagnosis systems which include modules based on artificial intelligence. In order to achieve satisfactory reliability, the static
IVANOV, V. I. +2 more
doaj +1 more source
Metastatic niche shaped by host factors influences disseminated cancer cell fate
FEBS Letters, EarlyView.Metastasis is shaped not only by cancer cells but also by the environments they encounter. This review explores how factors such as aging, diet, the microbiome, lifestyle, and environmental exposures remodel organ‐specific niches in the lung, liver, bone, and brain, influencing where metastatic cells survive, remain dormant, or grow, and ultimately ...
Gwennan Delyth Ward +2 more
wiley +1 more source
MathematicsWe develop a closed-form analysis of the joint distribution for cumulative shock reliability systems with phase-type inter-shock times. The analytical literature on shock-driven reliability has hitherto been split into two largely separate traditions ...
Lotfi Tadj
doaj +1 more source
Implementation of a Testbed for GNSS-R Payload Performance Evaluation
IEEE Journal of Selected Topics in Applied Earth Observations and Remote Sensing, 2020 The functional performance of space-borne instruments must be validated on ground before and after satellite integration. The effects of radio-frequency interference are also becoming more important, even in protected bands for earth observation. In this
Adrian Perez +4 more
doaj +1 more source
Molecular Oncology, EarlyView.In the present work, we have identified a transcriptional signature based on the differential expression of six genes (BCL2&MAST4, HSH2D&LAT2, METRN&PITPNM2) that would facilitate the early detection of T‐cell acute lymphoblastic leukemia (T‐ALL) patients prone to a poor treatment response and could be implemented at diagnosis, along with other risk ...
Antonio Lahera +11 more
wiley +1 more source