Results 61 to 70 of about 1,877,205 (300)

Crucial parameters for precise copy number variation detection in formalin‐fixed paraffin‐embedded solid cancer samples

open access: yesMolecular Oncology, EarlyView.
This study shows that copy number variations (CNVs) can be reliably detected in formalin‐fixed paraffin‐embedded (FFPE) solid cancer samples using ultra‐low‐pass whole‐genome sequencing, provided that key (pre)‐analytical parameters are optimized.
Hanne Goris   +10 more
wiley   +1 more source

Analysis of the Component-Based Reliability in Computer Networks

open access: yesCubo, 2010
Performance in terms of reliability of computer networks motivates this paper. Limit theorems on the extreme queue length and extreme virtual waiting time in open queueing networks in heavy traffic are derived and applied to a reliability model for ...
Saulius Minkevi<img width=12 height=19 src="http:/fbpe/img/cubo/v12n1/img27.jpg">ius
doaj  

Progressive Reliability Method and Its Application to Offshore Mooring Systems [PDF]

open access: yes, 2013
Assessing the reliability of complex systems (e.g. structures) is essential for a reliability-based optimal design that balances safety and costs of such systems.
Mousavi, Mir Emad   +2 more
core   +1 more source

Phenotypic and genotypic characterization of single circulating tumor cells in the follow‐up of high‐grade serous ovarian cancer

open access: yesMolecular Oncology, EarlyView.
Single circulating tumor cells (sCTCs) from high‐grade serous ovarian cancer patients were enriched, imaged, and genomically profiled using WGA and NGS at different time points during treatment. sCTCs revealed enrichment of alterations in Chromosomes 2, 7, and 12 as well as persistent or emerging oncogenic CNAs, supporting sCTC identity.
Carolin Salmon   +9 more
wiley   +1 more source

A Critical Comparison of Alternative Risk Priority Numbers in Failure Modes, Effects, and Criticality Analysis

open access: yesIEEE Access, 2019
Risk priority number (RPN) is a widely used approach, and it is a powerful means to assess the criticality of modes in a failure modes, effects, and criticality analysis (FMECA) worksheet.
Lorenzo Ciani   +2 more
doaj   +1 more source

Tumor mutational burden as a determinant of metastatic dissemination patterns

open access: yesMolecular Oncology, EarlyView.
This study performed a comprehensive analysis of genomic data to elucidate whether metastasis in certain organs share genetic characteristics regardless of cancer type. No robust mutational patterns were identified across different metastatic locations and cancer types.
Eduardo Candeal   +4 more
wiley   +1 more source

HEAP: An Efficient and Fault-Tolerant Authentication and Key Exchange Protocol for Hadoop-Assisted Big Data Platform

open access: yesIEEE Access, 2018
Hadoop framework has been evolved to manage big data in cloud. Hadoop distributed file system and MapReduce, the vital components of this framework, provide scalable and fault-tolerant big data storage and processing services at a lower cost.
Durbadal Chattaraj   +5 more
doaj   +1 more source

A Parrondo Paradox in Reliability Theory

open access: yes, 2007
Parrondo's paradox arises in sequences of games in which a winning expectation may be obtained by playing the games in a random order, even though each game in the sequence may be lost when played individually. We present a suitable version of Parrondo's
Di Crescenzo, Antonio
core  

Colorectal cancer‐derived FGF19 is a metabolically active serum biomarker that exerts enteroendocrine effects on mouse liver

open access: yesMolecular Oncology, EarlyView.
Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley   +5 more
wiley   +1 more source

Strategic defense and attack for series and parallel reliability systems: reply to rejoinder [PDF]

open access: yes
Kovenock and Roberson’s (2012ab) replication of Hausken’s (2008a) equations and parameter restrictions do not enhance our insight into the defense and attack of reliability systems. This reply intends to fill the remaining understanding gaps.Game theory;
Hausken, Kjell
core   +1 more source

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