Results 51 to 60 of about 2,282,673 (287)
Ain Shams Journal of Anesthesiology, 2020 Background The fixed contracture deformity (FCD) which is often present in patients awaiting total knee replacement (TKR) affects the surgical outcome. Therefore, it is necessary to reduce the severity of the FCD before the TKR surgery.
Jadon Ashok +3 more
doaj +1 more source
Molecular Oncology, EarlyView.Clinical trials on PARP inhibitors in urothelial carcinoma (UC) showed limited efficacy and a lack of predictive biomarkers. We propose SLFN5, SLFN11, and OAS1 as UC‐specific response predictors. We suggest Talazoparib as the better PARP inhibitor for UC than Olaparib.
Jutta Schmitz +15 more
wiley +1 more source
Matching missions: hunger relief programs and impact of food donation partners in Northwest Arkansas [PDF]
, 2015 In 2012 and 2013, Arkansas ranked first in the nation in food insecurity in both categories of “low food secure” (21.2%) and “very low food secure” (8.4%).
Popp, Jennie, West, Amy May
core +2 more sources
JA Clinical ReportsBackground Spinal extradural arachnoid cysts (SEACs) can cause persistent pain after surgery. Combining spinal cord stimulation (SCS) with structured exercise therapy may aid long-term pain modulation.
Akari Ikemura +8 more
doaj +1 more source
BMC Nutrition, 2017 Background Despite global efforts, stunting remains a public health problem in several developing countries. The prevalence of stunting among 0- to 5-year-old children in Armenia has increased from 17% in 2000 to 19% in 2010.
Arin A. Balalian +4 more
doaj +1 more source
Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma
Molecular Oncology, EarlyView.Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken +7 more
wiley +1 more source
Molecular Oncology, EarlyView.Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon +13 more
wiley +1 more source
Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment
Molecular Oncology, EarlyView.This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley +1 more source
Theory of Change Review: A Report Commissioned by Comic Relief [PDF]
, 2011 Comic Relief does three things. It raises much needed cash, it then allocates that cash to projects in the United States and in the poorest countries in the world, and it raises awareness of the issues it feels strongly about.
Cathy James
core
Spontaneous formation of optically induced surface relief gratings [PDF]
, 2009 A model based on Fick's law of diffusion as a phenomenological description of the molecular motion, and on the coupled mode theory, is developped to describe single-beam surface relief grating formation in azopolymers thin films. It allows to explain the
Bellini B +8 more
core +4 more sources