Results 41 to 50 of about 237,453 (287)

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Remaining oil distribution rule after polymer flooding in Daqing oilfield

, 2010
Figuring out the rule of remaining oil distribution after polymer flooding is the basis for continuing study on development policy after polymer flooding in Daqing oil Field.
C Guan, Tian, X., Song, K., J Zhang, Zhang, J., Guan, C., K Song, X Tian   +7 more
core   +1 more source

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

The Rapid Quantitative Description of the Remaining Oil

, 2015
At the late development stage of an oilfield, the distribution and potential evaluation of remaining oil is the key to comprehensive adjustment. Only if the location and quantity of the remaining oil is clear, can the targeted adjustment measures be made.
LIU, Jiyu, PAN, Mingxi, YOU, Haili, DONG, Wei   +3 more
core   +1 more source

Experimental characterization and mechanism of hydraulic pulsation waves driving microscopic residual oil

Petroleum Exploration and Development, 2022
To clarify microscopic mechanisms of residual oil displacement by hydraulic pulsation wave, microscopic visualization experiments of hydraulic pulsation wave driving residual oil were carried out by using the microscopic visualization device of pulsating
Feipeng WU, Na LI, Wei YANG, Jiahao CHEN, Bujie DING, Lei XIA, Jing LIU, Cong WANG, Lushan WANG   +8 more
doaj   +1 more source

An isoform of 14‐3‐3 protein regulates transbilayer lipid movement at the plasma membrane

FEBS Letters, EarlyView.
Loss of 14‐3‐3ζ in CHO cells confers resistance to exogenous phosphatidylserine (PS) and impairs endocytosis‐independent inward flip‐flop of fluorescent PS at the plasma membrane. RNAi‐mediated knockdown reproduces this defect, while no additive effect is seen in ATP11C‐deficient cells.
Akiko Yamaji‐Hasegawa, Akira Hattori, Masafumi Tsujimoto, Toshihide Kobayashi   +3 more
wiley   +1 more source

Residual tail twisting in ascidian larvae is stabilized by asymmetric myofibrils that resist bilateral symmetry restoration

FEBS Letters, EarlyView.
Ascidian Ciona larvae initially show strong clockwise tail twisting, which is largely corrected during development. However, a small residual twist remains. This study shows that organized helical myofibrils in tail muscles mechanically stabilize this residual asymmetry, preventing complete restoration of bilateral symmetry and revealing how embryos ...
Yuki S. Kogure, Misaki K. Nishio, Satoru Okuda, Kohji Hotta   +3 more
wiley   +1 more source

Structural insights and therapeutic targets in Acinetobacter baumannii capsule biosynthesis

FEBS Letters, EarlyView.
Hypervirulent KL49 A. baumannii's capsular polysaccharide contains the nonulosonic acid 8‐epi‐Leg5,7Ac2, synthesized by epimerization via ElaA, ElaB, and ElaC. Crystal structures of ElaA, ElaB, and ElaC reveal their role in CMP‐Leg5,7Ac2 synthesis and regioselective C8 epimerization.
Woo Cheol Lee, Junho Jeong, Chae Yeong Lee, Hyunjoon Cho, Man Hwan Oh, Je Chul Lee, Jee‐Young Lee, Yangmee Kim   +7 more
wiley   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Study on the regularity of the development of fracture Remaining Oil in Taizhao Oil Field

Journal of Physics: Conference Series, 2020
Abstract According to the data gathered from 49 core wells in Taizhao Oil Field, there are 17 wells without fractures and 32 wells with obvious fractures. Despite an average of 7.1 fractures in each well, there are 10 fractures in W426, W424 and W406 respectively in Taizhao Oil layer.
openaire   +1 more source