Results 1 to 10 of about 59,932 (250)
Functional properties of measles virus proteins derived from a subacute sclerosing panencephalitis patient who received repeated remdesivir treatments
Journal of VirologySubacute sclerosing panencephalitis (SSPE) is a rare but fatal late neurological complication of measles, caused by persistent measles virus (MeV) infection of the central nervous system. There are no drugs approved for the treatment of SSPE.K. Schmitz, Kim Handrejk, Lelde Liepina, Lisa Bauer, Griffin D Haas, Fabiënne van Puijfelik, E. Veldhuis Kroeze, Marta Riekstina, J. Strautmanis, Huyen Cao, R. Verdijk, C. Geurtsvankessel, Sander van Boheemen, D. van Riel, Benhur Lee, M. Porotto, R. D. de Swart, R. D. de Vries +17 moresemanticscholar +1 more sourceCardiac Adverse Events and Remdesivir in Hospitalized Patients With COVID-19: A Post Hoc Safety Analysis of the Randomized DisCoVeRy Trial
Clinical Infectious DiseasesBackground We aimed to evaluate the cardiac adverse events (AEs) in hospitalized patients with coronavirus disease 2019 (COVID-19) who received remdesivir plus standard of care (SoC) compared with SoC alone (control), as an association was noted in some ...Vida Terzić, Joe Miantezila Basilua, Nicolas Billard, Lucie de Gastines, D. Belhadi, C. Fougerou-Leurent, Nathan Peiffer-Smadja, N. Mercier, C. Delmas, Assia Ferrane, A. Dechanet, J. Poissy, Hélène Espérou, F. Ader, Maya Hites, C. Andrejak, R. Greil, J. Paiva, Thérèse Staub, E. Tacconelli, C. Burdet, D. Costagliola, F. Mentré, Y. Yazdanpanah, A. Diallo +24 moresemanticscholar +1 more sourceJournal Club [PDF]
, 2020 Outline Review coronavirus life-cycle Review mechanism of action of remdesivir Review previous research on remdesivir Close reading of article - Methods - Results - Discussion Future research Implications for our ...Uzumcu, MD, Zeynepcore +1 more sourceEfficacy and Safety of Remdesivir in People With Impaired Kidney Function Hospitalized for COVID-19 Pneumonia: A Randomized Clinical Trial
Clinical Infectious DiseasesBackground Few antiviral therapies have been studied in patients with coronavirus disease 2019 (COVID-19) and kidney impairment. Herein, the efficacy, safety, and pharmacokinetics of remdesivir, its metabolites, and sulfobutylether-β-cyclodextrin ...M. Sise, J. R. Santos, Jason D. Goldman, Katherine R. Tuttle, J. P. Teixeira, Allan F Seibert, Yiannis Koullias, Joe Llewellyn, Sean Regan, Yang Zhao, H. Huang, Robert H. Hyland, Anu Osinusi, Helen Winter, Rita Humeniuk, H. Hulter, Robert L Gottlieb, Dahlene N. Fusco, Rita Birne, Fernando Stancampiano, C. Libertin, Catherine B Small, Markus Plate, Mark J McPhail, Rosa Rita Luis Gil João Paulo Ana Andre Antonio Moncef Ballesteros Birne Malheiro Silva Correia Vida Silv, Rosa Ballesteros, Rita Birne, Luís Malheiro, Gil Silva, João Paulo Correia, Ana Vida, Andre Silva, António Carujo, Moncef Belhassen Garcia, Jordi Carratala Fernandez, Gabriela Abelenda-Alonso, J. Cruzado, Alexander Rombauts, Diego A Sandoval, M. G. Deltoro, Fransesc Puchades Gimeno, Neus Gómez-Muñoz, María Martínez Roma, Juan Horcajada Gallego, Castañeda Pablo, Padilla Urrea Silvia, Rial Crestelo Sergio, Santos Fernandez David, Ramon Jose, Susanna Benet, Rosa Benítez, Carmen Bracke, A. Chamorro, Sergio España, F. Graterol, Gemma Lladós, Cristina López, L. Mateu, R. Paredes, Boris Rebollo, Alba Romero, Laura Soldevila, Elena Abad, Alba San José, Alex Soriano Viladomiu, Mark J McPhail, Nicholas Medjeral-Thomas, S. Lobo, Igor Abolnik, Anjali Acharya, Leland Allen, Keith A. Bellovich, Mary Jane Burton, Miriam Cameron, Gerard J. Criner, L.-Y.H. Criner, Joseph Lambert, Marium Rashid, H. Shore-Brown, George A. Diaz, David Dougherty, Nathaniel Erdmann, Dahlene N. Fusco, Jason D. Goldman, William Berrington, Christine Logar, N. Vadivel, Allison Everett, Gonzalez Suarez Maria Lourdes, Robert L Gottlieb, M. Berhe, Gates Colbert, Christopher Hebert, Ankit Mehta, C. Spak, Lorie Estrada, R. Vargas, Jennifer Choe, Alex Pham, L. Mason, Catherine Tallmadge, Ariana Braddom, Maldonado Nicholas, Aayla Jamil, Ashley McAllister, Christina Guerra, T. Sam, Edilia Solis, D. Gotur, Munish Goyal, Farrukh Koraishy, Brett Laurence, Vinay Malhotra, Luis A Manrique, J. McKinnell, Blaithin A McMahon, Ruth Campbell, Caryn Morse, J. Navarro, Luis Ostrosky, Bela Patel, Carolyn Z. Grimes, Maria Hernandez, M. Mammadova, Laura Nielsen, Virginia Umana, Tobias Pusch, Philip Robinson, Arun J. Sanyal, Harry Schrager, Jason Mallada, Allan F Seibert, Marc Siegel, M. Sise, J. Slim, Catherine B Small, P. Sriram, Fernando Stancampiano, J. P. Teixeira, Krystle D. Apodaca, M. Harkins, Amy G. Cunningham, Katherine R. Tuttle +142 moresemanticscholar +1 more sourceAssessing the effect of remdesivir alone and in combination with corticosteroids on time to death in COVID-19: A propensity score-matched analysis
Journal of Clinical Virology PlusBackground: This study aimed to evaluate the impact of remdesivir, alone or in combination with corticosteroids, on the time to death in COVID-19 patients. Methods: This retrospective cohort study was conducted between March 20, 2020, and March 18, 2021, Mohamad Amin Pourhoseingholi, Mehdi Azizmohammad Looha, Saba Ilkhani, Hamidreza Hatamabadi, Amir Sadeghi, Seyed Amir Ahmad Safavi-Naini, Kamran Heidari, Nazanin Taraghikhah, Mohammad Mahdi Fallah, Reyhaneh Kalantar, Nariman Naderi, Romina Esbati, Nastaran Ebrahimi, Ali Solhpour, Tannaz Jamialahmadi, Amirhossein Sahebkar +15 moredoaj +1 more sourceSARS-CoV-2 RNA and nucleocapsid antigen are blood biomarkers associated with severe disease outcomes that improve in response to remdesivir.
Journal of Infectious DiseasesBACKGROUND
Although antivirals remain important for the treatment COVID-19, methods to assess treatment efficacy are lacking. Here, we investigated the impact of remdesivir on viral dynamics and their contribution to understanding antiviral efficacy in ...Kanal Singh, Kevin Rubenstein, Viviane Callier, K. Shaw-Saliba, Adam W. Rupert, Robin L. Dewar, S. Laverdure, Helene Highbarger, P. Lallemand, Meei-Li W Huang, Keith R Jerome, R. Sampoleo, Margaret G. Mills, A. Greninger, K. Juneja, D. Porter, Constance A Benson, Walla Dempsey, Hana M. El Sahly, Chris Focht, N. Jilg, Catharine I. Paules, Rekha R Rapaka, T. Uyeki, H. C. Lane, J. Beigel, Lori E. Dodd, Aneesh K. Mehta, N. Rouphael, J. Traenkner, Valeria D. Cantos, Ghina Alaaeddine, Barry S. Zingman, R. Grossberg, Paul F. Riska, Elizabeth Hohmann, Mariam Torres-Soto, N. Jilg, Helen Y Chu, Anna Wald, Margaret L Green, Anne F. Luetkemeyer, Pierre-Cedric B. Crouch, Hannah Jang, Susan Kline, Joanne Billings, B. Noren, Diego López de Castilla, Jason W. Van Winkle, Francis X. Riedo, Robert W. Finberg, Jennifer P. Wang, Mireya Wessolossky, Kerry Dierberg, Benjamin Eckhardt, Henry J. Neumann, V. Tapson, Jonathan Grein, F. Sutterwala, L. Hsieh, Alpesh N Amin, Thomas F. Patterson, H. Javeri, Trung Vu, Roger Paredes, L. Mateu, Daniel A. Sweeney, Constance A Benson, Farhana Ali, William R. Short, P. Tebas, J. Torgersen, G. Touloumi, V. Gioukari, D. Lye, Sean W. X. Ong, N. Ohmagari, Ayako Mikami, G. Fätkenheuer, J. Malin, P. Koehler, Andre C. Kalil, L. Larson, Angela Hewlett, M. Kortepeter, C. B. Creech, Isaac Thomsen, Todd W. Rice, Babafemi O. Taiwo, Karen Krueger, Stuart H. Cohen, George R Thompson, Cameron Wolfe, E. Walter, Maria Frank, Heather Young, A. Falsey, A. Branche, Paul A. Goepfert, Nathaniel Erdmann, Otto O. Yang, Jenny Ahn, Anna L. Goodman, B. Merrick, Richard M. Novak, Andrea Wendrow, H. Arguinchona, Christa Arguinchona, Sarah L George, Janice Tennant, R. Atmar, Hana M. El Sahly, Jennifer A. Whitaker, D. A. Price, C. J. Duncan, S. Metallidis, T. Chrysanthidis, F. McLellan, M. Oh, W. Park, E. S. Kim, Jongtak Jung, J. R. Ortiz, K. Kotloff, Brian Angus, Jack David Germain Seymour, Noreen A. Hynes, Lauren M. Sauer, Neera Ahuja, Kari C Nadeau, Patrick E H Jackson, Taison D Bell, A. Antoniadou, K. Protopapas, Richard T Davey, J. Voell, José Muñoz, M. Roldán, I. Kalomenidis, S. Zakynthinos, Catharine I. Paules, Fiona McGill, J. Minton, N. Koulouris, Z. Barmparessou, Edwin Swiatlo, Kyle Widmer, N. Huprikar, A. Ganesan, Guillermo M. Ruiz-Palacios, Alfredo Ponce de Leon, Sandra Rajme, Justino Regalado Pineda, J. Martínez-Orozco, M. Holodniy, Aarthi Chary, Timo Wolf, C. Stephan, J. Wasmuth, Christoph Boesecke, M. Llewelyn, Barbara Philips, C. Colombo, R. Colombo, D. Lindholm, Katrin Mende, Tida Lee, T. Lalani, R. Maves, G. Utz, Jens Lundgren, M. Helleberg, J. Gerstoft, Thomas Benfield, T. Jensen, B. Lindegaard, Lothar Weise, L. Knudsen, I. Johansen, L. W. Madsen, Lars Østergaard, N. Stærke, Henrik Nielsen, Timothy H. Burgess, Michelle Green, M. Makowski, Jennifer L. Ferreira, Michael R. Wierzbicki, Tyler Bonnett, Nikki Gettinger, Theresa Engel, Jing Wang, J. Beigel, Kay M. Tomashek, S. Nayak, Lori E. Dodd, Walla Dempsey, Effie Y. H. Nomicos, Marina Lee, Peter Wolff, Rhonda Pikaart-Tautges, Mohamed Elsafy, Robert Jurao, Hyung Koo, Michael A Proschan, Dean A Follmann, H. C. Lane +206 moresemanticscholar +1 more sourceRemdesivir is Associated with Reduced Mortality in Patients Hospitalized for COVID-19 Not Requiring Supplemental Oxygen
Open Forum Infectious DiseasesBackground Remdesivir has demonstrated benefit in some hospitalized patients with coronavirus disease 2019 (COVID-19) on supplemental oxygen and in nonhospitalized patients breathing room air.E. Mozaffari, Aastha Chandak, Chidinma Chima-Melton, Andre C. Kalil, Heng Jiang, EunYoung Lee, C. Der-Torossian, M. Thrun, Mark Berry, R. Haubrich, R. Gottlieb +10 moresemanticscholar +1 more source
