Results 41 to 50 of about 39,201 (181)

In Search for Effective and Safe Drugs Against SARS-CoV-2: Part III] the Electronic Factors of Remdesivir and the Naturally Extracted Aspirochlorine Drugs [PDF]

, 2020
This report is associated with an ongoing coronavirus outbreak. We selected Remdesivir (used in the treatment of Ebola) and Aspirochlorine (a natural product found in Aspergillus oryzae), and their binding to specific peptide sequences of the coronavirus
Yousra, Abdel-Mottaleb, M. Sabry, Abdel-Mottaleb   +1 more
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Consistent Effects of Early Remdesivir on Symptoms and Disease Progression Across At-Risk Outpatient Subgroups: Treatment Effect Heterogeneity in PINETREE Study

Infectious Diseases and Therapy, 2023
Introduction In the PINETREE study, early remdesivir treatment reduced risk of coronavirus disease 2019 (COVID-19)-related hospitalizations or all-cause death versus placebo by 87% by day 28 in high-risk, non-hospitalized patients. Here we report results
Samuel M. Brown, Morgan J. Katz, Adit A. Ginde, Kavita Juneja, Monica Ramchandani, Joshua T. Schiffer, Carlos Vaca, Robert L. Gottlieb, Yuan Tian, Emon Elboudwarej, Joshua A. Hill, Richard Gilson, Lauren Rodriguez, Charlotte Hedskog, Shuguang Chen, Jairo M. Montezuma-Rusca, Anu Osinusi, Roger Paredes   +17 more
doaj   +1 more source

The Ethical Allocation of Remdesivir Within Hospitals

, 2021
Recent evidence has shown that remdesivir may shorten length of hospital stay and recovery in COVID-19 patients. Many hospitals are experiencing shortages of remdesivir and are being forced to determine systems for the ethical allocation of this drug ...
Comer, Amber R.
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The effect of remdesivir on selective biomarkers and its value in predicting the clinical outcome in patients with COVID-19

Asian Journal of Medical Sciences, 2021
Background: To the best of our knowledge, there have been no studies to evaluate the effect of remdesivir on inflammatory markers. Aims and Objectives: To study the effect of Remdesivir on Selective biomarkers namely C-Reactive Protein (CRP), Lactate ...
Sanjana Rai , Dyna Jones , Chinnappa Anjanappa Jayashankar , Venkata Bharat Kumar Pinnelli , Eashwer Manpreeth , Venkata Sai Raghava Prashanthi Seetha   +5 more
doaj   +1 more source

Remdesivir and its antiviral activity against COVID-19: A systematic review

Clinical Epidemiology and Global Health, 2021
Background: The aim of this study was to summarize the antiviral activities of remdesivir against SARS-CoV-2, the causative agent of COVID-19. Methods: Available publications were systematically explored on some databases and gray literature was examined.
Andri Frediansyah, Firzan Nainu, Kuldeep Dhama, Mudatsir Mudatsir, Harapan Harapan   +4 more
doaj   +1 more source

Remdesivir vs. covid-19

, 2020
COVID-19 is a disease caused by the SARS-COV-2 virus. The virus first appeared in China in the city of Wuhan. The virus that infected other countries as well. It is a threat to the health and life of society.
Oleś, Izabela
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Intermolecular Interaction Among Remdesivir, RNA and RNA-Dependent RNA Polymerase of SARS-CoV-2 Analyzed by Fragment Molecular Orbital Calculation [PDF]

, 2020
COVID-19, a disease caused by a new strain of coronavirus (SARS-CoV-2) originating from Wuhan, China, has now spread around the world, triggering a global pandemic, leaving the public eagerly awaiting the development of a specific medicine and vaccine ...
Koichiro, Kato, Kaori, Fukuzawa, Teruki, Honma   +2 more
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Remdesivir for severe covid-19: a clinical practice guideline [PDF]

, 2020
Clinical question What is the role of remdesivir in the treatment of severe covid-19? This guideline was triggered by the ACTT-1 trial published in the New England Journal of Medicine on 22 May 2020.
Kanda, Seema, Appiah, John Adabie, Zeng, Linan, Kwizera, Arthur, Vandvik, Per Olav, Ge, Long, Kurian, Linda, Ye, Zhikang, Bartoszko, Jessica, Gershengorn, Hayley B, Geduld, Heike, Kawano-Dourado, Leticia, Silvestre, Maria Asuncion, Siemieniuk, Reed, Guyatt, Gordon, Qadir, Nida, Agarwal, Arnav, Huang, Minhua, Manai, Hela, Agoritsas, Thomas, Rochwerg, Bram, Brignardello-Petersen, Romina, Gershengorn, Hayley B., Zeraatkar, Dena, Ergan, Begum, Lamontagne, François, Leo, Yee-Sin, Murthy, Srinivas   +27 more
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Acute pancreatitis or severe increase in pancreatic enzyme levels following remdesivir administration in COVID-19 patients: an observational study

Scientific Reports, 2022
Remdesivir has been shown to reduce recovery time and mortality among patients with coronavirus disease 2019 (COVID-19). However, data regarding the efficacy and safety of remdesivir use are limited in Japan.
Kazuhito Miyazaki, Yukihiro Yoshimura, Nobuyuki Miyata, Hiroaki Sasaki, Aya Shiba, Masaharu Aga, Yusuke Hamakawa, Yuri Taniguchi, Yuki Misumi, Yoko Agemi, Tsuneo Shimokawa, Hiroaki Okamoto, Natsuo Tachikawa   +12 more
doaj   +1 more source

Remdesivir-Induced Bradycardia.

, 2023
Remdesivir, a viral RNA-dependent RNA polymerase inhibitor, found extensive use in coronavirus disease 2019-infected patients because it curbs the viral load expansion.
Dholiya, Hardeep, Jhajj, Poonam, Jain, Rohit, Kanagala, Sai Gautham, Wu, Shiau-Ing, Gupta, Vasu, Gupta, Sachin, Patel, Meet A   +7 more
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