Results 31 to 40 of about 49,641 (173)

An open-label, randomized, single intravenous dosing study to investigate the effect of fixed-dose combinations of tenofovir/lamivudine or atazanavir/ritonavir on the pharmacokinetics of remdesivir in Ugandan healthy volunteers (RemTLAR)

Trials, 2021
Background Remdesivir is a novel broad-spectrum antiviral therapeutic with activity against several viruses that cause emerging infectious diseases.
Stephen I. Walimbwa, Julian P. Kaboggoza, Catriona Waitt, Pauline Byakika-Kibwika, Antonio D’Avolio, Mohammed Lamorde   +5 more
doaj   +1 more source

Identification of bradycardia following remdesivir administration through the US Food and Drug Administration American College of Medical Toxicology COVID-19 Toxic Pharmacovigilance Project [PDF]

, 2023
IMPORTANCE: The rapid spread and mortality associated with COVID-19 emphasized a need for surveillance system development to identify adverse events (AEs) to emerging therapeutics.
Abston, Stephanie, Aldy, Kim, Brent, Jeffrey, Burkhart, Keith, Campleman, Sharan, Devgun, Jason M, Meyn, Alison, Toxicology Investigators Consortium FACT Study Group,, Wax, Paul, Zhang, Rongmei   +9 more
core   +3 more sources

Cardiovascular events and safety outcomes associated with remdesivir using a World Health Organization international pharmacovigilance database

Clinical and Translational Science, 2022
On October 2020, the US Food and Drug Administration (FDA) approved remdesivir as the first drug for the treatment of coronavirus disease 2019 (COVID‐19), increasing remdesivir prescriptions worldwide.
Se Yong Jung, Min Seo Kim, Han Li, Keum Hwa Lee, Ai Koyanagi, Marco Solmi, Andreas Kronbichler, Elena Dragioti, Kalthoum Tizaoui, Sarah Cargnin, Salvatore Terrazzino, Sung Hwi Hong, Ramy Abou Ghayda, Nam Kyun Kim, Seo Kyoung Chung, Louis Jacob, Joe‐Elie Salem, Dong Keon Yon, Seung Won Lee, Karel Kostev, Ah Young Kim, Jo Won Jung, Jae Young Choi, Jin Soo Shin, Soon‐Jung Park, Seong Woo Choi, Kiwon Ban, Sung‐Hwan Moon, Yun Young Go, Jae Il Shin, Lee Smith   +30 more
doaj   +1 more source

Remdesivir treatment in hospitalized patients affected by COVID-19 pneumonia: a case-control study [PDF]

, 2022
Background: to date the optimal antiviral treatment against severe coronavirus disease 2019 (COVID-19) has not been proven; remdesivir is a promising drug with in vitro activity against several virus, but in COVID-19 the clinical results are currently ...
Bianchi, Bianca, Boglione, Lucio, Borrè, Silvio, Dodaro, Valentina, Esposito, Maria, Meli, Giulia, Moglia, Roberta, Poletti, Federica, Rostagno, Roberto   +8 more
core   +1 more source

High-throughput rational design of the remdesivir binding site in the RdRp of SARS-CoV-2: implications for potential resistance

iScience, 2021
Summary: The use of remdesivir to treat COVID-19 will likely continue before clinical trials are completed. Due to the lengthening pandemic and evolving nature of the virus, predicting potential residues prone to mutation is crucial for the management of
Aditya K. Padhi, Rohit Shukla, Prakash Saudagar, Timir Tripathi   +3 more
doaj   +1 more source

A Systematic Review of therapeutic agents for the treatment of the Middle East Respiratory Syndrome Coronavirus (MERS-CoV) [PDF]

, 2019
Background The Middle East Respiratory Syndrome Coronavirus (MERS-CoV) was first described in 2012 and attracted a great international attention due to multiple healthcare associated outbreaks.
Al-Ali, Anfal Y., Al-Tawfiq, Jaffar A., Momattin, Hisham   +2 more
core   +1 more source

Remdesivir in Very Old Patients (≥80 Years) Hospitalized with COVID-19: Real World Data from the SEMI-COVID-19 Registry [PDF]

, 2022
Background: Large cohort studies of patients with COVID-19 treated with remdesivir have reported improved clinical outcomes, but data on older patients are scarce.
Abella Vázquez, Lucy, Areses Manrique, Maria, Asensi, Victor, Cobos Palacios, Lidia, Cossio Tejido, Santiago de, Díez García, Luis Felipe, Guisado Vasco, Pablo, Gómez Huelgas, Ricardo, Lumbreras Bermejo, Carlos, López Carmona, María Dolores, López Sampalo, Almudena, Martinez Cilleros, Carmen, Martinez Pascual, Angeles, Martín Escalante, María Dolores, Martínez Gonzalez, Angel Luís, Muiño Miguez, Antonio, Ramos Rincon, Jose Manuel, Ripper, Carlos Jorge, Rubio Rivas, Manuel, Taboada Martínez, María Luisa, The Semi-covid-19 Network, Tuñón de Almeida, Carlota   +21 more
core   +1 more source

Is remdesivir the therapeutic answer for COVID-19: a review of current knowledge [PDF]

, 2020
As the world races to find the solution to the COVID-19 pandemic, an investigational agent which has triggered worldwide interest is remdesivir. Though failing clinical trials for treatment of Ebola virus disease, remdesivir has shown efficacy in ...
Ahsan, Marya, Mallick, Ayaz Khurram
core   +2 more sources

Rapid Response to Remdesivir in Hospitalised COVID-19 Patients:A Propensity Score Weighted Multicentre Cohort Study [PDF]

, 2023
Introduction: Remdesivir is a registered treatment for hospitalised patients with COVID-19 that has moderate clinical effectiveness. Anecdotally, some patients’ respiratory insufficiency seemed to recover particularly rapidly after initiation of ...
Arbous, Sesmu M., Benard, Menno R., Bosma, Liesbeth B.E., de Boer, Mark G.J., Delfos, Nathalie M., Dol, Lisa, El Bouazzaoui, Lahssan H., Groenwold, Rolf H.H., Knevel, Rachel, Leegwater, Emiel, Mollema, Femke P.N., Ottens, Thomas H., Roelofsen, Eveline E., Rosendaal, Frits R., van Burgel, Nathalie D., van der Feltz, Machteld, van Nieuwkoop, Cees, Visser, Leo G., Visser, Loes E., Wilms, Erik B.   +19 more
core   +3 more sources

Effect of remdesivir on mortality and the need for mechanical ventilation among hospitalized patients with COVID-19: real-world data from a resource-limited country

International Journal of Infectious Diseases, 2023
Objectives: Georgia introduced remdesivir for the treatment of COVID-19 in December 2020. We evaluated the real-world effect of remdesivir on mortality and the need for mechanical ventilation among inpatients with COVID-19.
Revaz Metchurtchlishvili, Nikoloz Chkhartishvili, Akaki Abutidze, Marina Endeladze, Marine Ezugbaia, Ana Bakradze, Tengiz Tsertsvadze   +6 more
doaj   +1 more source