Results 31 to 40 of about 37,793 (186)

Modification of Remdesivir as a Better Inhibitor of COVID-19: A Computational Docking Study

, 2020
Coronavirus (COVID-19) mediated infection is a highly contagious respiratory illness that was initially found in Wuhan city of Hubei Province in China. The ongoing pandemic of the novel SARS-CoV-2 virus is affecting global health.
Md. Lutful, Kabir, Tasnin, Al Hasib, Kazi Ahsan, Ahmed, Mita, Shikder   +3 more
core   +1 more source

Effect of remdesivir on mortality and the need for mechanical ventilation among hospitalized patients with COVID-19: real-world data from a resource-limited country

International Journal of Infectious Diseases, 2023
Objectives: Georgia introduced remdesivir for the treatment of COVID-19 in December 2020. We evaluated the real-world effect of remdesivir on mortality and the need for mechanical ventilation among inpatients with COVID-19.
Revaz Metchurtchlishvili, Nikoloz Chkhartishvili, Akaki Abutidze, Marina Endeladze, Marine Ezugbaia, Ana Bakradze, Tengiz Tsertsvadze   +6 more
doaj   +1 more source

Activation of the urotensin-II receptor by remdesivir induces cardiomyocyte dysfunction

Communications Biology, 2023
Remdesivir is an antiviral drug used for COVID-19 treatment worldwide. Cardiovascular side effects have been associated with remdesivir; however, the underlying molecular mechanism remains unknown.
Akiko Ogawa, Seiya Ohira, Yuri Kato, Tatsuya Ikuta, Shota Yanagida, Xinya Mi, Yukina Ishii, Yasunari Kanda, Motohiro Nishida, Asuka Inoue, Fan-Yan Wei   +10 more
doaj   +1 more source

Remdesivir-Bound and Ligand-Free Simulations Reveal the Probable Mechanism of Inhibiting the RNA Dependent RNA Polymerase of SARS-CoV-2

, 2020
The efforts towards developing a potential drug against the current global pandemic, COVID-19, has increased in the past few months. Drug development strategies to target the RNA dependent RNA polymerase (RdRP) are being tried worldwide.
Uddhavesh, Sonavane, Rajendra, Joshi, Shruti, Koulgi, Vinod, Jani, Mallikarjunachari, Uppuladinne V N   +4 more
core   +1 more source

Viruses by Remdesivir

, 2021
Remdesivir is an antiviral drug initially designed against the Ebola virus. The results obtained with it both in biochemical studies in vitro and in cell line assays in vivo were very promising, but it proved ineffective in clinical trials.
Lisi, George P., Wang, Jimin, Reiss, Krystle, Yuanjun Shi, Batista, Victor S., Victor S. Batista, Shi, Yuanjun, Elias Lolis, George P. Lisi, Lolis, Elias, Jimin Wang, Krystle Reiss   +11 more
core   +1 more source

Summary of remdesivir allocation strategies.

, 2021
Summary of remdesivir allocation strategies.
Karishma Desai (7516163), Ilene Harris (4110925), Sanchari Ghosh (11576840), Sabeen Ali (11576843), Zippora Kiptanui (8787014)   +4 more
core   +1 more source

Direct and Catalytic C-Glycosylation of Arenes: Expeditious Synthesis of the Remdesivir Nucleoside

, 2021
Since early 2020, scientists have strived to find an effective solution to fight SARS-CoV-2, especially by developing reliable vaccines that inhibit the spread of the disease and repurposing drugs for combatting its effects on the human body.
Benjamin, List, Sebastian A., Schwengers, Markus, Leutzsch, Benjamin, Mitschke, Carla, Obradors, Sebastian, Brunen, Miles H., Aukland, Oleg, Grossmann   +7 more
core   +1 more source

Remdesivir (GS-5734) Impedes Enterovirus Replication Through Viral RNA Synthesis Inhibition

Frontiers in Microbiology, 2020
Human enteroviruses are responsible for diverse diseases, from mild respiratory symptoms to fatal neurological complications. Currently, no registered antivirals have been approved for clinical therapy.
Wei Ye, Min Yao, Yangchao Dong, Chuantao Ye, Dan Wang, He Liu, Hongwei Ma, Hui Zhang, Libin Qi, Yuewu Yang, Yuan Wang, Liang Zhang, Linfeng Cheng, Xin Lv, Zhikai Xu, Yingfeng Lei, Fanglin Zhang   +16 more
doaj   +1 more source

Hemoadsorption eliminates remdesivir from the circulation: Implications for the treatment of COVID‐19

Pharmacology Research & Perspectives, 2021
Both antiviral treatment with remdesivir and hemoadsorption using a CytoSorb® adsorption device are applied in the treatment of severe COVID‐19. The CytoSorb® adsorber consists of porous polymer beads that adsorb a broad range of molecules, including ...
Paul Biever, Dawid L. Staudacher, Michaela J. Sommer, Hannah Triebel, Merja A. Neukamm, Christoph Bode, Alexander Supady, Achim Lother   +7 more
doaj   +1 more source

Prominent bradycardia in a COVID-19 patient receiving Remdesivir: a case report

Qanun Medika: Jurnal Kedokteran Fakultas Kedokteran Universitas Muhammadiyah Surabaya, 2022
Remdesivir is a commonly used antiviral drug to treat COVID-19. Remdesivir has some side effects; however, whether it has any effect on cardiac is rarely reported.
Sidhi Laksono Purwowiyoto, Grace Trifena Hosea   +1 more
doaj   +1 more source