Results 61 to 70 of about 37,793 (186)

In Search for Effective and Safe Drugs Against SARS-CoV-2: Part III] the Electronic Factors of Remdesivir and the Naturally Extracted Aspirochlorine Drugs

, 2020
This report is associated with an ongoing coronavirus outbreak. We selected Remdesivir (used in the treatment of Ebola) and Aspirochlorine (a natural product found in Aspergillus oryzae), and their binding to specific peptide sequences of the coronavirus
Yousra, Abdel-Mottaleb, M. Sabry, Abdel-Mottaleb   +1 more
core   +1 more source

COMPARISON AND DRUG UTILISATION STUDY OF CORTICOSTEROID (METHYLPREDNISOLONE) WITH REMDESIVIR V/S REMDESIVIR IN COVID-19 PATIENTS

, 2023
Due to the 2019 pandemic caused because to the coronavirus disease (Covid-19) has led to the investigation of different drugs for their efficacy and therapeutic benefits for people suffering from the Covid-19 illness because of its high prevalence, easy ...
Ismath Bano, Nazakath Shaista Fatima, Bushra Sereen, Nishath Fatima, Dr. Mohammed Ashfaq Hussain*
core   +1 more source

Characterization of Lysosomal Hydrolases and Transporters and Their Age‐Dependent Variability: Relevance to Drug Metabolism and Transport of Small Molecule and Biologic Drugs

Clinical Pharmacology &Therapeutics, EarlyView.
Lysosomes play a key role in the accumulation, catabolism, and transport of endogenous and exogenous metabolites and proteins and are involved in drug metabolism and prodrug activation. However, the protein abundance and interindividual variability of lysosomal drug‐metabolizing enzymes and transporters (DMETs) remain underexplored.
Darshak Gadara, Dilip Kumar Singh, Sandhya Subash, Guihua Yue, Deepak Ahire, Chris Bohl, Maciej Czerwinski, Stephanie Helmstetter, Scott Heyward, Robert S. Jones, Cyrus Khojasteh, Ryota Kikuchi, Priyanka Kulkarni, Bin Ma, Bernard Murray, Chris Seib, Bill Smith, David M. Stresser, Mitchell E. Taub, Ting Wang, Bhagwat Prasad   +20 more
wiley   +1 more source

Intermolecular Interaction Among Remdesivir, RNA and RNA-Dependent RNA Polymerase of SARS-CoV-2 Analyzed by Fragment Molecular Orbital Calculation

, 2020
COVID-19, a disease caused by a new strain of coronavirus (SARS-CoV-2) originating from Wuhan, China, has now spread around the world, triggering a global pandemic, leaving the public eagerly awaiting the development of a specific medicine and vaccine ...
Koichiro, Kato, Kaori, Fukuzawa, Teruki, Honma   +2 more
core   +1 more source

Remdesivir: from Ebola to COVID-19

, 2021
Human coronaviruses (HCoV) were discovered in the 1960s and were originally thought to cause only mild upper respiratory tract diseases in immunocompetent hosts.
Maria Gabriella Santoro
core   +1 more source

Protective Effect of Remdesivir Against Pulmonary Fibrosis in Mice

Frontiers in Pharmacology, 2021
Pulmonary fibrosis is a known sequela of severe or persistent lung damage. Existing clinical, imaging and autopsy studies have shown that the lungs exhibit a pathological pulmonary fibrosis phenotype after infection with coronaviruses, including severe ...
Xiaohe Li, Xiaohe Li, Rui Liu, Rui Liu, Yunyao Cui, Yunyao Cui, Jingjing Liang, Jingjing Liang, Zhun Bi, Shimeng Li, Shimeng Li, Yang Miao, Liang Zhang, Xiaoping Li, Honggang Zhou, Honggang Zhou, Cheng Yang, Cheng Yang   +17 more
doaj   +1 more source

Longitudinal 1H and 129Xe Lung MRI in Patients With Post‐COVID Residual Lung Abnormalities

Journal of Magnetic Resonance Imaging, EarlyView.
ABSTRACT Background It is unclear how lung function may recover in patients with residual lung abnormalities (RLAs) following COVID‐19 pneumonia. Purpose To evaluate lung function trends over time in patients with RLAs following hospitalization due to COVID‐19. Study Type Prospective, multicenter longitudinal cohort study.
Laura C. Saunders, Guilhem J. Collier, Laurie J. Smith, Ho‐Fung Chan, Paul J. C. Hughes, Scarlett Strickland, Lotta Gustafsson, Thomas Newman, Megan Plowright, Zoë Gabriel, Lily M. Pearce, James T. Grist, Kher Lik Ng, Arthur Harrison, Charlotte E. Bolton, Jody Bray, Helen Marshall, Graham Norquay, Alberto M. Biancardi, Jimmy E. Ball, Neil J. Stewart, Kevin M. Johnson, Andrew J. Swift, Smitha Rajaram, John Blaikley, Stefan Stanel, Paul J. Collini, Gary H. Mills, Rod Lawson, Jonathan Brooke, Amanda T. Goodwin, Iain D. Stewart, Ling‐Pei Ho, Joseph Jacob, Thomas Meersmann, Galina E. Pavlovskaya, Fergus Gleeson, Ian P. Hall, Gisli Jenkins, Jim M. Wild, A. A. Roger Thompson, on behalf of the UK‐ILD consortium   +41 more
wiley   +1 more source

Remdesivir for the treatment of COVID‐19

, 2021
BACKGROUND: Remdesivir is an antiviral medicine with properties to inhibit viral replication of SARS‐CoV‐2. Positive results from early studies attracted media attention and led to emergency use authorisation of remdesivir in COVID‐19.
Benstöm, Carina, Ansems, Kelly, Stegemann, Miriam, Benstoem, Carina, Mikolajewska, Agata, Piechotta, Vanessa, Grundeis, Felicitas, Thieme, Volker, Dahms, Karolina, Metzendorf, Maria-Inti, Fichtner, Falk   +10 more
core   +1 more source

Trends in the development of remdesivir based inventions against COVID-19 and other disorders: A patent review

Journal of Infection and Public Health, 2021
The development of remdesivir has been a breakthrough for COVID-19 treatment. It has been approved in about 50 countries, including Saudi Arabia, since 2020. The generic structure of remdesivir was first disclosed in 2009.
Mohd. Imran, Ahmed Subeh Alshrari, Syed Mohammed Basheeruddin Asdaq, Abida   +3 more
doaj   +1 more source

Association of Salivary Micro Ribonucleic Acid Levels With the Severity of Severe Acute Respiratory Syndrome Coronavirus 2 Infection in Children

Pediatric Discovery, EarlyView.
This cohort study of 395 children (mean age 7 years) with SARS‐CoV‐2 demonstrates that measuring levels of miR‐296‐5p in saliva at the time of initial clinical presentation may aid the prognosis of severe symptoms. ABSTRACT Severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) may impact immune‐related micro ribonucleic acids (miRNAs).
Steven D. Hicks, Dongxiao Zhu, Nirupama Kannikeswaran, Kathleen Meert, Wei Chen, Rhea Sullivan, Srinivasan Suresh, Usha Sethuraman   +7 more
wiley   +1 more source