Results 91 to 100 of about 37,793 (186)

Remdesivir Strongly Binds to both RNA-dependent RNA Polymerase and Main Protease of SARS-CoV-2: Evidence from Molecular Simulations

, 2020
The outbreak of a new coronavirus SARS-CoV-2 (severe acute respiratory syndrome–coronavirus 2) has caused a global CoVid-19 (coronavirus disease 2019) pandemic, resulting in millions of infections and thousands of deaths around the world.
Duc Toan, Truong, Hoang Linh, Nguyen, Thai, Nguyen, Mai Suan, Li   +3 more
core   +1 more source

When serious becomes critical

Journal of Hospital Medicine, EarlyView.
Yohei Masuda
wiley   +1 more source

Intravenous lanadelumab for the treatment of moderately ill COVID‐19 patients

British Journal of Clinical Pharmacology, Volume 92, Issue 6, Page 1685-1695, June 2026.
Aims Kallikrein‐kinin system (KKS) dysregulation is hypothesized to play a pathogenetic role in COVID‐19‐associated pulmonary oedema. To investigate the efficacy and safety of intravenous lanadelumab, a monoclonal antibody that inhibits plasma kallikrein, in COVID‐19, we conducted a phase 2, open‐label, randomized‐controlled, proof‐of‐concept ...
Job J. Engel, Christine van Linge, W. Joost Wiersinga, Ilse J. E. Kouijzer, Quirijn de Mast, Robert‐Jan Hassing, Danique J. H. Huijbens, Helen L. Leavis, Roger Schutgens, Coen Maas, Kit C. B. Roes, Frank L. van de Veerdonk, Roger Brüggemann   +12 more
wiley   +1 more source

ProTides for Antiviral Activity Beyond Liver Cells

Chemistry – A European Journal, Volume 32, Issue 21, 1 June 2026.
A strategy for obtaining prodrugs of antiviral nucleotides with broad tissue activity is presented that relies on cycloalkyl or cycloalkylalkyl esters, improving uptake and esterase cleavage, and producing nanomolar inhibitors in kidney, colon, and lung cells.
Felix Goebel, Adrian Humboldt, Heeyoung Kim, Carl J. M. Schölzel, Ralf Bartenschlager, Clemens Richert   +5 more
wiley   +1 more source

Significance and Usefulness of High‐Resolution 24‐h Electrocardiographic Parameters in Patients With Coronavirus Disease 2019 After Admission: A Prospective Cohort Study

Journal of Arrhythmia, Volume 42, Issue 3, June 2026.
In patients with coronavirus disease 2019 (COVID‐19) without an obvious cardiac disease, ambulatory electrocardiographic markers can be useful in assessing the risk of severe disease. Particularly, simultaneous positivity of late potential (LP) and T wave alternans (TWA) in patients with COVID‐19 was a poorer prognostic factor than LP or TWA alone ...
Motohiro Kimata, Kenichi Hashimoto, Naomi Harada, Yusuke Kawamura, Yoshifumi Kimizuka, Mayuko Kaneko, Nobuaki Kiriu, Yasumasa Sekine, Natsumi Iwabuchi, Tetsuro Kiyozumi, Susumu Matsukuma, Yuji Tanaka, Nobutaka Hirooka   +12 more
wiley   +1 more source

Unveiling the Power of Deuterium in Drug Discovery: A Comprehensive Overview

MedComm, Volume 7, Issue 6, June 2026.
The role of deuterium replacement in drug discovery, its progress, opportunities, and challenges. ABSTRACT Deuterium, the heavy isotope of hydrogen, has unfolded as a cornerstone in modern drug discovery due to its potential to influence metabolic stability and pharmacokinetic behavior.
Mukta Lele, Ajit Manchare, Swapnali Parit, Amol D. Gholap, Krishna Jadhav, Navnath Hatvate, Keshav Raj Paudel, Satish Rojekar   +7 more
wiley   +1 more source

DataSheet2_Protective Effect of Remdesivir Against Pulmonary Fibrosis in Mice.ZIP

, 2021
Pulmonary fibrosis is a known sequela of severe or persistent lung damage. Existing clinical, imaging and autopsy studies have shown that the lungs exhibit a pathological pulmonary fibrosis phenotype after infection with coronaviruses, including severe ...
Jingjing Liang (413293), Xiaoping Li (48167), Rui Liu (54031), Zhun Bi (5599538), Honggang Zhou (3879853), Yang Miao (653676), Shimeng Li (1483378), Yunyao Cui (7380509), Cheng Yang (273624), Liang Zhang (41392), Xiaohe Li (3162627)   +10 more
core   +1 more source

Repurposed Medicines for Viruses With Epidemic or Pandemic Potential: A Horizon Scan

Pharmacology Research &Perspectives, Volume 14, Issue 3, June 2026.
ABSTRACT Viruses such as Ebola, Marburg, influenza, mpox, MERS‐CoV, SARS‐CoV, and SARS‐CoV‐2 may be considered pathogens of epidemic or pandemic concern. Developing novel antiviral medicines can be time‐consuming and resource intensive. Repurposing existing medicines with known or potential antiviral activity offers a faster, cost‐effective strategy to
Sola Akinbolade, Rhiannon Potter, Alex Inskip, Jane Nesworthy, Kirsti Brock, Gill Norman   +5 more
wiley   +1 more source

DataSheet1_Protective Effect of Remdesivir Against Pulmonary Fibrosis in Mice.ZIP

, 2021
Pulmonary fibrosis is a known sequela of severe or persistent lung damage. Existing clinical, imaging and autopsy studies have shown that the lungs exhibit a pathological pulmonary fibrosis phenotype after infection with coronaviruses, including severe ...
Jingjing Liang (413293), Xiaoping Li (48167), Rui Liu (54031), Zhun Bi (5599538), Honggang Zhou (3879853), Yang Miao (653676), Shimeng Li (1483378), Yunyao Cui (7380509), Cheng Yang (273624), Liang Zhang (41392), Xiaohe Li (3162627)   +10 more
core   +1 more source

Successful in vitro propagation of feline coronavirus from clinically diagnosed feline infectious peritonitis cases using Vero cells: A potential model for future research

Veterinary Record Open, Volume 13, Issue 1, June 2026.
Abstract Background Feline coronavirus (FCoV) causes inapparent to progressive fatal feline infectious peritonitis (FIP) in domestic and wild cats, which affects multiple‐organ systems. Methods We investigated three clinically sick cats using different laboratory and molecular tests to diagnose and confirm FCoV and propagate the virus in Vero cell ...
Eaftekhar Ahmed Rana, Mahfuza Akther, Susan Beetson, Subir Sarker, Gabriele Rossi, Jasim M. Uddin   +5 more
wiley   +1 more source