Results 91 to 100 of about 49,641 (173)

Different SARS‐CoV‐2 Subvariants and Coagulation Markers Trend: A Retrospective Multicentric Study From Iranian Network for Research in Viral Diseases (INRVD)

Health Science Reports, Volume 9, Issue 4, April 2026.
ABSTRACT Background and Aims This study aims to examine the prevalence and progression of coagulation disorders in adult COVID‐19 patients and evaluate the effect of severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) on coagulation markers. Methods This retrospective study included 1885 hospitalized COVID‐19 patients, aged 20 to over 90 years,
Alireza Razavi, Masoud Pourghahramani Koltapeh, Tina Nazari, Arefe Morvaridi, Behrooz Banivaheb, Sepideh Saeb, Melina Moulaeian, Alireza Zakaryaei, Arash Sabzalian, Maedeh Raei, Bahar Razavi, Saeed Motlaghzadeh, Somayeh Sadat Hosseini, Hassan Karami, Parsa Ghafari, Amir Aboofazeli, Sogol Nastarvand, Negin Kaseb navaz Sarabi, Alex Avakian, Sara Ebadinejad, Tara Keyhani, Parand Danafar, Rozhin Rahimlou, Sedigheh Heidarian, Mozhgan Mondeali, Fatemeh Nafe‐Monfared, Mobina Jafarpour, Marziyeh Samiee, Fatemeh Birang, Amirhossein Mirzazadeh, Seyed Ariana Feiz Abadi, Khabat Barkhordari, Saba Siavoshi, Mahdi Biklari, Mohammad khodabakhsh, AmirHossein Javadi, Samaneh Mirzaee, Farshideh Didgar, Mostafa Etebari, Saedeh Soltanmohamad, Babak Shahbaz, Ebrahim Kord, Seyed Mohammad Hashemi Shahri, Majid Ebrahimzade, Alireza Ansari Moghaddam, Fariba Shahraki Sanavi, Afagh Moattari, Fahime Edalat, Majid Fardi Sheijani, Mohsen Moghadami, Tofigh Yaghubi, Ali Mojtahedi, Abtin Heidarzadeh, Mohammadreza Naghipour, Maryam Sharifi Luyeh, Pershang Nazemi, Kian Alipasandi, Maryam Albaji, Mahdieh Afzali, Nasim Shokouhi, Akram Ezani, Hamid reza Najari, Mirshamsedin Hosseini, Arefeh Ghobadi, Abdoalmabood Momeni, Seyedeh Zeinab Fattahi, Mehdi Mohsenzadeh, Mohammad Jafari, Adeleh Azizi, Sajad Pouryousef, Alijan Tabarraei, Abdolvahab Moradi, Sadeghali Azimi, Yousef Yahyapour, Masoumeh Bayani, Vahdat Poortahmasebi, Mojtaba Varshochi, Masood Ziaee, Shokouh Ghafari, Davod Javanmard, Alireza Soleimani, Sayed‐Hamidreza Mozhgani, Zakiye Mokhames, Zohreh Akhoundimeybodi, Akram Astani, Alireza Abdollahi, Azar Hadadi, Mohammad reza Salehi, Mahboubeh Hajiabdolbaghi, Seyed Reza Raeeskarami, Samira kafan, Mahnaz Montazeri, Marzieh Pazoki, Taghi Riahi, Mahshid Talebi‐Taher, Angila Ataei‐Pirkooh, Farah Bokharaei‐Salim, Seyed Hamid Reza Faiz, Saeed Kalantari, Zeinab Yasin, Seyed Mohammad Jazayeri   +100 more
wiley   +1 more source

COVID‐19 Prophylactic Effect of Bromhexine Hydrochloride

Immunity, Inflammation and Disease, Volume 14, Issue 4, April 2026.
ABSTRACT Introduction Despite extensive efforts to identify effective treatments for COVID‐19, preventive strategies remain essential. Bromhexine hydrochloride (BRH), an over‐the‐counter mucolytic with potential TMPRSS2 inhibition, may reduce viral entry and thus serve as a prophylactic agent.
Vanyo Mitev, Tsanko Mondeshki, Ani Miteva, Konstantin Tachkov, Violeta Dimitrova   +4 more
wiley   +1 more source

Lycorine Derivative Inhibits SARS‐CoV‐2 Replication by Reducing −1 Programmed Ribosomal Frameshifting via Targeting ZAP

MedComm, Volume 7, Issue 4, April 2026.
The present study evaluated the antiviral potential of various lycorine derivatives and identified compound 7 as a promising candidate. Compound 7 demonstrated strong antiviral efficacy against both the original SARS‐CoV‐2 and its variants in vitro and in vivo.
Tingfu Du, Ruixue Liu, Xintian Zhang, Longying Shen, Cong Tang, Junbin Wang, Yu Cheng, Wenhai Yu, Bin Yin, Shuaiyao Lu, Xiandao Pan, Xiaozhong Peng   +11 more
wiley   +1 more source

A Rare Case of Pulmonary Ossification Findings That Rapidly Progressed and Improved During the Course of COVID‐19 Pneumonia

Respirology Case Reports, Volume 14, Issue 4, April 2026.
We report a case of pulmonary ossification findings that rapidly progressed and improved during the course of COVID‐19 pneumonia. ABSTRACT An 88‐year‐old man with a history of myocardial infarction, non‐valvular atrial fibrillation and hypothyroidism was admitted to our hospital with a diagnosis of coronavirus disease.
Chie Hirama, Arisa Mitsuo, Yuichi Kato, Iori Motohashi, Kenya Ie, Taku Tanaka, Chiaki Okuse, Shigeki Fujitani   +7 more
wiley   +1 more source

Antivirals Targeting Coronavirus RNA‐Dependent RNA Polymerase and Main Protease: From Mechanisms of Action to Outcomes in COVID‐19 Clinical Trials

Microbial Biotechnology, Volume 19, Issue 4, April 2026.
The target sites of COVID‐19 antivirals discussed in the present opinion paper, namely the RNA dependent RNA polymerase Nsp12 and of the main viral protease Nsp5, are indicated by a red star in the overview of the replication cycle of coronavirus SARS‐CoV‐2.
Harald Brüssow
wiley   +1 more source

Management of Vulnerable Patients Hospitalized for COVID-19 With Remdesivir: A Retrospective Comparative Effectiveness Study of Mortality in US Hospitals. [PDF]

BACKGROUND: Coronavirus disease 2019 (COVID-19) remains a major public health concern, with continued resurgences of cases and substantial risk of mortality for hospitalized patients.
Ahuja, Neera, Amin, Alpesh, Berry, Mark, Casciano, Roman, Chandak, Aastha, Doi, Yohei, Kolditz, Martin, Loubet, Paul, Mozaffari, Essy, Müller, Veronika, Sax, Paul   +10 more
core   +1 more source

Journal Club [PDF]

, 2020
Outline Review coronavirus life-cycle Review mechanism of action of remdesivir Review previous research on remdesivir Close reading of article - Methods - Results - Discussion Future research Implications for our ...
Uzumcu, MD, Zeynep
core   +1 more source

Remdesivir as a possible therapeutic option for the COVID-19 [PDF]

, 2020
Al-Homoud, Ali H., Al-Tawfiq, Jaffar A., Memish, Ziad A.   +2 more
core   +1 more source

Remdesivir-Associated Survival Outcomes Among Immunocompromised Patients Hospitalized for COVID-19: Real-world Evidence From the Omicron-Dominant Era. [PDF]

BACKGROUND: Patients with immunocompromising conditions are at increased risk for coronavirus disease 2019 (COVID-19)-related hospitalizations and deaths.
Amin, Alpesh, Berry, Mark, Chandak, Aastha, Chima-Melton, Chidinma, Gottlieb, Robert, Kalil, Andre, Mozaffari, Essy, Sax, Paul   +7 more
core   +1 more source

Assessing the effect of remdesivir alone and in combination with corticosteroids on time to death in COVID-19: A propensity score-matched analysis

Journal of Clinical Virology Plus
Background: This study aimed to evaluate the impact of remdesivir, alone or in combination with corticosteroids, on the time to death in COVID-19 patients. Methods: This retrospective cohort study was conducted between March 20, 2020, and March 18, 2021,
Mohamad Amin Pourhoseingholi, Mehdi Azizmohammad Looha, Saba Ilkhani, Hamidreza Hatamabadi, Amir Sadeghi, Seyed Amir Ahmad Safavi-Naini, Kamran Heidari, Nazanin Taraghikhah, Mohammad Mahdi Fallah, Reyhaneh Kalantar, Nariman Naderi, Romina Esbati, Nastaran Ebrahimi, Ali Solhpour, Tannaz Jamialahmadi, Amirhossein Sahebkar   +15 more
doaj   +1 more source