Results 81 to 90 of about 39,201 (181)

A Phase I study of the pharmacokinetics (PK), bioavailability, dose proportionality, safety, and tolerability of topiramate injection compared to Oral topiramate in healthy adult participants

Epilepsia, EarlyView.
Abstract This Phase I study evaluated the safety, tolerability, and pharmacokinetics of a 30‐min topiramate injection (intravenous [IV] TPM) infusion compared with oral topiramate (oral TPM) in healthy adult participants. In this randomized, open‐label, dose escalation, crossover study with 37 healthy participants received single doses of 50, 100, or ...
Adeboye O. Bamgboye, James C. Cloyd, Bernard D. King, Lisa D. Coles   +3 more
wiley   +1 more source

Impact of remdesivir use on budget.

, 2022
Impact of remdesivir use on budget.
Guillaume Béraud (2558941), Jean-François Timsit (58724), Henri Leleu (449520)   +2 more
core   +1 more source

Efficacy and Safety of Remdesivir in Hospitalized Pediatric COVID-19: A Retrospective Case-Controlled Study

, 2023
Ahmed Khalil,1 Asmaa Mohamed,1 Manasik Hassan,2 Samar Magboul,2 Hossamaldein Ali,1 Ahmed Salah Elmasoudi,1 Khaled Ellithy,3 Mohammad Qusad,2 Abdulla Alhothi,2 Eman Al Maslamani,4 Mohammed Al Amri,5 Ashraf Soliman5 1Section of Pediatric Clinical Pharmacy,
Ali H, Alhothi A, Hassan M, Al Amri M, Khalil A, Mohamed A, Elmasoudi AS, Soliman A, Magboul S, Ellithy K, Qusad M, Al Maslamani E   +11 more
core  

Remdesivir treatment for patients with moderate to severe COVID-19

, 2022
Background/aim: Remdesivir, which was first developed for the treatment of Ebola disease but failed to meet expectations, has become hope in the fight against the COVID-19 pandemic. This study aimed to evaluate risk factors for mortality and prognosis of
Tabak, Fehmi, Yasar, Kadriye Kart, Batirel, Ayse, TELLİ DİZMAN, GÜLÇİN, Cagatay, Arif Atahan, HASANOĞLU, İMRAN, Gül, Ahmet, Sevgi, Dilek Yıldız, Bozkurt, Ilkay, Alp, Emine, Guner, Rahmet, KANAT, FİKRET, Eren, Esma, Senoglu, Sevtap, KARAALİ, RIDVAN, KAZAK, ESRA, Celikbas, Aysel, ÜNAL, SERHAT, Erdinc, Sebnem, Sevgi, Dilek Yildiz, PULLUKÇU, HÜSNÜ, Karaali, Rıdvan, Celik, Ilhami, Dizman, Gülçin Telli   +23 more
core   +1 more source

Critical role of vaccination in preventing severe coronavirus disease 2019: perspectives from clinical outcomes in an Australian kidney transplant recipient cohort

Internal Medicine Journal, EarlyView.
Abstract Background Kidney transplant recipients (KTRs) disproportionately experience severe COVID‐19 infections. We previously identified concern regarding vaccine‐induced rejection as a barrier to vaccine uptake. Aim This study assesses COVID‐19 vaccine uptake, infection outcomes and allograft rejection in KTRs during the delta and omicron waves (BA ...
Dhakshayini Tharmaraj, Paayal Naidu, Mohana Baptista, Sarah McBride, Rhonda Stuart, Claire Dendle, Kevan R. Polkinghorne, William R. Mulley   +7 more
wiley   +1 more source

DataSheet3_Protective Effect of Remdesivir Against Pulmonary Fibrosis in Mice.docx

, 2021
Pulmonary fibrosis is a known sequela of severe or persistent lung damage. Existing clinical, imaging and autopsy studies have shown that the lungs exhibit a pathological pulmonary fibrosis phenotype after infection with coronaviruses, including severe ...
Jingjing Liang (413293), Xiaoping Li (48167), Rui Liu (54031), Zhun Bi (5599538), Honggang Zhou (3879853), Yang Miao (653676), Shimeng Li (1483378), Yunyao Cui (7380509), Cheng Yang (273624), Liang Zhang (41392), Xiaohe Li (3162627)   +10 more
core   +1 more source

Experimental methods in chemical engineering: Cyclic voltammetry—CV

The Canadian Journal of Chemical Engineering, Volume 104, Issue 11, Page 5776-5827, November 2026.
Abstract Cyclic voltammetry (CV) is a foundational electroanalytical technique for investigating redox behaviour and evaluating material performance across fields such as molecular electrochemistry, electrocatalysis, sensing, and energy storage. Despite its widespread use, a gap remains between formal electrochemical theory and the practical data ...
Yasser Matos‐Peralta, Christopher Panaritis, JoElen Hagler, Clara Santato, Gregory S. Patience   +4 more
wiley   +1 more source

Quantitative analysis of two COVID-19 antiviral agents, favipiravir and remdesivir, in spiked human plasma using spectrophotometric methods; greenness evaluation

BMC Chemistry, 2023
Favipiravir and remdesivir have been included in the COVID-19 treatment guidelines panel of several countries. The main objective of the current work is to develop the first validated green spectrophotometric methods for the determination of favipiravir ...
Afnan S. Batubara, Ahmed H. Abdelazim, Ahmed A. Almrasy, Mohammed Gamal, Sherif Ramzy   +4 more
doaj   +1 more source

Hitting Coronaviruses Where It Hurts: Antiviral Strategies Targeting Viral Proteins

ChemMedChem, Volume 21, Issue 19, 14 October 2026.
Viral proteins represent key vulnerabilities in human coronaviruses (HCoVs). This review outlines inhibitors targeting spike (S), main protease (Mpro), papain‐like protease (PLpro), and RNA‐dependent RNA polymerase (RdRp), mapping chemically diverse strategies that disrupt entry and replication, and provides an integrated view of current candidates ...
Álvaro de la Cruz‐Potenciano, Miguel Maldonado, María‐José Camarasa, Sonia de Castro   +3 more
wiley   +1 more source

Searching for Novel COVID19 Treatments: Towards Covalent TMPRSS2 Inhibitors

ChemMedChem, Volume 21, Issue 19, 14 October 2026.
We designed, synthesised, and evaluated new guanidine derivatives as potential covalent inhibitors of TMPRSS2, a key protease for SARS‐CoV‐2 entry. Computational studies showed that some compounds have improved binding over nafamostat. However, experimentally none effectively blocked viral entry in cell assays, indicating further optimisation is needed.
Marco Minneci, Barbara Farkaš, Adeyemi Rahman, Inga Nehlmeier, Amy Eichmann, Stefan Pöhlmann, Isabel Rozas   +6 more
wiley   +1 more source