Results 71 to 80 of about 39,201 (181)

Trends in the development of remdesivir based inventions against COVID-19 and other disorders: A patent review

Journal of Infection and Public Health, 2021
The development of remdesivir has been a breakthrough for COVID-19 treatment. It has been approved in about 50 countries, including Saudi Arabia, since 2020. The generic structure of remdesivir was first disclosed in 2009.
Mohd. Imran, Ahmed Subeh Alshrari, Syed Mohammed Basheeruddin Asdaq, Abida   +3 more
doaj   +1 more source

4′‐ThioRNA Substitution and Sense‐Strand Segmentation for the Design of Functional Fully Modified siRNAs Targeting SARS‐CoV‐2

Chemistry – A European Journal, EarlyView.
4′‐ThioRNA was broadly tolerated across multiple positions in SARS‐CoV‐2‐targeting siRNAs, but full 4'‐thio modification of both strands caused a reduction in RNAi activity. Sense‐strand segmentation improved RNAi and antiviral activity, particularly when the nick was located at position 10 from the 5′‐end of the sense strand, thereby unlocking the ...
Yuhei Nogi, Jun Tsukimoto, Noriko Saito‐Tarashima, Takaaki Koma, Masako Nomaguchi, Noriaki Minakawa   +5 more
wiley   +1 more source

Remdesivir: from Ebola to COVID-19

, 2021
Human coronaviruses (HCoV) were discovered in the 1960s and were originally thought to cause only mild upper respiratory tract diseases in immunocompetent hosts.
Maria Gabriella Santoro
core   +1 more source

Comparative assessment of favipiravir and remdesivir against human coronavirus NL63 in molecular docking and cell culture models

Scientific Reports, 2021
Human coronavirus NL63 (HCoV-NL63) mainly affects young children and immunocompromised patients, causing morbidity and mortality in a subset of patients.
Yining Wang, Pengfei Li, Sajjan Rajpoot, Uzma Saqib, Peifa Yu, Yunlong Li, Yang Li, Zhongren Ma, Mirza S. Baig, Qiuwei Pan   +9 more
doaj   +1 more source

Characterization of Lysosomal Hydrolases and Transporters and Their Age‐Dependent Variability: Relevance to Drug Metabolism and Transport of Small Molecule and Biologic Drugs

Clinical Pharmacology &Therapeutics, EarlyView.
Lysosomes play a key role in the accumulation, catabolism, and transport of endogenous and exogenous metabolites and proteins and are involved in drug metabolism and prodrug activation. However, the protein abundance and interindividual variability of lysosomal drug‐metabolizing enzymes and transporters (DMETs) remain underexplored.
Darshak Gadara, Dilip Kumar Singh, Sandhya Subash, Guihua Yue, Deepak Ahire, Chris Bohl, Maciej Czerwinski, Stephanie Helmstetter, Scott Heyward, Robert S. Jones, Cyrus Khojasteh, Ryota Kikuchi, Priyanka Kulkarni, Bin Ma, Bernard Murray, Chris Seib, Bill Smith, David M. Stresser, Mitchell E. Taub, Ting Wang, Bhagwat Prasad   +20 more
wiley   +1 more source

Association Between Use of Remdesivir and Bradycardia

, 2022
Remdesivir received the first emergency use authorization from the FDA for the treatment of COVID-19. Multiple adverse drug reactions (ADR) have been reported since its approval in October 2020.
Umeukeje, Gibret
core  

Remdesivir for the treatment of COVID‐19

, 2021
BACKGROUND: Remdesivir is an antiviral medicine with properties to inhibit viral replication of SARS‐CoV‐2. Positive results from early studies attracted media attention and led to emergency use authorisation of remdesivir in COVID‐19.
Benstöm, Carina, Ansems, Kelly, Stegemann, Miriam, Benstoem, Carina, Mikolajewska, Agata, Piechotta, Vanessa, Grundeis, Felicitas, Thieme, Volker, Dahms, Karolina, Metzendorf, Maria-Inti, Fichtner, Falk   +10 more
core   +1 more source

Toward Secure Supply of Remdesivir via a 2-Pot Triazine Synthesis: Supply Centered Synthesis [PDF]

, 2020
Pyrrolotriazine 1 is an important precursor to Remdesivir, and an efficient synthesis is disclosed. This route features atom economy and reduced derivatization of starting materials, by making use of highly abundant, commoditized raw material inputs ...
Flavio S. P., Cardoso, Rodger W., Stringham, Joshua D., Sieber, Dinesh J., Paymode, Daniel W., Cook, B. Frank, Gupton, Justina, Burns, David, Snead, John W., Tomlin, Toolika, Agrawal   +9 more
core   +2 more sources

Remdesivir-induced severe hypoglycemia in an elderly man without diabetes: a case report

Journal of Pharmaceutical Health Care and Sciences
Background Remdesivir is recommended to treat hospitalized patients with coronavirus disease 2019 (COVID-19). Remdesivir is known to affect glucose metabolism in individuals with and without diabetes.
Yasunori Nagano, Hisae Aoki, Juri David, Naoko Iwahashi Kondo, Makimi Aizawa, Toshiyuki Sumita, Yuki Hamada, Yuki Yamamoto, Kaoru Yamada   +8 more
doaj   +1 more source

Cost-effectiveness of remdesivir for the treatment of hospitalized patients with COVID-19: a systematic review

Infectious Diseases of Poverty, 2023
Background Remdesivir is being studied and used to treat coronavirus disease 2019 (COVID-19). This study aimed to systematically identify, critically evaluate, and summarize the findings of the studies on the cost-effectiveness of remdesivir in the ...
Aziz Rezapour, Zahra Behroozi, Mostafa Nasirzadeh, Mohsen Rezaeian, Mohammad Barzegar, Mahsa Tashakori-Miyanroudi, Abdollah Sayyad, Aghdas Souresrafil   +7 more
doaj   +1 more source