Results 101 to 110 of about 49,641 (173)

Remdesivir inhibits endothelial activation and atherosclerosis by coupling TAL1 to TRAF6

Journal of Translational Medicine
Background Atherosclerosis is characterized by complex pathological processes, including endothelial dysfunction and inflammation. The underlying pathogenic mechanisms have been well elucidated; however, effective treatments are yet to be validated.
Hanning Zhang, Ruru Li, Qianqian Huo, Li Li, Min Li, Shunxin Hu, Changjie Ren, Zongyin Wu, Chenghu Zhang   +8 more
doaj   +1 more source

The impact of remdesivir on renal and liver functions in severe COVID-19 patients with presence of viral load

Scientific Reports
The impact of remdesivir on renal and liver functions remains a matter of concern in advanced COVID-19 patients with high illness severity and presence of viral load.
Petr Waldauf, Ivana Jurisinova, Eva Svobodova, Michaela Diblickova, Tomas Tencer, Jan Zavora, Gabriela Smela, Lenka Kupidlovska, Vaclava Adamkova, Marta Fridrichova, Karolina Jerabkova, Jakub Mikes, Frantisek Duska, Ladislav Dusek, Martin Balik   +14 more
doaj   +1 more source

SARS-CoV-2 Remdesivir Exposure Leads to Different Evolutionary Pathways That Converge in Moderate Levels of Drug Resistance

Viruses
Various SARS-CoV-2 remdesivir resistance-associated substitutions (RAS) have been reported, but a comprehensive comparison of their resistance levels is lacking.
Carlota Fernandez-Antunez, Line A. Ryberg, Kuan Wang, Long V. Pham, Lotte S. Mikkelsen, Ulrik Fahnøe, Katrine T. Hartmann, Henrik E. Jensen, Kenn Holmbeck, Jens Bukh, Santseharay Ramirez   +10 more
doaj   +1 more source

The impact of remdesivir on SARS-CoV-2 evolution in vivo

JCI Insight
The impact of remdesivir on SARS-CoV-2 diversity and evolution in vivo has remained unclear. In this single-center, retrospective cohort study, we assessed SARS-CoV-2 diversification and diversity over time in a cohort of hospitalized patients who did or
Ted Ling-Hu, Lacy M. Simons, Estefany Rios-Guzman, Alexandre Machado Carvalho, Maria Francesca R. Agnes, Arghavan Alisoltanidehkordi, Egon A. Ozer, Ramon Lorenzo-Redondo, Judd F. Hultquist   +8 more
doaj   +1 more source

Real-world effectiveness of early remdesivir in reducing mortality among vulnerable patients hospitalized for COVID-19: Evidence for clinical pharmacists and inpatient care providers. [PDF]

Am J Health Syst Pharm
Loubet P, Chandak A, Spivey S, Doi Y, Amin AN, Ahuja N, Müller V, Sax PE.   +7 more
europepmc   +1 more source

Management of patients hospitalized for SARS-CoV-2 infection: A real-world economic evaluation from the hospital perspective. [PDF]

Am J Health Syst Pharm
Kalil AC, Yaghoubi M, Ahuja N, Kadambi A, Oppelt T, Rivera CG, Kuritzkes DR.   +6 more
europepmc   +1 more source

Lower mortality risk associated with remdesivir plus corticosteroids vs corticosteroids alone for the treatment of patients hospitalized with SARS-CoV-2 infection in the early and later Omicron periods. [PDF]

Am J Health Syst Pharm
Amin AN, Oppelt T, Chandak A, Gottlieb RL, Chima-Melton C, Pettit NN, Kalil AC.   +6 more
europepmc   +1 more source

Real-world effectiveness of remdesivir in immunocompromised patients hospitalized due to SARS-CoV-2 Infection: Insights to inform pharmacy practice. [PDF]

Am J Health Syst Pharm
Kalil AC, Chima-Melton C, Naslazi E, Ramroth H, Amin AN, Pettit NN, Gottlieb RL.   +6 more
europepmc   +1 more source

Treatment of patients hospitalized for COVID-19 with remdesivir is associated with lower likelihood of 30-day readmission: a retrospective observational study

Journal of Comparative Effectiveness Research
Aim: This observational study investigated the association between remdesivir treatment during hospitalization for COVID-19 and 30-day COVID-19-related and all-cause readmission across different variants time periods.
Essy Mozaffari, Aastha Chandak, Robert L Gottlieb, Chidinma Chima-Melton, Andre C Kalil, Vishnudas Sarda, Celine Der-Torossian, Thomas Oppelt, Mark Berry, Alpesh N Amin   +9 more
doaj   +1 more source

Anti-COVID-19 activity and simple HPLC method for concurrent detection of repurposed drugs in novel binary mixtures. [PDF]

AMB Express
Abd Elsalam MA, Kutkat O, Moatasim Y, Mostafa A, Gaballah M, Elgendy AE, Ali MA, Hadad G, Shabayek S.   +8 more
europepmc   +1 more source