Results 31 to 40 of about 362,045 (252)

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

C_max and AUC of triglyceride and blood remnant-like particle cholesterol.

, 2018
Cmax and AUC of triglyceride and blood remnant-like particle cholesterol.
Tsuyoshi Sadakiyo (5159357), Shigeharu Fukuda (336238), Shimpei Ushio (4521769), Yoshifumi Taniguchi (5159348), Hitoshi Mitsuzumi (5159363), Hikaru Watanabe (5159354), Yuki Ishida (5159360), Takeo Sakurai (807214), Ryodai Takagaki (5159351)   +8 more
core   +1 more source

The microbiome in human skin aging

FEBS Letters, EarlyView.
Age‐related skin changes encompass the well‐known visible phenotypic alterations, together with microbiome dysbiosis and a series of molecular aging hallmarks. These hallmarks characterize not only a fully stablished aged phenotype but also the skin aging process itself.
Manuel Huerta Arana, Cornelia Wiegand, Omid Omrani, Mario Fabri   +3 more
wiley   +1 more source

Remnant cholesterol, stronger than triglycerides, is associated with incident non-alcoholic fatty liver disease

Frontiers in Endocrinology, 2023
IntroductionNon-alcoholic fatty liver disease (NAFLD) is characterized by excess accumulation of triglycerides within the liver. However, whether the circulating levels of triglycerides and cholesterol transported in triglyceride-rich lipoproteins ...
Yiping Cheng, Yiping Cheng, Qiang Zhang, Haizhen Li, Guangshuai Zhou, Ping Shi, Ping Shi, Xu Zhang, Xu Zhang, Liying Guan, Fang Yan, Chao Xu, Chao Xu   +12 more
doaj   +1 more source

Partial depletion of plasminogen activator inhibitor‐1 decreases subcutaneous fat cell hypertrophy and liver cholesterol in high‐fat‐fed female mice

FEBS Letters, EarlyView.
Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante, Robert Sharp, Pradip K. Saha, Elizabeth S. Anaya, Elizabeth L. Lieu, Evelyn L. de Groot, Pooja Patel, Mi Jeong Heo, Aaron R. Cox, Kang Ho Kim, Sean M. Hartig   +10 more
wiley   +1 more source

Association between remnant cholesterol and isolated diastolic hypertension in young adults: a cross-sectional study in China

BMC Cardiovascular Disorders
Background Remnant cholesterol, the cholesterol content of triglyceride-rich lipoproteins, has emerged as a novel cardiovascular risk factor. However, its relationship with isolated diastolic hypertension, particularly among young adults, remains unclear.
Ri Liu, Jianhao Su, Chen Qiu
doaj   +1 more source

Elevated remnant cholesterol and non-HDL cholesterol concentrations from real-world laboratory results: a cross-sectional study in Southeast Asians

Frontiers in Cardiovascular Medicine
IntroductionTriglyceride-rich remnant lipoproteins (TRLs) are considered atherogenic due to the presence of remnant cholesterol, which is transported by apolipoprotein B.
Wann Jia Loh, Wann Jia Loh, Heng Samuel Soh, Mon Hnin Tun, Pei Ting Tan, Chin Shern Lau, Subramaniam Tavintharan, Gerald F. Watts, Gerald F. Watts, Tar Choon Aw, Tar Choon Aw   +10 more
doaj   +1 more source

Impact of Remnant Cholesterol on the Risk for End-Stage Renal Disease in Type 2 Diabetes Mellitus: A Nationwide Population-Based Cohort Study [PDF]

Diabetes & Metabolism Journal
Background Remnant cholesterol (remnant-C) has been linked to the risk of various vascular diseases, but the association between remnant-C and end-stage renal disease (ESRD) in patients with type 2 diabetes mellitus (T2DM) remains unclear.
Eun Roh, Ji Hye Heo, Han Na Jung, Kyung-Do Han, Jun Goo Kang, Seong Jin Lee, Sung-Hee Ihm   +6 more
doaj   +1 more source

Small Dense Low‐Density Lipoprotein Cholesterol Is the Most Atherogenic Lipoprotein Parameter in the Prospective Framingham Offspring Study

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2021
Background Elevated plasma levels of direct low‐density lipoprotein cholesterol (LDL‐C), small dense LDL‐C (sdLDL‐C), low‐density lipoprotein (LDL) triglycerides, triglycerides, triglyceride‐rich lipoprotein cholesterol, remnant lipoprotein particle ...
Hiroaki Ikezaki, Elise Lim, L. Adrienne Cupples, Ching‐Ti Liu, Bela F. Asztalos, Ernst J. Schaefer   +5 more
doaj   +1 more source

The heterodimeric amino acid transporters (HAT) of the SLC7/SLC3 family: A structure−function relationships and relevance to human pathology

FEBS Letters, EarlyView.
Heterodimeric amino acid transporters consist of SLC7 and SLC3 family proteins arranged in a conserved structural organization. They regulate nutrient transport across cell membranes, supporting essential cellular functions. These transporters also contribute to xenobiotic/drug uptake and distribution.
Mariafrancesca Scalise, Tiziano Mazza, Raffaella Scanga, Lara Console, Michele Galluccio, Cesare Indiveri   +5 more
wiley   +1 more source