Results 51 to 60 of about 362,045 (252)

Genetics of remnant cholesterol

Purpose of review Remnant cholesterol is receiving increasing attention as a target to reduce residual atherosclerotic cardiovascular disease (ASCVD) risk in individuals already treated with statins. New therapeutic options as antisense oligonucleotides,
Wulff, Anders B., Nordestgaard, Børge G.   +1 more
core   +1 more source

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source

Association of remnant cholesterol with new-onset hypertension among middle-aged and older adults in China

Scientific Reports
Although remnant cholesterol has been associated with cardiovascular disease, the risk of remnant cholesterol and blood pressure remains unclear. This study aimed to investigate the association between remnant cholesterol and new-onset hypertension.
Linghui Cui, Chang Liu, Luzong Yang, Jing Liang, Hao Wang, Chenyang Liu, Fan Zhang, Min Cao   +7 more
doaj   +1 more source

EFFECTS OF DIETARY-CHOLESTEROL ON BILE FORMATION AND HEPATIC PROCESSING OF CHYLOMICRON REMNANT CHOLESTEROL IN THE RAT

, 1993
We have studied the coupling between hepatic uptake of chylomicron remnant cholesteryl ester and biliary excretion of cholesterol and bile acids in rats, after feeding them a cholesterol-free (control) or a high-cholesterol diet (1% wt/wt) for 2 wk.
SMIT, MJ, Kuipers, F; id_orcid, Smit, Martin J., JACKLE, S, WINDLER, EET, Jäckle, Stefan, KUIPERS, F, TEMMERMAN, AM, VONK, RJ   +8 more
core   +1 more source

Extracellular vesicle lipidomics liquid biopsy reveals systemic and tumor microenvironment metabolic reprogramming in ovarian cancer

Molecular Oncology, EarlyView.
Extracellular vesicle (EV) lipidomic profiling of plasma and ascites from patients with high‐grade serous ovarian cancer and of ovarian cancer cell lines reveals enrichment of triglycerides (TGs), diacylglycerols (DGs), phosphatidylcholine (PCs), sphingomyelins (SMs), reflecting tumor metabolic reprogramming.
Shikha Rani, Dominic Guanzon, Andrew Lai, Katherin Scholz‐Romero, Sarah Reed, Edita Ritmejeryte, Rohan Lourie, Naven Chetty, Kaltin Ferguson, Carlos Salomon   +9 more
wiley   +1 more source

Impact of Remnant Cholesterol on Cardiovascular Risk in Diabetes

Purpose of Review: Individuals with diabetes face increased risk of atherosclerotic cardiovascular disease (ASCVD), in part due to hyperlipidemia. Even after LDL cholesterol-lowering, residual ASCVD risk persists, part of which may be attributed to ...
Nordestgaard, Børge Grønne, Wadström, Benjamin Nilsson, Vedel-Krogh, Signe, Elías-López, Daniel, Kobylecki, Camilla Jannie   +4 more
core   +1 more source

The Effect of Proprotein Convertase Subtilisin/Kexin Type 9 Inhibitors on Nonfasting Remnant Cholesterol in a Real World Population [PDF]

, 2018
Background. Proprotein convertase subtilisin/kexin type 9 (PCSK9) inhibitors have demonstrated significant effects on low-density lipoprotein (LDL) cholesterol and nonhigh density lipoprotein (HDL) cholesterol. To date, there have been limited reports on
Holmes, Sari D, Tacker, Danyel H, Morise, Anthony P, Tennant, Jennifer   +3 more
core  

Remnant Cholesterol Elicits Arterial Wall Inflammation and a Multilevel Cellular Immune Response in Humans

, 2017
Mendelian randomization studies revealed a causal role for remnant cholesterol in cardiovascular disease. Remnant particles accumulate in the arterial wall, potentially propagating local and systemic inflammation.
Simone L. Verweij, Hein J. Verberne, Bernelot Moens, Sophie J, Verberne, Hein J., Sophie J. Bernelot Moens, Stroes, Erik S G, Siroon Bekkering, Stroes, Erik S. G., Verweij, Simone L., Verberne, Hein J, Langsted, Anne, Schnitzler, Johan G., Erik S.G. Stroes, Kroon, Jeffrey, Jeffrey Kroon, Børge G. Nordestgaard, Bernelot Moens, Sophie J., Kuijk, Carlijn, Lotte C.A. Stiekema, Voermans, Carlijn, Schnitzler, Johan G, Carlijn Kuijk, Johan G. Schnitzler, Nordestgaard, Børge G., Stiekema, Lotte C. A., Stiekema, Lotte C A, Merijn Bos, Bekkering, Siroon, Nordestgaard, Børge G, Anne Langsted, Verweij, Simone L, Carlijn Voermans, Bos, Merijn   +32 more
core   +1 more source

Additional file 2 of Longitudinal association of remnant cholesterol with joint arteriosclerosis and atherosclerosis progression beyond LDL cholesterol

, 2023
Additional file 2: Fig. S1. Proportions of concordance/discordance among individuals according to LDL-C clinical cutpoints. Fig. S2. Progression trajectories of separate baPWV and ABI. Fig. S3.
Zhiyuan Wu (114653), Zhiwei Li (131853), Xinlei Miao (11086052), Haiping Zhang (2644903), Xiuhua Guo (311454), Jinqi Wang (11086049), Ze Han (1484506), Wei Wang (17594), Yue Liu (292931), Xiaoping Kang (149234), Huiying Pan (11645463), Xia Li (14984), Lixin Tao (519670)   +12 more
core   +1 more source

MagmaFlow: A desktop platform for artificial intelligence‐driven expression analysis

FEBS Open Bio, EarlyView.
MagmaFlow is a free, no‐code platform for gene expression analysis. It generates interactive volcano plots, links genes to literature, pathways, and diseases, prioritizes candidates using millions of publications, identifies affected biological processes, builds network diagrams, and exports publication‐ready figures and reports for macOS and Windows ...
Carlos E. Buss, Ao Li, Eduardo H. Gilglioni, Mayank Bansal, Sumeet Pal Singh, Latifa Bakiri, Alessandra K. Cardozo, Esteban N. Gurzov   +7 more
wiley   +1 more source