Results 51 to 60 of about 20,723 (302)

Exploring the Causal Roles of Circulating Remnant Lipid Profile on Cardiovascular and Cerebrovascular Diseases: Mendelian Randomization Study

Journal of Epidemiology, 2022
Background: Causal evidence of circulating lipids especially the remnant cholesterol with cardiovascular and cerebrovascular disease (CVD) is lacking. This research aimed to explore the causal roles of extensive lipid traits especially the remnant lipids
Shucheng Si, Lei Hou, Xiaolu Chen, Wenchao Li, Xinhui Liu, Congcong Liu, Yunxia Li, Tonghui Yuan, Jiqing Li, Bojie Wang, Hongkai Li, Fuzhong Xue   +11 more
doaj   +1 more source

Apolipoprotein E delivery by peritoneal implantation of encapsulated recombinant cells improves the hyperlipidaemic profile in apoE-deficient mice [PDF]

, 2005
Plasma apolipoprotein E (apoE) is a 34-kDa polymorphic protein which has atheroprotective actions by clearing remnant lipoproteins and sequestering excess cellular cholesterol.
Diakonov, IA, Dickson, G, Graham, IR, Harris, JD, Heald, KA, Mulcahy, JV, Owen, JS, Tagalakis, AD   +7 more
core  

Infrared laser sampling of low volumes combined with shotgun lipidomics reveals lipid markers in palatine tonsil carcinoma

Molecular Oncology, EarlyView.
Nanosecond infrared laser (NIRL) low‐volume sampling combined with shotgun lipidomics uncovers distinct lipidome alterations in oropharyngeal squamous cell carcinoma (OPSCC) of the palatine tonsil. Several lipid species consistently differentiate tumor from healthy tissue, highlighting their potential as diagnostic markers.
Leonard Kerkhoff, Manuela Moritz, Dennis Eggert, Anna Worthmann, Joerg Heeren, Henrike Zech, Till S. Clauditz, Waldemar Wilczak, Hartmut Schlüter, Christian S. Betz, Arne Böttcher, Jan Hahn   +11 more
wiley   +1 more source

Colorectal cancer‐derived FGF19 is a metabolically active serum biomarker that exerts enteroendocrine effects on mouse liver

Molecular Oncology, EarlyView.
Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley, Michael W. Rohr, Joseph A. Goode, Sai Preethi Nakkina, Jignesh G. Parikh, Deborah A. Altomare   +5 more
wiley   +1 more source

Remnant cholesterol, a potential risk factor of metabolic dysfunction-associated fatty liver disease

Nutrition & Metabolism
Objectives This study aimed to explore the association between remnant cholesterol and metabolic dysfunction-associated fatty liver disease (MAFLD) in an adult population in the United States.
Xuanyu Hao, Dongyang Li, Xingyong Huang, Tingting Wang, Peng Wu, Lufan Shen, Kai Zhang, Siyu Sun   +7 more
doaj   +1 more source

Maternal lipid profile in pregnancy and embryonic size: a population-based prospective cohort study

BMC Pregnancy and Childbirth, 2022
Background Lipids are crucial for fetal growth and development. Maternal lipid concentrations are associated with fetal growth in the second and third trimester of pregnancy and with birth outcomes. However, it is unknown if this association starts early
Dionne V. Gootjes, Anke G. Posthumus, Deveney F. Wols, Yolanda B. de Rijke, Jeanine E. Roeters Van Lennep, Eric A. P. Steegers   +5 more
doaj   +1 more source

Remnant cholesterol and atherosclerotic cardiovascular disease: Metabolism, mechanism, evidence, and treatment

Frontiers in Cardiovascular Medicine, 2022
This review aimed to summarize the evidence of elevated remnant cholesterol and the risks of atherosclerotic cardiovascular disease (ASCVD) and to search for further guidance in clinical therapy.
Kexin Wang, Rui Wang, Jiaxin Yang, Xiaoli Liu, Hua Shen, Yan Sun, Yujie Zhou, Zhe Fang, Zhe Fang, Hailong Ge   +9 more
doaj   +1 more source

Delivery of human apolipoprotein (apo) E to liver by an [E1(-), E3(-), polymerase(-), pTP(-)] adenovirus vector containing a liver-specific promoter inhibits atherogenesis in immunocompetent apoE-deficient mice [PDF]

, 2006
Recombinant adenovirus (rAd)-mediated apoE gene transfer to the liver of apoE(-/-) mice is anti-atherogenic. However, first generation rAd vectors were associated with immune clearance of transduced hepatocytes, while an improved [E1(-), E3(-) polymerase(
Amalfitano, A, Dickson, G, Graham, IR, Harris, JD, Owen, JS   +4 more
core  

Lipid levels are inversely associated with infectious and all-cause mortality: international MONDO study results. [PDF]

, 2018
Cardiovascular (CV) events are increased 36-fold in patients with end-stage renal disease. However, randomized controlled trials to lower LDL cholesterol (LDL-C) and serum total cholesterol (TC) have not shown significant mortality improvements.
Canaud, Bernard, Kaysen, George A, Kooman, Jeroen P, Kotanko, Peter, Monitoring Dialysis Outcomes (MONDO) Initiative, Raimann, Jochen G, Stuard, Stefano, Topping, Alice, Usvyat, Len A, van der Sande, Frank M, Wang, Yuedong, Ye, Xiaoling   +11 more
core   +3 more sources

The role of remnant cholesterol beyond low-density lipoprotein cholesterol in diabetes mellitus

Cardiovascular Diabetology, 2022
AbstractBackgroundPrevious research has linked elevated low-density lipoprotein cholesterol (LDL-C) and remnant cholesterol (RC) with diabetes mellitus (DM). The present study aims to estimate the RC-related DM risk beyond LDL-C, and to investigate the extent to which the association of RC and DM is mediated via insulin resistance and inflammation ...
Xiangming Hu, Qunzhi Liu, Xingyuan Guo, Weimian Wang, Bingyan Yu, Beijia Liang, Yingling Zhou, Haojian Dong, Jijin Lin   +8 more
openaire   +3 more sources