Results 61 to 70 of about 20,963 (287)

Remnant cholesterol and atherosclerotic cardiovascular disease: Metabolism, mechanism, evidence, and treatment

Frontiers in Cardiovascular Medicine, 2022
This review aimed to summarize the evidence of elevated remnant cholesterol and the risks of atherosclerotic cardiovascular disease (ASCVD) and to search for further guidance in clinical therapy.
Kexin Wang, Rui Wang, Jiaxin Yang, Xiaoli Liu, Hua Shen, Yan Sun, Yujie Zhou, Zhe Fang, Zhe Fang, Hailong Ge   +9 more
doaj   +1 more source

Familial hypercholesterolemia: The Italian Atherosclerosis Society Network (LIPIGEN) [PDF]

, 2017
Primary dyslipidemias are a heterogeneous group of disorders characterized by abnormal levels of circulating lipoproteins. Among them, familial hypercholesterolemia is the most common lipid disorder that predisposes for premature cardiovascular disease ...
Angelico, F., Arca, M, Averna, M., Bertolini, S, Calandra, S, Casula, M, Catapano, Al, Cefalù, Ab, Del Ben, M., Lipigen, Group, Maranghi, M, Montali, A., Noto, D, Tarugi, P.   +13 more
core   +1 more source

The role of remnant cholesterol beyond low-density lipoprotein cholesterol in diabetes mellitus

Cardiovascular Diabetology, 2022
AbstractBackgroundPrevious research has linked elevated low-density lipoprotein cholesterol (LDL-C) and remnant cholesterol (RC) with diabetes mellitus (DM). The present study aims to estimate the RC-related DM risk beyond LDL-C, and to investigate the extent to which the association of RC and DM is mediated via insulin resistance and inflammation ...
Xiangming Hu, Qunzhi Liu, Xingyuan Guo, Weimian Wang, Bingyan Yu, Beijia Liang, Yingling Zhou, Haojian Dong, Jijin Lin   +8 more
openaire   +3 more sources

Redox regulation meets metabolism: targeting PRDX2 to prevent hepatocellular carcinoma

Molecular Oncology, EarlyView.
PRDX2 acts as a central redox hub linking metabolic dysfunction‐associated steatohepatitis (MASH) to hepatocellular carcinoma (HCC). In normal hepatocytes, PRDX2 maintains redox balance and metabolic homeostasis under oxidative stress. In contrast, during malignant transformation, PRDX2 promotes oncogenic signaling, stemness, and tumor initiation ...
Naroa Goikoetxea‐Usandizaga, María Luz Martinez‐Chantar, Carolina Conter   +2 more
wiley   +1 more source

Remnant Cholesterol: From Pathophysiology to Clinical Implications in Type 1 Diabetes

Endocrines
Remnant cholesterol, contained within triglyceride-rich lipoproteins such as VLDL and IDL, has emerged as an independent risk factor for atherosclerotic cardiovascular disease (ASCVD) in both the general population and individuals with diabetes.
Fernando Sebastian-Valles, Álvaro Montes Muñiz, Mónica Marazuela   +2 more
doaj   +1 more source

ApoE gene therapy: an overview and update [PDF]

, 2005
Atherosclerosis remains the leading cause of death in industrialized societies. Apolipoprotein E (ApoE) is an attractive candidate to treat hypercholesterolemia and coronary heart disease, as it is a circulating protein with pleiotropic ...
Owen, J.S.
core  

Colorectal cancer‐derived FGF19 is a metabolically active serum biomarker that exerts enteroendocrine effects on mouse liver

Molecular Oncology, EarlyView.
Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley, Michael W. Rohr, Joseph A. Goode, Sai Preethi Nakkina, Jignesh G. Parikh, Deborah A. Altomare   +5 more
wiley   +1 more source

Longitudinal association of remnant cholesterol with joint arteriosclerosis and atherosclerosis progression beyond LDL cholesterol

BMC Medicine, 2023
Abstract Background Arteriosclerosis and atherosclerosis are closely related with cardiovascular disease (CVD) risk. Remnant cholesterol (RC) could predict CVD. However, its effect on joint arteriosclerosis and atherosclerosis progression remains unclear.
Wu, Zhiyuan, Wang, Jinqi, Zhang, Haiping, Pan, Huiying, Li, Zhiwei, Liu, Yue, Miao, Xinlei, Han, Ze, Kang, Xiaoping, Li, Xia, Guo, Xiuhua, Tao, Lixin, Wang, Wei   +12 more
openaire   +4 more sources

The role of lipid metabolism in neuronal senescence

FEBS Open Bio, EarlyView.
Disrupted lipid metabolism, through alterations in lipid species or lipid droplet accumulation, can drive neuronal senescence. However, lipid dyshomeostasis can also occur alongside neuronal senescence, further amplifying tissue damage. Delineating how lipid‐induced senescence emerges in neurons and glial cells, and how it contributes to ageing and ...
Dikaia Tsagkari, Eleftheria Panagiotidou, Nektarios Tavernarakis   +2 more
wiley   +1 more source

Association of remnant cholesterol with new-onset hypertension among middle-aged and older adults in China

Scientific Reports
Although remnant cholesterol has been associated with cardiovascular disease, the risk of remnant cholesterol and blood pressure remains unclear. This study aimed to investigate the association between remnant cholesterol and new-onset hypertension.
Linghui Cui, Chang Liu, Luzong Yang, Jing Liang, Hao Wang, Chenyang Liu, Fan Zhang, Min Cao   +7 more
doaj   +1 more source