Results 111 to 120 of about 855,004 (311)

Plasmin Inhibitors Prevent Leukocyte Accumulation and Remodeling Events in the Postischemic Microvasculature [PDF]

, 2011
Clinical trials revealed beneficial effects of the broad-spectrum serine protease inhibitor aprotinin on the prevention of ischemia-reperfusion (I/R) injury. The underlying mechanisms remained largely unclear.
Nina Berberich, Rehberg, Markus, Wymann, Matthias P., Wymann, M. P., Uhl, B., Lerchenberger, Max, Uhl, Bernd, Berberich, Nina, Reichel, Christoph A., Bernd Uhl, Markus Rehberg, Matthias P. Wymann, Zahler, Stefan, Reichel, C. A., Uhl Bernd, Berberich Nina, Krombach Fritz, Lerchenberger, M., Stefan Zahler, Reichel Christoph A., Berberich, N., Fritz Krombach, Rehberg Markus, Zahler, S., Christoph A. Reichel, Krombach, Fritz, Max Lerchenberger, Krombach, F., Lerchenberger Max, Zahler Stefan, Matthias P Wymann, Rehberg, M., Christoph A Reichel, Wymann Matthias P.   +33 more
core   +1 more source

Real‐World Observations in Patients With Obstructive Hypertrophic Cardiomyopathy Treated With Mavacamten: Evidence of Favorable Disease Modification

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease
Background Mavacamten is commercially approved for use in symptomatic patients with obstructive hypertrophic cardiomyopathy. This study evaluated its real‐world impact on symptoms, echocardiographic changes, and the need for septal reduction therapy in ...
Milind Y. Desai, Andrew Gaballa, Yuichiro Okushi, Mohammed Abusafia, Shada Jadam, Katy Rutkowski, Susan Ospina, Sanaa Sultana, Maran Thamilarasan, Craig Asher, Zoran B. Popovic, Bo Xu   +11 more
doaj   +1 more source

Temporal and morphological impact of pressure overload in R403Q mutant mice

Frontiers in Physiology, 2013
Although familial hypertrophic cardiomyopathy (FHC) is characterized as cardiac disease in the absence of overt stressors, disease penetrance and pathological progression largely depend on modifying factors.
Hao eChen, Hyosook eHwang, Laurel A.K. McKee, Jessica N Perez, Jessica A Regan, Eleni eConstantopoulos, Bonnie eLaFleur, John Peter Konhilas   +7 more
doaj   +1 more source

MITF maintains genome stability in nonmelanocyte lineages

Molecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir, Adrián López García de Lomana, Thejus B. Venkatesh, Kritika Kirty, Snaevar Sigurdsson, Linda Vidarsdottir, Ramile Dilshat, Erla Sveinbjornsdottir, Snaedis Ragnarsdottir, Daniel H Magnusson, Maria R. Bustos, Eirikur Steingrimsson, Thorkell Gudjonsson, Stefan Sigurdsson   +13 more
wiley   +1 more source

Obese subjects show sex-specific differences in right ventricular hypertrophy [PDF]

, 2014
As right ventricular (RV) remodeling in obesity remains underinvestigated, and the impact of left ventricular (LV) diastolic dysfunction on RV hypertrophy is unknown, we aimed to investigate whether (1) sex-specific patterns of RV remodeling exist in ...
Francis, JM, Rider, OJ, Lewandowski, AJ, Nethononda, R, Petersen, SE, Lewis, AJ, Neubauer, Stefan, Rider, Oliver, Ntusi, N, Leeson, Christopher, Lewi, AJM, Pitcher, A, Neubauer, S, Banerjee, R, Leeson, P   +14 more
core   +1 more source

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

Molecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim, Hwiyeong Lee, Jin Hong, Daechan Park   +3 more
wiley   +1 more source

Vascular Repair and Remodeling: A Review [PDF]

, 2017
Cardiovascular diseases (CVDs) such as ischemic heart disease (IHD), stroke, and peripheral artery disease (PAS) are the leading cause of mortality and morbidity around the world: about 30% of global deaths and 10% of global disease burden a year are due
Rodrigo Garcia, Jesica Ramirez, Ramírez, Jésica, Nicolas F. Renna, Roberto M. Miatello, Miatello, Roberto Miguel, García, Rodrigo Damián, Renna, Nicolas Federico   +7 more
core   +1 more source

Persistence of high density lipoprotein particles in obese mice lacking apolipoprotein A-I

Journal of Lipid Research, 2005
Obese mice without leptin (ob/ob) or the leptin receptor (db/db) have increased plasma HDL levels and accumulate a unique lipoprotein referred to as LDL/HDL1.
Marnie L. Gruen, Michelle R. Plummer, Wenwu Zhang, Kelly A. Posey, MacRae Linton, Sergio Fazio, Alyssa H. Hasty   +6 more
doaj   +1 more source

Sex and ventricular remodeling

Current Opinion in Physiology
The composite of changes sustained by the left ventricle during pathologic and physiologic stimuli is known as ventricular remodeling. These changes involve alterations to individual cells, the surrounding matrix, and overall ventricular structure and function.
Steven P Jones, Helen E Collins
openaire   +2 more sources

Spatial and single‐nuclei transcriptomics reveals idiosyncratic and generic patterns in papillary and anaplastic thyroid cancers

Molecular Oncology, EarlyView.
Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur, Joel Rodrigues Vitória, Manuel Saiselet, Ligia Craciun, Denis Larsimont, Anne Lefort, Frédérick Libert, Carine Maenhaut, Sabine Costagliola, Maxime Tarabichi, Mirian Romitti, Vincent Detours   +11 more
wiley   +1 more source