Results 91 to 100 of about 855,004 (311)
SWI/SNF Complex Prevents Lineage Reversion and Induces Temporal Patterning in Neural Stem Cells [PDF]
, 2014 Members of the SWI/SNF chromatin-remodeling complex are among the most frequently mutated genes in human cancer, but how they suppress tumorigenesis is currently unclear.
Knoblich, Juergen A. +7 more
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A Survey of Retinal Remodeling [PDF]
Frontiers in Cellular Neuroscience, 2015 Up to 15 years ago, bibliographic searches based on keywords such as "photoreceptor degeneration, inner retina" or "photoreceptor degeneration, second order neurons" returned only a handful of papers, as the field was dominated by the general assumption that retinal degeneration had direct effects on the sole populations of rods and cones.
openaire +4 more sources
FEBS Letters, EarlyView.Mycobacterial 3‐methylcrotonyl‐CoA carboxylase uses a mobile biotin‐carrying domain to shuttle a carboxyl group between two catalytic sites, enabling carboxylation of 3‐methylcrotonyl‐CoA during leucine breakdown. Cryo‐electron microscopy captures the carrier at both sites and reveals an inward loop movement that may prevent futile rebinding to the ...
Ajit Yadav +2 more
wiley +1 more source
SMARCB1 orchestrates cellular plasticity and oncogenic pathways in typical and chondroid chordomas
Scientific ReportsChordomas are rare, aggressive tumors of the axial skeleton with limited treatment options. Genetic alterations in SMARCB1, a tumor suppressor gene, have been implicated in poorly differentiated chordomas, but their role in typical and chondroid subtypes
Weihai Liu +7 more
doaj +1 more source
Modalities for visualization of cortical bone remodeling: the past, present and near future
Frontiers in Endocrinology, 2015 Bone’s ability to respond to load-related phenomena and repair microdamage is achieved through the remodeling process which renews bone by activating groups of cells known as Basic Multicellular Units (BMUs). The products of BMUs, secondary osteons, have
Kimberly Dawn Harrison +1 more
doaj +1 more source
Chemokines and Bone Remodeling
International Journal of Immunopathology and Pharmacology, 2008 Bone remodeling is characterized by spatial and temporal coupling of bone resorption and formation and is necessary for skeletal growth and normal bone structure maintenance. Imbalance of this process is related to metabolic bone disorders such as osteoporosis or rheumatoid arthritis.
E. Galliera +3 more
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FEBS Letters, EarlyView.How do genomes gain new functional parts? In eukaryotes, which tend to evolve under weak selection, much of the genome is junk. Palazzo and Qiu borrow the logic of Markov chains to show how non‐functional DNA becomes functional through the appearance of intermediate states, which arise due to epistasis, buffering, and biochemical messiness, allowing ...
Alexander F. Palazzo, Yi Qiu
wiley +1 more source
Mechanism of Airway Remodeling Induced by Repeated Inhalation of Methacholine in a Mouse Model of Asthma [PDF]
, 2015 Background:Increased severity of asthma is contributed by airway tissue remodeling, which may be associated with chronic allergic inflammation. A recent study revealed the potential capacity of repeated bronchoconstriction, e.g.
Fueki, Naoto +6 more
core
Changes in left ventricular systolic function in patients with chronic heart failure with preserved ejection fraction and cardiorenal anemic syndrome [PDF]
Medičnì Perspektivi, 2015 The feature of chronic heart failure (CHF) in elderly people is increasing incidence of heart failure with preserved left ventricular ejection fraction (LVEF) which is associated with age.
Vasylenko V.A.
doaj
The ubiquitin system in normal and infected germinal center B cells
FEBS Letters, EarlyView.The ubiquitin system plays a central role in germinal center (GC) B cells, influencing differentiation to long‐lived memory B cells. Oncogenic gammaherpesviruses gain access to memory B cells by establishing latency in GC B cells. Mapping ubiquitin mechanisms in normal and infected GC B cells will define specific molecular circuits in B cells germane ...
Destiny Davis +2 more
wiley +1 more source