Results 81 to 90 of about 855,004 (311)

The microbiome in human skin aging

FEBS Letters, EarlyView.
Age‐related skin changes encompass the well‐known visible phenotypic alterations, together with microbiome dysbiosis and a series of molecular aging hallmarks. These hallmarks characterize not only a fully stablished aged phenotype but also the skin aging process itself.
Manuel Huerta Arana, Cornelia Wiegand, Omid Omrani, Mario Fabri   +3 more
wiley   +1 more source

Regulation of NSL by TAF4A is critical for genome stability and quiescence of muscle stem cells

Nature Communications
Acetylation of lamin A/C by the non-specific lethal complex, containing MOF and KANSL2, is instrumental for maintaining nuclear architecture and genome stability, but the mechanisms controlling expression of its components in different cell types are ...
Angelina M. Georgieva, Krishna Sreenivasan, Dong Ding, Clementine Villeneuve, Sara A. Wickström, Stefan Günther, Carsten Kuenne, Ulrich Gärtner, Xinyue Guo, Yonggang Zhou, Xuejun Yuan, Thomas Braun   +11 more
doaj   +1 more source

Partial depletion of plasminogen activator inhibitor‐1 decreases subcutaneous fat cell hypertrophy and liver cholesterol in high‐fat‐fed female mice

FEBS Letters, EarlyView.
Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante, Robert Sharp, Pradip K. Saha, Elizabeth S. Anaya, Elizabeth L. Lieu, Evelyn L. de Groot, Pooja Patel, Mi Jeong Heo, Aaron R. Cox, Kang Ho Kim, Sean M. Hartig   +10 more
wiley   +1 more source

Airway Remodeling in a Guinea Pig Model of Chronic Asthma : Its Influence on Airway Responsiveness and Pharmacological Properties of Airway Smooth Muscle, and Its Prevention by Corticosteroids [PDF]

, 2003
Airway remodeling in bronchial asthma occurs as a result of continuance or repetition of eosinophilic airway inflammation. It has the potential to affect airway responsiveness to nonspecific stimuli and the pharmacological properties of airway smooth ...
Kamikawa, Yuichiro, Hiyama, Takako, Ota, Mayumi, Sagara, Hironori, Nakano, Yasuhiro   +4 more
core  

CIDEC Restricts Liver Regeneration by Disturbing Lipid Droplet Triglyceride Turnover

Advanced Science
The transient accumulation of triglyceride (TG)‐enriched lipid droplets (LDs) in hepatocytes during early liver regeneration is critical for generation but remains mechanistically unclear, particularly the roles of LD fusion‐associated proteins in lipid ...
Feng Ouyang, Yining Li, Zixuan Zhang, Fangfang Sun, Yihong Shi, Qian Gui, Da Luo, Changyong Hu, Hang Su, Kaiqi Shen, Lu Gao, Hui Yang, Feng‐Jung Chen, Rong Li, Tong‐Jin Zhao, Peng Li, Tian‐Shu Yang   +16 more
doaj   +1 more source

RENAL ARTERIES REMODELLING — THE INITIATOR AND TARGET OF CARDIORENAL CONTINUUM

Кардиоваскулярная терапия и профилактика, 2015
Cardiorenal syndrome (CRS) is one of the most important problems in contemporary medicine, due to high values of morbidity and mortality from cardiovascular and renal systems.
T. S. Levitskaya, М. М. Batyushin, D. G. Pasechnik, E. G. Asrumian   +3 more
doaj   +1 more source

Aortic Root Remodeling

Operative Techniques in Thoracic and Cardiovascular Surgery, 2018
Aortic root remodeling was originally designed in the late 1980s to treat patients with tricuspid aortic valves (TAVs), aortic regurgitation (AR), and root aneurysm to normalize root dimensions. The late results showed a relevant proportion of patients who required reoperation for recurrent AR.
Giebels, Christian, Ehrlich, Tristan, Schäfers, Hans-Joachim   +2 more
openaire   +2 more sources

Emerging experimental and computational methods for studying redox‐regulated structural transitions

FEBS Letters, EarlyView.
Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass, Dana Reichmann, Gábor Erdős   +2 more
wiley   +1 more source

Intracellular Angiotensin‐II Interacts With Nuclear Angiotensin Receptors in Cardiac Fibroblasts and Regulates RNA Synthesis, Cell Proliferation, and Collagen Secretion

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2017
BackgroundCardiac fibroblasts play important functional and pathophysiological roles. Intracellular (“intracrine”) angiotensin‐II (Ang‐II) signaling regulates intercellular communication, excitability, and gene expression in cardiomyocytes; however, the ...
Artavazd Tadevosyan, Jiening Xiao, Sirirat Surinkaew, Patrice Naud, Clémence Merlen, Masahide Harada, Xiaoyan Qi, David Chatenet, Alain Fournier, Bruce G. Allen, Stanley Nattel   +10 more
doaj   +1 more source

Synergistic perspectives—How single‐molecule biophysics complement biochemical understanding

FEBS Letters, EarlyView.
In this review, we discuss how ensemble biochemistry and single‐molecule approaches are complementary, outline commonly used single‐molecule techniques, and illustrate their relevance through two representative case studies: chromatin organization by SMC complexes and pathway choice during DNA double‐strand break repair.
Sara De Bragança, Eline L. Jansen, Jorine M. Eeftens   +2 more
wiley   +1 more source