Results 21 to 30 of about 855,004 (311)

Remodeling KRAS [PDF]

Structure, 2017
Mutations in members of the RAS family of small GTPases have been associated with numerous human cancers. However, RAS family members are notoriously difficult to target. In this issue of Structure, Lu et al. (2017) examine the effects of two compounds with distinct chemical scaffolds on the structure and dynamics of an oncogenic KRAS mutant, thus ...
Daniel J, Deredge, Patrick L, Wintrode
openaire   +2 more sources

Concentric left ventricular remodeling and aortic stiffness: a comparison of obesity and hypertension. [PDF]

, 2013
BACKGROUND: Increased thoracic ascending aortic stiffness is thought to contribute to concentric left ventricular hypertrophy and increased mortality, a pattern seen in hypertension.
Francis, JM, Rider, OJ, Nethononda, R, Petersen, SE, Neubauer, Stefan, Francis, Jane M., Rider, Oliver J., Petersen, Steffen E., Neubauer, S, Nethononda, Richard, Clarke, Kieran, Byrne, James, Clarke, K, Byrne, JP, Leeson, P, Leeson, Paul   +15 more
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Bathroom Remodeling Port Arthur TX

, 2021
Bathroom renovations require a ton of scrupulousness. Our experts have been taking care of this sort of work for quite a long time. Leave it to us to ask you the correct inquiries.
Port Arthur Bathroom Remodeling
core   +1 more source

Implication of the p53-Related miR-34c, -125b, and -203 in the Osteoblastic Differentiation and the Malignant Transformation of Bone Sarcomas

Cells, 2020
The formation of the skeleton occurs throughout the lives of vertebrates and is achieved through the balanced activities of two kinds of specialized bone cells: the bone-forming osteoblasts and the bone-resorbing osteoclasts. Impairment in the remodeling
Camille Jacques, Robel Tesfaye, Melanie Lavaud, Steven Georges, Marc Baud’huin, François Lamoureux, Benjamin Ory   +6 more
doaj   +1 more source

Advances of exosomes in periodontitis treatment

Journal of Translational Medicine, 2022
Periodontitis is an inflammatory disease initiated by dysbiosis of the local microbial community. Periodontitis can result in destruction of tooth-supporting tissue; however, overactivation of the host immune response is the main reason for alveolar bone
Hongbing Lin, Huishan Chen, Xuetao Zhao, Tong Ding, Yawei Wang, Zhen Chen, Yue Tian, Peipei Zhang, Yuqin Shen   +8 more
doaj   +1 more source

Uterine spiral artery remodeling involves endothelial apoptosis induced by extravillous trophoblasts through Fas/FasL interactions. [PDF]

, 2005
Objective— Invasion of uterine spiral arteries by extravillous trophoblasts in the first trimester of pregnancy results in loss of endothelial and musculoelastic layers.
Philip R. Dash, Cartwright, JE, Whitley, GS, Ashton, SV, Philip N. Baker, Crocker, IP, Baker, PN, Guy St. J. Whitley, Ian P. Crocker, Mark Wareing, Wareing, M, Sandra V. Ashton, Judith E. Cartwright, Dash, PR   +13 more
core   +1 more source

3D porous architecture of stacks of β-TCP granules compared with that of trabecular bone: a microCT, vector analysis and compression study

Frontiers in Endocrinology, 2015
The 3D arrangement of porous granular biomaterials usable to fill bone defects has received little study. Granular biomaterials occupy 3D space when packed together in a manner that creates a porosity suitable for the invasion of vascular and bone cells.
Daniel eCHAPPARD, Daniel eCHAPPARD, Lisa eTerranova, Romain eMallet, Romain eMallet, Philippe eMercier, Philippe eMercier   +6 more
doaj   +1 more source

Inhibition of Trophoblast-Induced Spiral Artery Remodeling Reduces Placental Perfusion in Rat Pregnancy. [PDF]

, 2010
Rats harboring the human angiotensinogen and human renin genes develop preeclamptic features in pregnancy. The preeclamptic rats exhibit a deeper trophoblast invasion associated with a reduced resistance index by uterine Doppler.
Muller, DN, Cartwright, JE, Pijnenborg, R, Pijnenborg, R., Stefan Verlohren, Luft, F.C., Mueller, D.N., Lydia Hering, Morton, J., Davidge, ST, Dechend, R, Geusens, N, Robert Pijnenborg, Herse, F, Judith E. Cartwright, Herse, F., Florian Herse, Ralf Dechend, Dudenhausen, J.W., Nele Geusens, Cartwright, J.E., Geusens, N., Verhaegen, I., Jude Morton, Morton, J, Hering, L, Iris Verhaegen, Dominik N. Muller, Dechend, R., Sandra T. Davidge, Joachim W. Dudenhausen, Hering, L., Davidge, S.T., Verlohren, S, Verhaegen, I, Dudenhausen, JW, Friedrich C. Luft, Verlohren, S., Luft, FC   +38 more
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Chromatin remodeling enzyme Brg1 is required for mouse lens fiber cell terminal differentiation and its denucleation [PDF]

, 2010
Background: Brahma-related gene 1 (Brg1, also known as Smarca4 and Snf2 beta) encodes an adenosine-5'-triphosphate (ATP)-dependent catalytical subunit of the (switch/sucrose nonfermentable) (SWI/SNF) chromatin remodeling complexes.
He, Shuying, Metzger, Daniel, Wolf Louise, Bharesh K Chauhan, Chambon, Pierre, Ruth Ashery-Padan, Nakai, Akira, Zavadil, Jiri, Cveklova Kveta, Daniel Metzger, Ernst R Tamm, Chauhan Bharesh K, Metzger Daniel, Melinda K Pirity, Wang Wei-Lin, Chauhan, Bharesh K., Pierre Chambon, Cveklova, Kveta, Cvekl Ales, Akira Nakai, Ales Cvekl, Pirity Melinda K, Wolf, Louise, Tamm, Ernst R., Ashery-Padan, Ruth, Cvekl, Ales, Chambon Pierre, Wang, Wei-Lin, Wei-Lin Wang, Ashery-Padan Ruth, Nakai Akira, He Shuying, Shuying He, Kveta Cveklova, Zavadil Jiri, Louise Wolf, Tamm Ernst R, Jiri Zavadil, Pirity, Melinda K.   +38 more
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Apoptotic mesenchymal stromal cells support osteoclastogenesis while inhibiting multinucleated giant cells formation in vitro

Scientific Reports, 2021
In bone regeneration induced by the combination of mesenchymal stromal cells (MSCs) and calcium-phosphate (CaP) materials, osteoclasts emerge as a pivotal cell linking inflammation and bone formation.
Paul Humbert, Meadhbh Á. Brennan, Julien De Lima, Régis Brion, Annie Adrait, Céline Charrier, Bénédicte Brulin, Valérie Trichet, Yohann Couté, Frédéric Blanchard, Pierre Layrolle   +10 more
doaj   +1 more source