Results 61 to 70 of about 4,080,709 (367)

Fabry′s disease

Medical Journal of Dr. D.Y. Patil University, 2015
Fabry′s disease is an X-linked multisystem disorder due to the deficiency of lysosomal enzyme α-galactosidase A, leads to accumulation of sphingolipids throughout the body. Key causes for premature death include cardiac and renal.
Laxmikant Ramkumarsingh Tomar, Ajinkya Ashok Sonambekar, Sambav Gupta, Nikhil Gupta   +3 more
doaj   +1 more source

Biochemical Studies in Perfundates and Homogenates of Isolated Porcine Kidneys after Flushing with Zinc or Zinc–Prolactin Modified Preservation Solution Using a Static Cold Storage Technique

Molecules, 2021
Zinc is an effective anti-inflammatory and antioxidant trace element. The aim of this study was to analyse the protective effect of zinc and zinc–prolactin systems as additives of preservation solutions in the prevention of nephron damage caused during ...
Aneta Ostróżka-Cieślik, Barbara Dolińska, Florian Ryszka   +2 more
doaj   +1 more source

Ligand recognition by 14‐3‐3 proteins requires negative charges but not necessarily phosphorylation

FEBS Letters, Volume 599, Issue 6, Page 838-847, March 2025.
Interactions of 14‐3‐3 proteins with their binding partners are attributed to phosphorylation of the binding partners. In this work, we show that at least one negative charge is required for the peptides to bind 14‐3‐3ε, although phosphorylation is not necessary, and that two negative charges are preferable for high affinity binding.
Seraphine Kamayirese, Laura A. Hansen, Sándor Lovas   +2 more
wiley   +1 more source

Circadian Blood Pressure Rhythm in Cardiovascular and Renal Health and Disease

Biomolecules, 2021
Blood pressure (BP) follows a circadian rhythm, it increases on waking in the morning and decreases during sleeping at night. Disruption of the circadian BP rhythm has been reported to be associated with worsened cardiovascular and renal outcomes ...
Jiayang Zhang, Ruoyu Sun, Tingting Jiang, Guangrui Yang, Lihong Chen   +4 more
doaj   +1 more source

Cardiorespiratory fitness: a comparison between children with renal transplantation and children with congenital solitary functioning kidney [PDF]

, 2016
Children with end-stage renal disease are known to have a cardiorespiratory fitness significantly reduced. This isconsidered to be an independent index predictive of mortality mainly due to cardiovascular accidents. The effectsof renal transplantation on
Elli, Marco, Falsaperla, Raffaele, Lubrano, Riccardo, Tancredi, Giancarlo   +3 more
core   +2 more sources

The Banff 97 working classification of renal allograft pathology.

Kidney International, 1999
BACKGROUND Standardization of renal allograft biopsy interpretation is necessary to guide therapy and to establish an objective end point for clinical trials.
L. Racusen, K. Solez, R. Colvin, S. Bonsib, M. C. Castro, T. Cavallo, B. Croker, A. Demetris, C. Drachenberg, A. Fogo, P. Furness, L. Gaber, I. Gibson, Dennis Glotz, J. Goldberg, Joseph Grande, P. Halloran, H. E. Hansen, B. Hartley, P. Hayry, C. Hill, Ernesto O. Hoffman, L. Hunsicker, A. Lindblad, N. Marcussen, M. Mihatsch, T. Nadasdy, P. Nickerson, T. Olsen, J. Papadimitriou, P. Randhawa, D. Rayner, I. Roberts, S. Rose, D. Rush, L. Salinas‐Madrigal, D. Salomon, S. Sund, E. Taskinen, K. Trpkov, Y. Yamaguchi   +40 more
semanticscholar   +1 more source

Calcium‐sensing receptor‐ and ADAM10‐mediated klotho shedding is regulated by tetraspanin 5

FEBS Letters, Volume 599, Issue 6, Page 866-875, March 2025.
The G protein‐coupled calcium‐sensing receptor (CaSR) and the disintegrin/metalloprotease ADAM10 in the renal distal convoluted tubule control systemic levels of Klotho, a cell and tissue homeostasis‐preserving factor. We show that CaSR‐induced cleavage of membrane‐bound αKlotho by ADAM10 requires tetraspanin 5 (Tspan5), a scaffolding and chaperone ...
Zhenan Liu, Joonho Yoon, Eunyoung Lee, Audrey N. Chang, R. Tyler Miller   +4 more
wiley   +1 more source

Effect of Different Dosage Frequency of Polymyxin B on Rat Nephrotoxicity

Drug Design, Development and Therapy, 2021
Wenrui Sun,1,* Binchuan Hu,2,* Xiaoshan Zhang,1,3 Yuzhen Wang1 1,3 Zheng Xiang,3 Guanyang Lin1 1The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, 325000, People’s Republic of China; 2Yongjia People’s Hospital, Wenzhou ...
Sun W, Hu B, Zhang X, Wang Y, Xiang Z, Lin G   +5 more
doaj  

A rare case of renal thrombotic microangiopathy associated with Castleman’s disease [PDF]

, 2017
BACKGROUND: Castleman’s disease (CD) is an uncommon, heterogeneous lympho-proliferative disorder leading to high circulating levels of interleukin-6 (IL-6) and vascular endothelial growth factor (VEGF).
Chen, Ying Maggie, Cossey, L. Nicholas, Liapis, Helen, Mutneja, Ahubha   +3 more
core   +2 more sources

Insights into the renal pathophysiology in Hermansky‐Pudlak syndrome‐1 from urinary extracellular vesicle proteomics and a new mouse model

FEBS Letters, Volume 599, Issue 7, Page 1055-1074, April 2025.
Hermansky‐Pudlak syndrome type 1 (HPS‐1) is a rare, autosomal recessive disorder with poorly understood renal involvement. Urinary extracellular vesicle (uEV) proteomics and a novel Hps1 mouse model reveal mitochondrial abnormalities and lipid accumulation in HPS‐1 kidney proximal tubule cells. Serum ApoA1 correlates with kidney function in our patient
Dawn M. Maynard, Bernadette R. Gochuico, Hadass Pri Chen, Christopher K. E. Bleck, Patricia M. Zerfas, Wendy J. Introne, William A. Gahl, May C. V. Malicdan   +7 more
wiley   +1 more source