Biological Pathways and Potential Targets for Prevention and Therapy of Chronic Allograft Nephropathy [PDF]
, 2014 Renal transplantation (RT) is the best option for patients with end-stage renal disease, but the half-life is limited to a decade due to progressive deterioration of renal function and transplant failure from chronic allograft nephropathy (CAN), which is
Haylor, John, Shrestha, Badri Man
core +6 more sources
Primary squamous cell carcinoma of the renal parenchyma
Indian Journal of Pathology and Microbiology, 2012 No case of a primary renal parenchymal squamous cell carcinoma (SCC) has been reported previously in the literature although renal pelvic SCCs are well known. We report an unusual case in a 60-year-old lady who presented with significant weight loss. She
P Kulshreshtha +3 more
doaj +1 more source
Multimodal Deep Learning for Personalized Renal Cell Carcinoma Prognosis: Integrating CT Imaging and Clinical Data [PDF]
arXiv, 2023 Renal cell carcinoma represents a significant global health challenge with a low survival rate. This research aimed to devise a comprehensive deep-learning model capable of predicting survival probabilities in patients with renal cell carcinoma by integrating CT imaging and clinical data and addressing the limitations observed in prior studies. The aim
arxiv
Immunoregulatory mechanisms of the arachidonic acid pathway in cancer
FEBS Letters, Volume 599, Issue 7, Page 927-951, April 2025.The central role of the arachidonic acid (AA) pathway in anticancer immunity. Enzymes and metabolites of the AA pathway can play both immunosuppressive and immunostimulatory roles in the tumor microenvironment. Therefore, their tailored targeting could be beneficial as a standalone therapy or in combination with current cancer immunotherapy.
Maria Tredicine +3 more
wiley +1 more source
MUVF-YOLOX: A Multi-modal Ultrasound Video Fusion Network for Renal Tumor Diagnosis [PDF]
arXiv, 2023 Early diagnosis of renal cancer can greatly improve the survival rate of patients. Contrast-enhanced ultrasound (CEUS) is a cost-effective and non-invasive imaging technique and has become more and more frequently used for renal tumor diagnosis. However, the classification of benign and malignant renal tumors can still be very challenging due to the ...
arxiv
Dosing Oncology Therapeutics in Combination Therapy for Renal Dysfunction: The University of California San Diego Study of Personalized Cancer Therapy to Determine Response and Toxicity (UCSD-PREDICT) Experience. [PDF]
, 2018 Introduction Dose reductions are often required to avoid toxicity in combination therapy for advanced cancers, but information on appropriate dose reductions in renal dysfunction is lacking. This study assessed dose reductions of renally cleared oncology
Capparelli, Edmund +3 more
core
Splenectomy and Thymectomy in Human Renal Homotransplantation [PDF]
, 1963 Five patients with terminal renal failure have been treated with renal homografts. Total body irradiation and cytotoxic drugs were used to prevent rejection.
Marchioro, TL +3 more
core +1 more source
Annual Review of Physiology, 2018 Tubulointerstitial fibrosis is a chronic and progressive process affecting kidneys during aging and in chronic kidney disease (CKD), regardless of cause.
B. Humphreys
semanticscholar +1 more source
Ion channel function of polycystin‐2/polycystin‐1 heteromer revealed by structure‐guided mutagenesis
FEBS Letters, EarlyView.Mutations in polycystin‐1 (PC1) or polycystin‐2 (PC2) cause autosomal‐dominant polycystic kidney disease (ADPKD). We generated a novel gain‐of‐function PC2/PC1 heteromeric ion channel by mutating pore‐blocking residues. Moreover, we demonstrated that PC2 will preferentially assemble with PC1 to form heteromeric complexes when PC1 is co‐expressed ...
Tobias Staudner +7 more
wiley +1 more source
International Journal of Hyperthermia, 2023 Histotripsy is an emerging noninvasive, non-thermal, and non-ionizing focused ultrasound (US) therapy that can be used to destroy targeted tissue.
Katrina L. Falk +9 more
doaj +1 more source